1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	R	N	P	L	G	L	R	F	S	T	G	H	A	L	L	A	S	A	L	A	P	P	C	I	I	A	F	L	E	T	R	Y	W	W	A	G	I	A	L	A	S	L	G	V	I	V	A	T	V	T	F	Y	G	R	R	I	T	G	W
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?																		?																						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	A	A	V	Y	A	W	L	R	R	R	R	R	P	P	D	S	S	S	E	P	V	V	G	A	T	V	K	P	G	D	H	V	A	V	R	W	Q	G	E	F	L	V	A	V	I	E	L	I	P	R	P	F	T	P	T	V	I	V	D
Secondary structure
SS confidence
Disorder											?	?	?	?	?	?	?	?	?	?	?	?	?		?	?	?	?	?	?	?	?																												?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	Q	A	H	T	D	D	M	L	D	T	G	L	V	E	E	L	L	S	V	H	C	P	D	L	E	A	D	I	V	S	A	G	Y	R	V	G	N	T	A	A	P	D	V	V	S	L	Y	Q	Q	V	I	G	T	D	P	A	P	A	N
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?																							?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?							?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		R	R	T	W	I	V	L	R	A	D	P	E	R	T	R	K	S	A	Q	R	R	D	E	G	V	A	G	L	A	R	Y	L	V	A	S	A	T	R	I	A	D	R	L	A	S	H	G	V	D	A	V	C	G	R	S	F	D	D	Y	D
Secondary structure
SS confidence
Disorder															?									?		?	?																				?							?						?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		H	A	T	D	I	G	F	V	R	E	K	W	S	M	I	K	G	R	D	A	Y	T	A	A	Y	A	A	P	G	G	P	D	V	W	W	S	A	R	A	D	H	T	I	T	R	V	R	V	A	P	G	M	A	P	Q	S	T	V	L	L
Secondary structure
SS confidence
Disorder		?		?	?	?	?		?	?																							?	?	?				?	?	?								?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		T	T	A	D	K	P	K	T	P	R	G	F	A	R	L	F	G	G	Q	R	P	A	L	Q	G	Q	H	L	V	A	N	R	H	C	Q	L	P	I	G	S	A	G	V	L	V	G	E	T	V	N	R	C	P	V	Y	M	P	F	D	D
Secondary structure
SS confidence
Disorder			?		?	?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		V	D	I	A	L	N	L	G	D	A	Q	T	F	T	Q	F	V	V	R	A	A	A	A	G	A	M	V	T	V	G	P	Q	F	E	E	F	A	R	L	I	G	A	H	I	G	Q	E	V	K	V	A	W	P	N	A	T	T	Y	L	G
Secondary structure
SS confidence
Disorder																								?																															?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.
Sequence		P	H	P	G	I	D	R	V	I	L	R	H	N	V	I	G	T	P	R	H	R	Q	L	P	I	R	R	V	S	P	P	E	E	S	R	Y	Q	M	A	L	P	K
Secondary structure
SS confidence
Disorder																											?	?						?			?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 28%) Alpha helix ( 31%) Beta strand ( 22%) TM helix ( 3%) (View membrane topology prediction)

Rank Aligned region

PDB 4k2b chain A Region: 356 - 430 Aligned: 73 Modelled: 75 Confidence: 53.3% Identity: 25% PDB header:transferase Chain: A: PDB Molecule:ntd biosynthesis operon protein ntda; PDBTitle: crystal structure of ntda from bacillus subtilis in complex with the2 internal aldimine Phyre2 PDB 1z65 chain A Region: 32 - 55 Aligned: 24 Modelled: 24 Confidence: 41.1% Identity: 29% PDB header:unknown function Chain: A: PDB Molecule:prion-like protein doppel; PDBTitle: mouse doppel 1-30 peptide Phyre2 PDB 5zkx chain A Region: 398 - 419 Aligned: 22 Modelled: 22 Confidence: 32.9% Identity: 27% PDB header:viral protein Chain: A: PDB Molecule:envelope glycoprotein; PDBTitle: the postfusion structure of human-infecting bourbon virus envelope2 glycoprotein Phyre2 PDB 3duz chain A Region: 398 - 419 Aligned: 22 Modelled: 22 Confidence: 31.6% Identity: 32% PDB header:viral protein Chain: A: PDB Molecule:major envelope glycoprotein; PDBTitle: crystal structure of the postfusion form of baculovirus2 fusion protein gp64 Phyre2 PDB 4px7 chain A Region: 6 - 53 Aligned: 48 Modelled: 42 Confidence: 31.2% Identity: 19% PDB header:hydrolase Chain: A: PDB Molecule:phosphatidylglycerophosphatase; PDBTitle: crystal structure of lipid phosphatase e. coli pgpb Phyre2 PDB 5xeb chain C Region: 398 - 419 Aligned: 22 Modelled: 22 Confidence: 30.0% Identity: 32% PDB header:viral protein Chain: C: PDB Molecule:envelope glycoprotein; PDBTitle: structure of the envelope glycoprotein of dhori virus Phyre2 PDB 5zl6 chain A Region: 178 - 238 Aligned: 61 Modelled: 61 Confidence: 29.8% Identity: 15% PDB header:isomerase Chain: A: PDB Molecule:histidine racemase; PDBTitle: histidine racemase from leuconostoc mesenteroides subsp. sake nbrc2 102480 Phyre2 PDB 5xea chain B Region: 398 - 419 Aligned: 22 Modelled: 22 Confidence: 28.2% Identity: 32% PDB header:viral protein Chain: B: PDB Molecule:envelope glycoprotein; PDBTitle: structure of thogoto virus envelope glycoprotein Phyre2 PDB 4ecl chain A Region: 178 - 238 Aligned: 61 Modelled: 61 Confidence: 21.5% Identity: 10% PDB header:isomerase Chain: A: PDB Molecule:serine racemase; PDBTitle: crystal structure of the cytoplasmic domain of vancomycin resistance2 serine racemase vantg Phyre2 PDB 5xco chain B Region: 351 - 361 Aligned: 11 Modelled: 11 Confidence: 18.8% Identity: 55% PDB header:hydrolase/hydrolase inhibitor Chain: B: PDB Molecule:ace-arg-arg-arg-arg-cys-pro-leu-tyr-ile-ser-tyr-asp-pro- PDBTitle: crystal structure of human k-ras g12d mutant in complex with gdp and2 cyclic inhibitory peptide Phyre2 PDB 1dml chain A domain 1 Region: 336 - 359 Aligned: 24 Modelled: 24 Confidence: 16.7% Identity: 29% Fold: DNA clamp Superfamily: DNA clamp Family: DNA polymerase processivity factor Phyre2 PDB 2k42 chain B Region: 215 - 230 Aligned: 16 Modelled: 16 Confidence: 15.5% Identity: 38% PDB header:signaling protein Chain: B: PDB Molecule:espfu; PDBTitle: solution structure of the gtpase binding domain of wasp in2 complex with espfu, an ehec effector Phyre2 PDB 3mlq chain H Region: 339 - 362 Aligned: 24 Modelled: 24 Confidence: 15.1% Identity: 17% PDB header:transferase/transcription Chain: H: PDB Molecule:transcription-repair coupling factor; PDBTitle: crystal structure of the thermus thermophilus transcription-repair2 coupling factor rna polymerase interacting domain with the thermus3 aquaticus rna polymerase beta1 domain Phyre2 PDB 1x4k chain A domain 1 Region: 332 - 352 Aligned: 21 Modelled: 21 Confidence: 12.4% Identity: 33% Fold: Glucocorticoid receptor-like (DNA-binding domain) Superfamily: Glucocorticoid receptor-like (DNA-binding domain) Family: LIM domain Phyre2 PDB 3co8 chain B Region: 181 - 238 Aligned: 58 Modelled: 58 Confidence: 11.7% Identity: 12% PDB header:isomerase Chain: B: PDB Molecule:alanine racemase; PDBTitle: crystal structure of alanine racemase from oenococcus oeni Phyre2 PDB 5gy6 chain A Region: 417 - 430 Aligned: 14 Modelled: 14 Confidence: 11.7% Identity: 57% PDB header:hydrolase Chain: A: PDB Molecule:ribonuclease t1; PDBTitle: ribonuclease from hericium erinaceus (rnase he1) Phyre2 PDB 1w0d chain A Region: 412 - 436 Aligned: 25 Modelled: 25 Confidence: 11.7% Identity: 36% Fold: Isocitrate/Isopropylmalate dehydrogenase-like Superfamily: Isocitrate/Isopropylmalate dehydrogenase-like Family: Dimeric isocitrate & isopropylmalate dehydrogenases Phyre2 PDB 2dae chain A Region: 128 - 146 Aligned: 19 Modelled: 19 Confidence: 11.4% Identity: 11% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:kiaa0733 protein; PDBTitle: solution structure of the n-terminal cue domain in the2 human mitogen-activated protein kinase kinase kinase 73 interacting protein 2 (map3k7ip2) Phyre2 PDB 3mb2 chain J Region: 432 - 454 Aligned: 23 Modelled: 23 Confidence: 10.8% Identity: 39% PDB header:isomerase Chain: J: PDB Molecule:4-oxalocrotonate tautomerase family enzyme - beta subunit; PDBTitle: kinetic and structural characterization of a heterohexamer 4-2 oxalocrotonate tautomerase from chloroflexus aurantiacus j-10-fl:3 implications for functional and structural diversity in the4 tautomerase superfamily Phyre2 PDB 4y2w chain A Region: 179 - 238 Aligned: 60 Modelled: 60 Confidence: 10.8% Identity: 17% PDB header:isomerase Chain: A: PDB Molecule:alanine racemase 1; PDBTitle: crystal structure of a thermostable alanine racemase from2 thermoanaerobacter tengcongensis mb4 Phyre2 1 c4k2bA_ 2 c1z65A_ 3 c5zkxA_ 4 c3duzA_ 5 c4px7A_ 6 c5xebC_ 7 c5zl6A_ 8 c5xeaB_ 9 c4eclA_ 10 c5xcoB_ 11 d1dmla1 12 c2k42B_ 13 c3mlqH_ 14 d1x4ka1 15 c3co8B_ 16 c5gy6A_ 17 d1w0da_ 18 c2daeA_ 19 c3mb2J_ 20 c4y2wA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58