1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	P	D	P	G	W	A	A	R	T	P	E	A	N	D	L	L	L	T	A	G	T	G	V	G	T	H	L	A	N	Q	T	A	W	T	T	L	G	A	S	H	H	A	S	G	V	A	S	A	I	N	T	A	A	T	A	A	S	W	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?						?						?					?	?																?														?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	V	G	S	A	A	S	A	L	N	V	T	M	L	N	A	T	L	H	G	L	A	G	W	V	D	V	K	P	A	V	V	S	T	A	I	A	A	F	E	T	A	N	A	A	M	R	P	A	P	E	C	M	E	N	R	D	E	W	G
Secondary structure
SS confidence
Disorder		?	?	?																			?	?		?	?	?	?	?	?	?	?												?	?	?	?	?						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	D	N	A	I	N	P	S	V	L	W	T	L	T	P	R	I	V	S	L	D	V	E	Y	F	G	V	M	W	P	N	N	A	A	V	G	A	T	Y	G	G	V	L	A	A	L	A	E	S	L	A	I	P	P	P	V	A	T	M	G
Secondary structure
SS confidence
Disorder				?		?	?		?	?						?																																			?		?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	S	P	A	A	P	A	Q	A	A	A	A	V	G	Q	A	A	A	E	A	A	A	G	D	G	M	R	S	A	Y	Q	G	V	Q	A	G	S	T	G	A	G	Q	S	T	S	A	G	E	N	F	G	N	Q	L	S	T	F	M	Q	P
Secondary structure
SS confidence
Disorder		?	?	?	?	?										?	?	?	?															?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		M	Q	A	V	M	Q	A	A	P	Q	A	L	Q	A	P	S	G	L	M	Q	A	P	M	S	A	M	Q	P	L	Q	S	M	V	G	M	F	A	N	P	G	A	L	G	M	G	G	A	A	P	G	A	S	A	A	S	A	A	G	G	I
Secondary structure
SS confidence
Disorder									?	?		?	?	?	?	?	?	?				?	?	?																			?		?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		S	A	A	A	T	E	V	G	A	G	G	G	G	A	A	L	G	G	G	G	M	P	A	T	S	F	T	R	P	V	S	A	F	E	S	G	T	S	G	R	P	V	G	L	R	P	S	G	A	L	G	A	D	V	V	R	A	P	T	T
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?		?	?	?	?					?									?	?	?	?	?		?	?											?	?								?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.
Sequence		T	V	G	G	T	P	I	G	G	M	P	V	G	H	A	A	G	G	H	R	G	S	H	G	K	S	E	Q	A	A	T	V	R	V	V	D	D	R	R
Secondary structure
SS confidence
Disorder		?	?	?	?										?	?	?	?	?	?	?	?	?	?	?	?	?	?	?						?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 41%) Alpha helix ( 61%) Beta strand ( 2%)

Rank Aligned region

PDB 5xfs chain B Region: 5 - 178 Aligned: 171 Modelled: 174 Confidence: 100.0% Identity: 26% PDB header:protein transport Chain: B: PDB Molecule:ppe family protein ppe15; PDBTitle: crystal structure of pe8-ppe15 in complex with espg5 from m.2 tuberculosis Phyre2 PDB 2g38 chain B Region: 6 - 179 Aligned: 171 Modelled: 174 Confidence: 100.0% Identity: 22% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:ppe family protein; PDBTitle: a pe/ppe protein complex from mycobacterium tuberculosis Phyre2 PDB 2g38 chain B domain 1 Region: 6 - 179 Aligned: 171 Modelled: 174 Confidence: 100.0% Identity: 22% Fold: Ferritin-like Superfamily: PE/PPE dimer-like Family: PPE Phyre2 PDB 4xy3 chain A Region: 4 - 178 Aligned: 155 Modelled: 175 Confidence: 100.0% Identity: 11% PDB header:protein transport Chain: A: PDB Molecule:esx-1 secretion-associated protein espb; PDBTitle: structure of esx-1 secreted protein espb Phyre2 PDB 4wj2 chain A Region: 1 - 112 Aligned: 108 Modelled: 112 Confidence: 97.5% Identity: 16% PDB header:unknown function Chain: A: PDB Molecule:antigen mtb48; PDBTitle: mycobacterial protein Phyre2 PDB 2vs0 chain B Region: 24 - 102 Aligned: 79 Modelled: 79 Confidence: 97.5% Identity: 10% PDB header:cell invasion Chain: B: PDB Molecule:virulence factor esxa; PDBTitle: structural analysis of homodimeric staphylococcal aureus2 virulence factor esxa Phyre2 PDB 4iog chain D Region: 24 - 101 Aligned: 78 Modelled: 78 Confidence: 97.3% Identity: 5% PDB header:unknown function Chain: D: PDB Molecule:secreted protein esxb; PDBTitle: the crystal structure of a secreted protein esxb (wild-type, in p212 space group) from bacillus anthracis str. sterne Phyre2 PDB 3gvm chain A Region: 24 - 102 Aligned: 79 Modelled: 79 Confidence: 97.2% Identity: 9% PDB header:viral protein Chain: A: PDB Molecule:putative uncharacterized protein sag1039; PDBTitle: structure of the homodimeric wxg-100 family protein from streptococcus2 agalactiae Phyre2 PDB 3zbh chain C Region: 24 - 102 Aligned: 79 Modelled: 79 Confidence: 97.1% Identity: 9% PDB header:unknown function Chain: C: PDB Molecule:esxa; PDBTitle: geobacillus thermodenitrificans esxa crystal form i Phyre2 PDB 1wa8 chain A domain 1 Region: 24 - 100 Aligned: 77 Modelled: 77 Confidence: 96.1% Identity: 9% Fold: Ferritin-like Superfamily: EsxAB dimer-like Family: ESAT-6 like Phyre2 PDB 4lws chain A Region: 24 - 102 Aligned: 79 Modelled: 76 Confidence: 92.9% Identity: 10% PDB header:unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: esxa : esxb (semet) hetero-dimer from thermomonospora curvata Phyre2 PDB 4lws chain B Region: 24 - 100 Aligned: 77 Modelled: 77 Confidence: 92.5% Identity: 12% PDB header:unknown function Chain: B: PDB Molecule:uncharacterized protein; PDBTitle: esxa : esxb (semet) hetero-dimer from thermomonospora curvata Phyre2 PDB 1wa8 chain B domain 1 Region: 25 - 102 Aligned: 78 Modelled: 78 Confidence: 92.0% Identity: 22% Fold: Ferritin-like Superfamily: EsxAB dimer-like Family: ESAT-6 like Phyre2 PDB 4i0x chain A Region: 27 - 99 Aligned: 73 Modelled: 73 Confidence: 86.8% Identity: 12% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:esat-6-like protein mab_3112; PDBTitle: crystal structure of the mycobacterum abscessus esxef (mab_3112-2 mab_3113) complex Phyre2 PDB 2kg7 chain B Region: 34 - 102 Aligned: 69 Modelled: 69 Confidence: 80.3% Identity: 13% PDB header:unknown function Chain: B: PDB Molecule:esat-6-like protein esxh; PDBTitle: structure and features of the complex formed by the tuberculosis2 virulence factors rv0287 and rv0288 Phyre2 PDB 4i0x chain J Region: 35 - 99 Aligned: 61 Modelled: 65 Confidence: 31.2% Identity: 11% PDB header:structural genomics, unknown function Chain: J: PDB Molecule:esat-6-like protein mab_3113; PDBTitle: crystal structure of the mycobacterum abscessus esxef (mab_3112-2 mab_3113) complex Phyre2 PDB 1ui5 chain A domain 2 Region: 73 - 149 Aligned: 55 Modelled: 75 Confidence: 27.0% Identity: 9% Fold: Tetracyclin repressor-like, C-terminal domain Superfamily: Tetracyclin repressor-like, C-terminal domain Family: Tetracyclin repressor-like, C-terminal domain Phyre2 PDB 1bkv chain A Region: 11 - 26 Aligned: 16 Modelled: 16 Confidence: 17.8% Identity: 31% PDB header:structural protein Chain: A: PDB Molecule:t3-785; PDBTitle: collagen Phyre2 PDB 1bkv chain B Region: 11 - 26 Aligned: 16 Modelled: 16 Confidence: 16.8% Identity: 31% PDB header:structural protein Chain: B: PDB Molecule:t3-785; PDBTitle: collagen Phyre2 PDB 1bkv chain C Region: 11 - 26 Aligned: 16 Modelled: 16 Confidence: 16.8% Identity: 31% PDB header:structural protein Chain: C: PDB Molecule:t3-785; PDBTitle: collagen Phyre2 1 c5xfsB_ 2 c2g38B_ 3 d2g38b1 4 c4xy3A_ 5 c4wj2A_ 6 c2vs0B_ 7 c4iogD_ 8 c3gvmA_ 9 c3zbhC_ 10 d1wa8a1 11 c4lwsA_ 12 c4lwsB_ 13 d1wa8b1 14 c4i0xA_ 15 c2kg7B_ 16 c4i0xJ_ 17 d1ui5a2 18 c1bkvA_ 19 c1bkvB_ 20 c1bkvC_ 21