1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	G	L	R	L	T	T	K	V	Q	V	S	G	W	R	F	L	L	R	R	L	E	H	A	I	V	R	R	D	T	R	M	F	D	D	P	L	Q	F	Y	S	R	S	I	A	L	G	I	V	V	A	V	L	I	L	A	G	A	A	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																?	?			?		?		?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	A	Y	F	K	P	Q	G	K	L	G	G	T	S	L	F	T	D	R	A	T	N	Q	L	Y	V	L	L	S	G	Q	L	H	P	V	Y	N	L	T	S	A	R	L	V	L	G	N	P	A	N	P	A	T	V	K	S	S	E	L	S
Secondary structure
SS confidence
Disorder												?	?																																			?	?	?	?	?			?						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		K	L	P	M	G	Q	T	V	G	I	P	G	A	P	Y	A	T	P	V	S	A	G	S	T	S	I	W	T	L	C	D	T	V	A	R	A	D	S	T	S	P	V	V	Q	T	A	V	I	A	M	P	L	E	I	D	A	S	I	D	P
Secondary structure
SS confidence
Disorder			?																	?	?	?	?	?	?	?							?	?	?	?	?	?	?	?	?	?							?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		L	Q	S	H	E	A	V	L	V	S	Y	Q	G	E	T	W	I	V	T	T	K	G	R	H	A	I	D	L	T	D	R	A	L	T	S	S	M	G	I	P	V	T	A	R	P	T	P	I	S	E	G	M	F	N	A	L	P	D	M	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?																								?	?	?								?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		P	W	Q	L	P	P	I	P	A	A	G	A	P	N	S	L	G	L	P	D	D	L	V	I	G	S	V	F	Q	I	H	T	D	K	G	P	Q	Y	Y	V	V	L	P	D	G	I	A	Q	V	N	A	T	T	A	A	A	L	R	A	T
Secondary structure
SS confidence
Disorder									?	?	?	?	?	?	?	?	?	?	?	?	?																										?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		Q	A	H	G	L	V	A	P	P	A	M	V	P	S	L	V	V	R	I	A	E	R	V	Y	P	S	P	L	P	D	E	P	L	K	I	V	S	R	P	Q	D	P	A	L	C	W	S	W	Q	R	S	A	G	D	Q	S	P	Q	S	T
Secondary structure
SS confidence
Disorder			?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?								?		?	?												?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		V	L	S	G	R	H	L	P	I	S	P	S	A	M	N	M	G	I	K	Q	I	H	G	T	A	T	V	Y	L	D	G	G	K	F	V	A	L	Q	S	P	D	P	R	Y	T	E	S	M	Y	Y	I	D	P	Q	G	V	R	Y	G	V
Secondary structure
SS confidence
Disorder			?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?			?													?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		P	N	A	E	T	A	K	S	L	G	L	S	S	P	Q	N	A	P	W	E	I	V	R	L	L	V	D	G	P	V	L	S	K	D	A	A	L	L	E	H	D	T	L	P	A	D	P	S	P	R	K	V	P	A	G	A	S	G	A	P
Secondary structure
SS confidence
Disorder																												?			?								?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
Sequence
Secondary structure
SS confidence
Disorder
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 38%) Alpha helix ( 20%) Beta strand ( 21%) TM helix ( 4%) (View membrane topology prediction)

Rank Aligned region

PDB 4kk7 chain A Region: 74 - 458 Aligned: 385 Modelled: 385 Confidence: 100.0% Identity: 100% PDB header:protein transport Chain: A: PDB Molecule:esx-1 secretion system protein eccb1; PDBTitle: structure of eccb1 from the type vii (esx-1) secretion system of2 mycobacterium tuberculosis. Phyre2 PDB 5cyu chain A Region: 74 - 458 Aligned: 378 Modelled: 385 Confidence: 100.0% Identity: 63% PDB header:membrane protein Chain: A: PDB Molecule:conserved membrane protein; PDBTitle: structure of the soluble domain of eccb1 from the mycobacterium2 smegmatis esx-1 secretion system. Phyre2 PDB 2fb5 chain A domain 1 Region: 75 - 95 Aligned: 21 Modelled: 21 Confidence: 54.3% Identity: 24% Fold: YojJ-like Superfamily: YojJ-like Family: YojJ-like Phyre2 PDB 6nav chain I Region: 44 - 89 Aligned: 46 Modelled: 46 Confidence: 44.0% Identity: 20% PDB header:structural protein Chain: I: PDB Molecule:m9ud72; PDBTitle: cryo-em reconstruction of sulfolobus islandicus lal14/1 pilus Phyre2 PDB 2k9y chain B Region: 35 - 64 Aligned: 30 Modelled: 30 Confidence: 23.0% Identity: 23% PDB header:transferase Chain: B: PDB Molecule:ephrin type-a receptor 2; PDBTitle: epha2 dimeric structure in the lipidic bicelle at ph 5.0 Phyre2 PDB 2k9y chain A Region: 35 - 64 Aligned: 30 Modelled: 30 Confidence: 23.0% Identity: 23% PDB header:transferase Chain: A: PDB Molecule:ephrin type-a receptor 2; PDBTitle: epha2 dimeric structure in the lipidic bicelle at ph 5.0 Phyre2 PDB 5xef chain A Region: 14 - 35 Aligned: 22 Modelled: 22 Confidence: 22.6% Identity: 14% PDB header:chaperone Chain: A: PDB Molecule:flagellar protein flis; PDBTitle: crystal structure of flagellar chaperone from bacteria Phyre2 PDB 2ciu chain A Region: 75 - 97 Aligned: 23 Modelled: 23 Confidence: 17.6% Identity: 35% PDB header:protein transport Chain: A: PDB Molecule:import inner membrane translocase subunit tim21 PDBTitle: structure of the ims domain of the mitochondrial import2 protein tim21 from s. cerevisiae Phyre2 PDB 1vh6 chain A Region: 14 - 35 Aligned: 22 Modelled: 19 Confidence: 17.3% Identity: 27% Fold: Four-helical up-and-down bundle Superfamily: Flagellar export chaperone FliS Family: Flagellar export chaperone FliS Phyre2 PDB 1vh6 chain A Region: 14 - 35 Aligned: 22 Modelled: 19 Confidence: 17.3% Identity: 27% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:flagellar protein flis; PDBTitle: crystal structure of a flagellar protein Phyre2 PDB 3c1z chain A Region: 74 - 97 Aligned: 24 Modelled: 24 Confidence: 17.0% Identity: 13% PDB header:dna binding protein Chain: A: PDB Molecule:dna integrity scanning protein disa; PDBTitle: structure of the ligand-free form of a bacterial dna damage sensor2 protein Phyre2 PDB 3k1i chain A Region: 14 - 35 Aligned: 22 Modelled: 22 Confidence: 16.4% Identity: 23% PDB header:chaperone Chain: A: PDB Molecule:flagellar protein; PDBTitle: crystal strcture of flis-hp1076 complex in h. pylori Phyre2 PDB 6gyy chain B Region: 75 - 97 Aligned: 23 Modelled: 23 Confidence: 15.8% Identity: 17% PDB header:transferase Chain: B: PDB Molecule:diadenylate cyclase; PDBTitle: crystal structure of daca from staphylococcus aureus, n166c/t172c2 double mutant Phyre2 PDB 6f0k chain A Region: 39 - 75 Aligned: 36 Modelled: 37 Confidence: 13.4% Identity: 17% PDB header:membrane protein Chain: A: PDB Molecule:cytochrome c family protein; PDBTitle: alternative complex iii Phyre2 PDB 6cfw chain E Region: 50 - 66 Aligned: 17 Modelled: 17 Confidence: 12.6% Identity: 35% PDB header:membrane protein Chain: E: PDB Molecule:mbh subunit; PDBTitle: cryoem structure of a respiratory membrane-bound hydrogenase Phyre2 PDB 6ch3 chain B Region: 14 - 35 Aligned: 22 Modelled: 22 Confidence: 10.1% Identity: 27% PDB header:structural protein Chain: B: PDB Molecule:flagellar secretion chaperone flis,flagellin; PDBTitle: crystal structure of the cytoplasmic domain of flha and flis-flic2 complex Phyre2 PDB 2ixs chain B Region: 403 - 431 Aligned: 29 Modelled: 29 Confidence: 10.1% Identity: 17% PDB header:hydrolase Chain: B: PDB Molecule:sdai restriction endonuclease; PDBTitle: structure of sdai restriction endonuclease Phyre2 PDB 2nn6 chain G domain 2 Region: 400 - 414 Aligned: 15 Modelled: 15 Confidence: 9.9% Identity: 27% Fold: Barrel-sandwich hybrid Superfamily: Ribosomal L27 protein-like Family: ECR1 N-terminal domain-like Phyre2 PDB 2mhg chain A Region: 265 - 285 Aligned: 21 Modelled: 21 Confidence: 9.5% Identity: 33% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: nmr structure of protein np_254181.1 from pseudomonas aeruginosa pa01 Phyre2 PDB 1y7m chain A domain 1 Region: 66 - 92 Aligned: 27 Modelled: 27 Confidence: 9.0% Identity: 11% Fold: L,D-transpeptidase catalytic domain-like Superfamily: L,D-transpeptidase catalytic domain-like Family: L,D-transpeptidase catalytic domain-like Phyre2 1 c4kk7A_ 2 c5cyuA_ 3 d2fb5a1 4 c6navI_ 5 c2k9yB_ 6 c2k9yA_ 7 c5xefA_ 8 c2ciuA_ 9 d1vh6a_ 10 c1vh6A_ 11 c3c1zA_ 12 c3k1iA_ 13 c6gyyB_ 14 c6f0kA_ 15 c6cfwE_ 16 c6ch3B_ 17 c2ixsB_ 18 d2nn6g2 19 c2mhgA_ 20 d1y7ma1 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46