1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	G	P	S	A	A	G	R	A	G	T	A	D	N	V	V	G	V	E	V	T	I	D	G	M	L	V	I	A	D	R	L	H	L	V	D	F	P	V	T	L	G	I	R	P	N	I	P	Q	E	D	L	R	D	I	V	W	E	Q
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	Q	R	D	L	T	A	Q	G	V	L	D	L	H	G	E	P	Q	P	T	V	A	E	M	V	E	T	L	G	R	P	D	R	T	L	E	G	R	W	W	R	R	D	I	G	G	V	M	V	R	F	V	V	C	R	R	G	D	R	H
Secondary structure
SS confidence
Disorder												?	?	?	?	?																													?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	I	A	A	R	D	G	D	M	L	V	L	Q	L	V	A	P	Q	V	G	L	A	G	M	V	T	A	V	L	G	P	A	E	P	A	N	V	E	P	L	T	G	V	A	T	E	L	A	E	C	T	T	A	S	Q	L	T	Q	Y	G
Secondary structure
SS confidence
Disorder																		?											?				?	?	?	?		?					?					?	?	?	?	?	?	?	?	?				?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		I	A	P	A	S	A	R	V	Y	A	E	I	V	G	N	P	T	G	W	V	E	I	V	A	S	Q	R	H	P	G	G	T	T	T	Q	T	D	A	A	A	G	V	L	D	S	K	L	G	R	L	V	S	L	P	R	R	V	G	G	D
Secondary structure
SS confidence
Disorder		?	?											?	?	?	?	?												?	?	?	?	?																						?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.
Sequence		L	Y	G	S	F	L	P	G	T	Q	Q	N	L	E	R	A	L	D	G	L	L	E	L	L	P	A	G	A	W	L	D	H	T	S	D	H	A	Q	A	S	S	R	G
Secondary structure
SS confidence
Disorder																																?		?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 25%) Alpha helix ( 30%) Beta strand ( 26%)

Rank Aligned region

PDB 5vba chain A Region: 16 - 270 Aligned: 240 Modelled: 255 Confidence: 100.0% Identity: 80% PDB header:chaperone, hydrolase Chain: A: PDB Molecule:lysozyme, esx-1 secretion-associated protein espg1 chimera; PDBTitle: structure of espg1 chaperone from the type vii (esx-1) secretion2 system determined with the assistance of n-terminal t4 lysozyme3 fusion Phyre2 PDB 4l4w chain B Region: 19 - 270 Aligned: 249 Modelled: 252 Confidence: 100.0% Identity: 27% PDB header:protein transport Chain: B: PDB Molecule:espg3; PDBTitle: structure of espg3 chaperone from the type vii (esx-3) secretion2 system Phyre2 PDB 4w4i chain A Region: 17 - 266 Aligned: 249 Modelled: 250 Confidence: 100.0% Identity: 24% PDB header:protein transport Chain: A: PDB Molecule:esx-3 secretion-associated protein espg3; PDBTitle: crystal structure of espg3 from the esx-3 type vii secretion system of2 m. tuberculosis Phyre2 PDB 4kxr chain C Region: 19 - 273 Aligned: 241 Modelled: 255 Confidence: 100.0% Identity: 23% PDB header:protein transport Chain: C: PDB Molecule:espg5; PDBTitle: structure of the mycobacterium tuberculosis type vii secretion system2 chaperone espg5 in complex with pe25-ppe41 dimer Phyre2 PDB 4rcl chain B Region: 19 - 270 Aligned: 220 Modelled: 223 Confidence: 100.0% Identity: 28% PDB header:chaperone Chain: B: PDB Molecule:espg3; PDBTitle: structure of espg3 chaperone from the type vii (esx-3) secretion2 system, space group p43212 Phyre2 PDB 2l3a chain A Region: 18 - 34 Aligned: 17 Modelled: 17 Confidence: 19.6% Identity: 12% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution nmr structure of homodimer protein sp_0782 (7-79) from2 streptococcus pneumoniae northeast structural genomics consortium3 target spr104 . Phyre2 PDB 5w4z chain A Region: 23 - 93 Aligned: 65 Modelled: 71 Confidence: 16.1% Identity: 23% PDB header:flavoprotein Chain: A: PDB Molecule:riboflavin lyase; PDBTitle: crystal structure of riboflavin lyase (rcae) with modified fmn and2 substrate riboflavin Phyre2 PDB 3u5g chain K Region: 19 - 43 Aligned: 25 Modelled: 25 Confidence: 15.0% Identity: 24% PDB header:ribosome Chain: K: PDB Molecule:40s ribosomal protein s10-a; PDBTitle: the structure of the eukaryotic ribosome at 3.0 a resolution. this2 entry contains proteins of the 40s subunit, ribosome b Phyre2 PDB 2v4o chain B Region: 240 - 269 Aligned: 30 Modelled: 30 Confidence: 14.3% Identity: 23% PDB header:hydrolase Chain: B: PDB Molecule:multifunctional protein sur e; PDBTitle: crystal structure of salmonella typhimurium sure at 2.752 angstrom resolution in monoclinic form Phyre2 PDB 1qnt chain A domain 1 Region: 254 - 272 Aligned: 19 Modelled: 19 Confidence: 13.3% Identity: 21% Fold: DNA/RNA-binding 3-helical bundle Superfamily: Methylated DNA-protein cysteine methyltransferase, C-terminal domain Family: Methylated DNA-protein cysteine methyltransferase, C-terminal domain Phyre2 PDB 3pm7 chain A Region: 18 - 33 Aligned: 16 Modelled: 16 Confidence: 12.4% Identity: 13% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of ef_3132 protein from enterococcus faecalis at the2 resolution 2a, northeast structural genomics consortium target efr184 Phyre2 PDB 4u5p chain A Region: 244 - 266 Aligned: 23 Modelled: 23 Confidence: 12.0% Identity: 26% PDB header:isomerase Chain: A: PDB Molecule:rhcc; PDBTitle: crystal structure of native rhcc (yp_702633.1) from rhodococcus jostii2 rha1 at 1.78 angstrom Phyre2 PDB 2ltd chain A Region: 18 - 33 Aligned: 16 Modelled: 16 Confidence: 11.7% Identity: 19% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein ydbc; PDBTitle: solution nmr structure of apo ydbc from lactococcus lactis, northeast2 structural genomics consortium (nesg) target kr150 Phyre2 PDB 2vxh chain F Region: 225 - 279 Aligned: 54 Modelled: 55 Confidence: 10.0% Identity: 6% PDB header:oxidoreductase Chain: F: PDB Molecule:chlorite dismutase; PDBTitle: the crystal structure of chlorite dismutase: a detox enzyme2 producing molecular oxygen Phyre2 PDB 1g26 chain A Region: 263 - 270 Aligned: 8 Modelled: 8 Confidence: 9.2% Identity: 63% Fold: Knottins (small inhibitors, toxins, lectins) Superfamily: Granulin repeat Family: Granulin repeat Phyre2 PDB 3obh chain A Region: 18 - 33 Aligned: 16 Modelled: 16 Confidence: 8.9% Identity: 13% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: x-ray crystal structure of protein sp_0782 (7-79) from streptococcus2 pneumoniae. northeast structural genomics consortium target spr104 Phyre2 PDB 5cra chain B Region: 16 - 38 Aligned: 23 Modelled: 23 Confidence: 8.7% Identity: 43% PDB header:hydrolase Chain: B: PDB Molecule:sdea; PDBTitle: structure of the sdea dub domain Phyre2 PDB 3jcm chain K Region: 30 - 64 Aligned: 35 Modelled: 35 Confidence: 8.5% Identity: 17% PDB header:transcription Chain: K: PDB Molecule:u4/u6 small nuclear ribonucleoprotein prp3; PDBTitle: cryo-em structure of the spliceosomal u4/u6.u5 tri-snrnp Phyre2 PDB 2x5k chain O Region: 218 - 228 Aligned: 11 Modelled: 11 Confidence: 8.4% Identity: 18% PDB header:oxidoreductase Chain: O: PDB Molecule:d-erythrose-4-phosphate dehydrogenase; PDBTitle: structure of an active site mutant of the d-erythrose-4-phosphate2 dehydrogenase from e. coli Phyre2 PDB 4dib chain F Region: 218 - 228 Aligned: 11 Modelled: 11 Confidence: 8.3% Identity: 18% PDB header:oxidoreductase Chain: F: PDB Molecule:glyceraldehyde 3-phosphate dehydrogenase; PDBTitle: the crystal structure of glyceraldehyde-3-phosphate dehydrogenase from2 bacillus anthracis str. sterne Phyre2 1 c5vbaA_ 2 c4l4wB_ 3 c4w4iA_ 4 c4kxrC_ 5 c4rclB_ 6 c2l3aA_ 7 c5w4zA_ 8 c3u5gK_ 9 c2v4oB_ 10 d1qnta1 11 c3pm7A_ 12 c4u5pA_ 13 c2ltdA_ 14 c2vxhF_ 15 d1g26a_ 16 c3obhA_ 17 c5craB_ 18 c3jcmK_ 19 c2x5kO_ 20 c4dibF_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59