1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	G	F	L	G	V	V	P	S	F	L	K	V	L	A	G	M	H	N	E	I	V	G	D	I	K	R	A	T	D	T	V	A	G	I	S	G	R	V	Q	L	T	H	G	S	F	T	S	K	F	N	D	T	L	Q	E	F	E	T
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?										?		?								?	?	?				?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.
Sequence		T	R	S	S	T	G	T	G	L	Q	G	V	T	S	G	L	A	N	N	L	L	A	A	A	G	A	Y	L	K	A	D	D	G	L	A	G	V	I	D	K	I	F	G
Secondary structure
SS confidence
Disorder																																											?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 17%) Alpha helix ( 94%) Beta strand ( 0%)

Rank Aligned region

PDB 1wa8 chain A domain 1 Region: 5 - 103 Aligned: 96 Modelled: 99 Confidence: 97.7% Identity: 15% Fold: Ferritin-like Superfamily: EsxAB dimer-like Family: ESAT-6 like Phyre2 PDB 4iog chain D Region: 1 - 90 Aligned: 86 Modelled: 90 Confidence: 97.4% Identity: 14% PDB header:unknown function Chain: D: PDB Molecule:secreted protein esxb; PDBTitle: the crystal structure of a secreted protein esxb (wild-type, in p212 space group) from bacillus anthracis str. sterne Phyre2 PDB 3gvm chain A Region: 5 - 98 Aligned: 91 Modelled: 94 Confidence: 97.3% Identity: 13% PDB header:viral protein Chain: A: PDB Molecule:putative uncharacterized protein sag1039; PDBTitle: structure of the homodimeric wxg-100 family protein from streptococcus2 agalactiae Phyre2 PDB 3zbh chain C Region: 8 - 98 Aligned: 88 Modelled: 88 Confidence: 96.7% Identity: 14% PDB header:unknown function Chain: C: PDB Molecule:esxa; PDBTitle: geobacillus thermodenitrificans esxa crystal form i Phyre2 PDB 2vs0 chain B Region: 5 - 91 Aligned: 84 Modelled: 87 Confidence: 96.6% Identity: 11% PDB header:cell invasion Chain: B: PDB Molecule:virulence factor esxa; PDBTitle: structural analysis of homodimeric staphylococcal aureus2 virulence factor esxa Phyre2 PDB 4lws chain A Region: 5 - 101 Aligned: 94 Modelled: 97 Confidence: 95.3% Identity: 6% PDB header:unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: esxa : esxb (semet) hetero-dimer from thermomonospora curvata Phyre2 PDB 4lws chain B Region: 1 - 87 Aligned: 84 Modelled: 87 Confidence: 95.2% Identity: 10% PDB header:unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: esxa : esxb (semet) hetero-dimer from thermomonospora curvata Phyre2 PDB 4wj2 chain A Region: 60 - 98 Aligned: 39 Modelled: 39 Confidence: 91.3% Identity: 26% PDB header:unknown function Chain: A: PDB Molecule:antigen mtb48; PDBTitle: mycobacterial protein Phyre2 PDB 1wa8 chain B domain 1 Region: 4 - 96 Aligned: 90 Modelled: 93 Confidence: 90.6% Identity: 13% Fold: Ferritin-like Superfamily: EsxAB dimer-like Family: ESAT-6 like Phyre2 PDB 2kg7 chain B Region: 5 - 95 Aligned: 88 Modelled: 91 Confidence: 77.8% Identity: 14% PDB header:unknown function Chain: B: PDB Molecule:esat-6-like protein esxh; PDBTitle: structure and features of the complex formed by the tuberculosis2 virulence factors rv0287 and rv0288 Phyre2 PDB 4xy3 chain A Region: 60 - 95 Aligned: 36 Modelled: 36 Confidence: 70.7% Identity: 22% PDB header:protein transport Chain: A: PDB Molecule:esx-1 secretion-associated protein espb; PDBTitle: structure of esx-1 secreted protein espb Phyre2 PDB 4i0x chain A Region: 10 - 87 Aligned: 75 Modelled: 75 Confidence: 38.9% Identity: 13% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:esat-6-like protein mab_3112; PDBTitle: crystal structure of the mycobacterum abscessus esxef (mab_3112-2 mab_3113) complex Phyre2 PDB 2kg7 chain A Region: 53 - 96 Aligned: 44 Modelled: 44 Confidence: 23.8% Identity: 23% PDB header:unknown function Chain: A: PDB Molecule:uncharacterized protein esxg (pe family protein); PDBTitle: structure and features of the complex formed by the tuberculosis2 virulence factors rv0287 and rv0288 Phyre2 PDB 3qml chain C Region: 4 - 17 Aligned: 14 Modelled: 14 Confidence: 10.6% Identity: 29% PDB header:chaperone/protein transport Chain: C: PDB Molecule:nucleotide exchange factor sil1; PDBTitle: the structural analysis of sil1-bip complex reveals the mechanism for2 sil1 to function as a novel nucleotide exchange factor Phyre2 PDB 4af3 chain D Region: 97 - 103 Aligned: 7 Modelled: 7 Confidence: 9.3% Identity: 29% PDB header:transferase/inhibitor Chain: D: PDB Molecule:inner centromere protein; PDBTitle: human aurora b kinase in complex with incenp and vx-680 Phyre2 PDB 2vgp chain D Region: 97 - 103 Aligned: 7 Modelled: 7 Confidence: 9.2% Identity: 29% PDB header:transferase Chain: D: PDB Molecule:inner centromere protein a; PDBTitle: crystal structure of aurora b kinase in complex with a2 aminothiazole inhibitor Phyre2 PDB 5jx6 chain C Region: 4 - 41 Aligned: 38 Modelled: 38 Confidence: 8.7% Identity: 11% PDB header:hydrolase Chain: C: PDB Molecule:glucanase; PDBTitle: gh6 orpinomyces sp. y102 enzyme Phyre2 PDB 2c52 chain B domain 1 Region: 78 - 103 Aligned: 26 Modelled: 26 Confidence: 8.6% Identity: 15% Fold: Nuclear receptor coactivator interlocking domain Superfamily: Nuclear receptor coactivator interlocking domain Family: Nuclear receptor coactivator interlocking domain Phyre2 PDB 1kbh chain A Region: 78 - 103 Aligned: 26 Modelled: 26 Confidence: 8.2% Identity: 19% Fold: Nuclear receptor coactivator interlocking domain Superfamily: Nuclear receptor coactivator interlocking domain Family: Nuclear receptor coactivator interlocking domain Phyre2 PDB 1svf chain C Region: 50 - 86 Aligned: 37 Modelled: 37 Confidence: 7.1% Identity: 24% PDB header:viral protein Chain: C: PDB Molecule:protein (fusion glycoprotein); PDBTitle: paramyxovirus sv5 fusion protein core Phyre2 1 d1wa8a1 2 c4iogD_ 3 c3gvmA_ 4 c3zbhC_ 5 c2vs0B_ 6 c4lwsA_ 7 c4lwsB_ 8 c4wj2A_ 9 d1wa8b1 10 c2kg7B_ 11 c4xy3A_ 12 c4i0xA_ 13 c2kg7A_ 14 c3qmlC_ 15 c4af3D_ 16 c2vgpD_ 17 c5jx6C_ 18 d2c52b1 19 d1kbha_ 20 c1svfC_ 21 22 23 24 25 26 27 28