1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	E	M	K	T	D	A	A	T	L	A	Q	E	A	G	N	F	E	R	I	S	G	D	L	K	T	Q	I	D	Q	V	E	S	T	A	G	S	L	Q	G	Q	W	R	G	A	A	G	T	A	A	Q	A	A	V	V	R	F	Q	E
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?																																			?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100
Sequence		A	A	N	K	Q	K	Q	E	L	D	E	I	S	T	N	I	R	Q	A	G	V	Q	Y	S	R	A	D	E	E	Q	Q	Q	A	L	S	S	Q	M	G	F
Secondary structure
SS confidence
Disorder																						?	?																?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 17%) Alpha helix ( 88%) Beta strand ( 0%)

Rank Aligned region

PDB 1wa8 chain A domain 1 Region: 2 - 100 Aligned: 99 Modelled: 99 Confidence: 99.9% Identity: 100% Fold: Ferritin-like Superfamily: EsxAB dimer-like Family: ESAT-6 like Phyre2 PDB 3gvm chain A Region: 1 - 94 Aligned: 94 Modelled: 94 Confidence: 99.8% Identity: 13% PDB header:viral protein Chain: A: PDB Molecule:putative uncharacterized protein sag1039; PDBTitle: structure of the homodimeric wxg-100 family protein from streptococcus2 agalactiae Phyre2 PDB 4iog chain D Region: 1 - 86 Aligned: 86 Modelled: 86 Confidence: 99.8% Identity: 29% PDB header:unknown function Chain: D: PDB Molecule:secreted protein esxb; PDBTitle: the crystal structure of a secreted protein esxb (wild-type, in p212 space group) from bacillus anthracis str. sterne Phyre2 PDB 3zbh chain C Region: 7 - 96 Aligned: 90 Modelled: 90 Confidence: 99.8% Identity: 17% PDB header:unknown function Chain: C: PDB Molecule:esxa; PDBTitle: geobacillus thermodenitrificans esxa crystal form i Phyre2 PDB 4lws chain A Region: 3 - 96 Aligned: 94 Modelled: 94 Confidence: 99.8% Identity: 26% PDB header:unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: esxa : esxb (semet) hetero-dimer from thermomonospora curvata Phyre2 PDB 2vs0 chain B Region: 4 - 87 Aligned: 84 Modelled: 84 Confidence: 99.8% Identity: 14% PDB header:cell invasion Chain: B: PDB Molecule:virulence factor esxa; PDBTitle: structural analysis of homodimeric staphylococcal aureus2 virulence factor esxa Phyre2 PDB 1wa8 chain B domain 1 Region: 2 - 95 Aligned: 94 Modelled: 94 Confidence: 99.7% Identity: 15% Fold: Ferritin-like Superfamily: EsxAB dimer-like Family: ESAT-6 like Phyre2 PDB 2kg7 chain B Region: 1 - 96 Aligned: 96 Modelled: 96 Confidence: 99.6% Identity: 16% PDB header:unknown function Chain: B: PDB Molecule:esat-6-like protein esxh; PDBTitle: structure and features of the complex formed by the tuberculosis2 virulence factors rv0287 and rv0288 Phyre2 PDB 4lws chain B Region: 1 - 84 Aligned: 84 Modelled: 84 Confidence: 99.6% Identity: 17% PDB header:unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: esxa : esxb (semet) hetero-dimer from thermomonospora curvata Phyre2 PDB 4i0x chain A Region: 9 - 83 Aligned: 75 Modelled: 75 Confidence: 98.8% Identity: 16% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:esat-6-like protein mab_3112; PDBTitle: crystal structure of the mycobacterum abscessus esxef (mab_3112-2 mab_3113) complex Phyre2 PDB 4i0x chain J Region: 5 - 80 Aligned: 75 Modelled: 76 Confidence: 98.4% Identity: 27% PDB header:structural genomics, unknown function Chain: J: PDB Molecule:esat-6-like protein mab_3113; PDBTitle: crystal structure of the mycobacterum abscessus esxef (mab_3112-2 mab_3113) complex Phyre2 PDB 2gts chain A domain 1 Region: 4 - 78 Aligned: 74 Modelled: 75 Confidence: 98.3% Identity: 15% Fold: Ferritin-like Superfamily: HP0062-like Family: HP0062-like Phyre2 PDB 2g38 chain B domain 1 Region: 8 - 86 Aligned: 79 Modelled: 79 Confidence: 97.9% Identity: 16% Fold: Ferritin-like Superfamily: PE/PPE dimer-like Family: PPE Phyre2 PDB 2g38 chain B Region: 8 - 86 Aligned: 79 Modelled: 79 Confidence: 97.9% Identity: 16% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:ppe family protein; PDBTitle: a pe/ppe protein complex from mycobacterium tuberculosis Phyre2 PDB 5xfs chain B Region: 8 - 86 Aligned: 79 Modelled: 79 Confidence: 97.6% Identity: 18% PDB header:protein transport Chain: B: PDB Molecule:ppe family protein ppe15; PDBTitle: crystal structure of pe8-ppe15 in complex with espg5 from m.2 tuberculosis Phyre2 PDB 3ogi chain D Region: 7 - 95 Aligned: 73 Modelled: 72 Confidence: 95.6% Identity: 18% PDB header:structural genomics, unknown function Chain: D: PDB Molecule:putative esat-6-like protein 7; PDBTitle: crystal structure of the mycobacterium tuberculosis h37rv esxop2 complex (rv2346c-rv2347c) Phyre2 PDB 4wj2 chain A Region: 11 - 86 Aligned: 72 Modelled: 76 Confidence: 94.2% Identity: 13% PDB header:unknown function Chain: A: PDB Molecule:antigen mtb48; PDBTitle: mycobacterial protein Phyre2 PDB 3q4h chain B Region: 7 - 83 Aligned: 77 Modelled: 76 Confidence: 93.1% Identity: 17% PDB header:metal transport Chain: B: PDB Molecule:low molecular weight protein antigen 7; PDBTitle: crystal structure of the mycobacterium smegmatis esxgh complex2 (msmeg_0620-msmeg_0621) Phyre2 PDB 4xy3 chain A Region: 11 - 86 Aligned: 71 Modelled: 76 Confidence: 90.2% Identity: 15% PDB header:protein transport Chain: A: PDB Molecule:esx-1 secretion-associated protein espb; PDBTitle: structure of esx-1 secreted protein espb Phyre2 PDB 3h6p chain D Region: 22 - 73 Aligned: 52 Modelled: 52 Confidence: 89.2% Identity: 19% PDB header:structural genomics, unknown function Chain: D: PDB Molecule:esat-6-like protein esxr; PDBTitle: crystal structure of rv3019c-rv3020c from mycobacterium tuberculosis Phyre2 1 d1wa8a1 2 c3gvmA_ 3 c4iogD_ 4 c3zbhC_ 5 c4lwsA_ 6 c2vs0B_ 7 d1wa8b1 8 c2kg7B_ 9 c4lwsB_ 10 c4i0xA_ 11 c4i0xJ_ 12 d2gtsa1 13 d2g38b1 14 c2g38B_ 15 c5xfsB_ 16 c3ogiD_ 17 c4wj2A_ 18 c3q4hB_ 19 c4xy3A_ 20 c3h6pD_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98