1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	T	A	P	H	K	V	A	F	P	A	R	C	A	V	N	I	C	Y	D	K	H	L	C	S	Q	V	F	P	A	G	I	P	V	E	G	F	F	E	G	M	V	E	L	F	D	A	D	L	K	R	K	G	F	D	G	V	A	L	P
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?																																							?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	G	S	Y	E	L	H	K	I	N	G	V	R	L	D	I	N	K	S	L	D	E	L	G	V	Q	D	G	D	T	L	V	L	V	P	R	V	A	G	E	S	F	E	P	Q	Y	E	S	L	S	T	G	L	A	A	M	G	K	W	L
Secondary structure
SS confidence
Disorder													?	?	?	?	?	?	?																			?	?	?	?	?	?													?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	R	D	G	G	D	R	M	F	A	P	V	T	S	L	T	A	A	H	T	A	M	A	I	I	A	M	A	V	G	V	V	L	A	L	T	L	R	T	R	T	I	T	D	S	P	V	P	A	A	M	A	G	G	I	G	V	L	L	V
Secondary structure
SS confidence
Disorder																																				?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		I	G	A	L	V	V	W	W	G	W	R	E	R	R	D	L	F	S	G	F	G	W	L	A	V	V	L	L	A	V	A	A	A	C	A	P	P	G	A	L	G	A	A	H	A	L	I	G	L	V	V	V	V	L	G	A	I	T	I	G
Secondary structure
SS confidence
Disorder									?	?			?																							?		?			?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		V	A	T	R	K	R	W	Q	T	A	V	V	T	A	V	V	T	V	C	G	I	L	A	A	V	A	A	V	R	M	F	R	P	V	S	M	Q	V	L	A	I	C	V	L	V	G	L	L	V	L	I	R	M	T	P	T	V	A	L	W
Secondary structure
SS confidence
Disorder				?	?	?		?	?																							?			?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		V	A	R	V	R	P	P	H	F	G	S	I	T	G	R	D	L	F	A	R	R	A	G	M	P	V	D	T	V	A	P	V	S	E	A	D	A	D	D	E	D	N	E	L	T	D	I	T	A	R	G	T	A	I	A	A	S	A	R	L
Secondary structure
SS confidence
Disorder					?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		V	N	A	V	Q	V	G	M	C	V	G	V	S	L	V	L	P	A	A	V	W	G	V	L	T	P	R	Q	P	W	A	W	L	A	L	L	V	A	G	L	T	V	G	L	F	I	T	Q	G	R	G	F	A	A	K	Y	Q	A	V	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		L	V	C	G	A	S	A	A	V	C	A	G	V	L	K	Y	A	L	D	T	P	K	G	V	Q	T	G	L	L	W	P	A	I	F	V	A	A	F	A	A	L	G	L	A	V	A	L	V	V	P	A	T	R	F	R	P	I	I	R	L
Secondary structure
SS confidence
Disorder																																																	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.
Sequence		T	V	E	W	L	E	V	L	A	M	I	A	L	L	P	A	A	A	A	L	G	G	L	F	A	W	L	R	H
Secondary structure
SS confidence
Disorder																													?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 23%) Alpha helix ( 62%) Beta strand ( 5%) TM helix ( 47%) (View membrane topology prediction)

Rank Aligned region

PDB 4kv3 chain A Region: 11 - 95 Aligned: 85 Modelled: 85 Confidence: 99.7% Identity: 27% PDB header:protein transport Chain: A: PDB Molecule:chimera fusion protein of esx-1 secretion system protein PDBTitle: ubiquitin-like domain of the mycobacterium tuberculosis type vii2 secretion system protein eccd1 as maltose-binding protein fusion Phyre2 PDB 1j8c chain A Region: 3 - 94 Aligned: 79 Modelled: 92 Confidence: 97.4% Identity: 27% Fold: beta-Grasp (ubiquitin-like) Superfamily: Ubiquitin-like Family: Ubiquitin-related Phyre2 PDB 2klc chain A Region: 10 - 101 Aligned: 79 Modelled: 92 Confidence: 97.4% Identity: 23% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:ubiquilin-1; PDBTitle: nmr solution structure of human ubiquitin-like domain of ubiquilin 1,2 northeast structural genomics consortium (nesg) target ht5a Phyre2 PDB 1yqb chain A domain 1 Region: 7 - 101 Aligned: 82 Modelled: 95 Confidence: 97.0% Identity: 23% Fold: beta-Grasp (ubiquitin-like) Superfamily: Ubiquitin-like Family: Ubiquitin-related Phyre2 PDB 4hwi chain B Region: 12 - 98 Aligned: 74 Modelled: 87 Confidence: 96.7% Identity: 19% PDB header:chaperone/apoptosis Chain: B: PDB Molecule:bag family molecular chaperone regulator 1; PDBTitle: crystal structure of atbag1 in complex with hsp70 Phyre2 PDB 2bwf chain A domain 1 Region: 12 - 97 Aligned: 73 Modelled: 86 Confidence: 96.6% Identity: 18% Fold: beta-Grasp (ubiquitin-like) Superfamily: Ubiquitin-like Family: Ubiquitin-related Phyre2 PDB 2kd0 chain A Region: 5 - 93 Aligned: 76 Modelled: 89 Confidence: 96.4% Identity: 13% PDB header:signaling protein Chain: A: PDB Molecule:lrr repeats and ubiquitin-like domain-containing PDBTitle: nmr solution structure of o64736 protein from arabidopsis2 thaliana. northeast structural genomics consortium mega3 target ar3445a Phyre2 PDB 1wx7 chain A domain 1 Region: 4 - 101 Aligned: 85 Modelled: 98 Confidence: 96.3% Identity: 25% Fold: beta-Grasp (ubiquitin-like) Superfamily: Ubiquitin-like Family: Ubiquitin-related Phyre2 PDB 2dzm chain A Region: 11 - 101 Aligned: 79 Modelled: 91 Confidence: 96.2% Identity: 10% PDB header:structural genomics unknown function Chain: A: PDB Molecule:fas-associated factor 1; PDBTitle: solution structure of the ubiquitin-like domain in human2 fas-associated factor 1 (hfaf1) Phyre2 PDB 1wx8 chain A domain 1 Region: 4 - 93 Aligned: 77 Modelled: 90 Confidence: 96.1% Identity: 16% Fold: beta-Grasp (ubiquitin-like) Superfamily: Ubiquitin-like Family: Ubiquitin-related Phyre2 PDB 2kma chain A Region: 13 - 96 Aligned: 72 Modelled: 84 Confidence: 95.8% Identity: 17% PDB header:structural protein Chain: A: PDB Molecule:talin 1; PDBTitle: nmr structure of the f0f1 double domain (residues 1-202) of2 the talin ferm domain Phyre2 PDB 1bt0 chain A Region: 14 - 96 Aligned: 70 Modelled: 83 Confidence: 95.8% Identity: 16% Fold: beta-Grasp (ubiquitin-like) Superfamily: Ubiquitin-like Family: Ubiquitin-related Phyre2 PDB 1v2y chain A Region: 6 - 103 Aligned: 98 Modelled: 98 Confidence: 95.7% Identity: 15% Fold: beta-Grasp (ubiquitin-like) Superfamily: Ubiquitin-like Family: Ubiquitin-related Phyre2 PDB 1v86 chain A Region: 4 - 101 Aligned: 84 Modelled: 98 Confidence: 95.5% Identity: 15% Fold: beta-Grasp (ubiquitin-like) Superfamily: Ubiquitin-like Family: Ubiquitin-related Phyre2 PDB 2dzi chain A Region: 6 - 97 Aligned: 79 Modelled: 92 Confidence: 95.5% Identity: 19% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:ubiquitin-like protein 4a; PDBTitle: 2dzi/solution structure of the n-terminal ubiquitin-like2 domain in human ubiquitin-like protein 4a (gdx) Phyre2 PDB 1v5o chain A Region: 14 - 105 Aligned: 80 Modelled: 92 Confidence: 95.5% Identity: 19% Fold: beta-Grasp (ubiquitin-like) Superfamily: Ubiquitin-like Family: Ubiquitin-related Phyre2 PDB 2kzr chain A Region: 14 - 104 Aligned: 83 Modelled: 91 Confidence: 95.4% Identity: 11% PDB header:hydrolase Chain: A: PDB Molecule:ubiquitin thioesterase otu1; PDBTitle: solution nmr structure of ubiquitin thioesterase otu1 (ec 3.1.2.-)2 from mus musculus, northeast structural genomics consortium target3 mmt2a Phyre2 PDB 1wy8 chain A domain 1 Region: 14 - 98 Aligned: 72 Modelled: 85 Confidence: 95.4% Identity: 22% Fold: beta-Grasp (ubiquitin-like) Superfamily: Ubiquitin-like Family: Ubiquitin-related Phyre2 PDB 3m63 chain B Region: 14 - 93 Aligned: 67 Modelled: 80 Confidence: 95.3% Identity: 18% PDB header:ligase/protein binding Chain: B: PDB Molecule:ubiquitin domain-containing protein dsk2; PDBTitle: crystal structure of ufd2 in complex with the ubiquitin-like (ubl)2 domain of dsk2 Phyre2 PDB 3goe chain A Region: 11 - 94 Aligned: 71 Modelled: 71 Confidence: 95.3% Identity: 13% PDB header:recombination, replication Chain: A: PDB Molecule:dna repair protein rad60; PDBTitle: molecular mimicry of sumo promotes dna repair Phyre2 1 c4kv3A_ 2 d1j8ca_ 3 c2klcA_ 4 d1yqba1 5 c4hwiB_ 6 d2bwfa1 7 c2kd0A_ 8 d1wx7a1 9 c2dzmA_ 10 d1wx8a1 11 c2kmaA_ 12 d1bt0a_ 13 d1v2ya_ 14 d1v86a_ 15 c2dziA_ 16 d1v5oa_ 17 c2kzrA_ 18 d1wy8a1 19 c3m63B_ 20 c3goeA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131