1

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10

.

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20

.

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30

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40

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50

.

.

.

.

.

.

.

.

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60

Sequence

V

Q

A

A

N

R

R

S

A

D

T

I

C

G

V

T

A

P

A

P

L

P

I

P

R

T

R

S

W

P

A

I

V

V

A

A

I

A

A

V

V

A

V

A

A

L

I

V

A

L

T

N

A

R

P

A

A

T

P

A

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

.

.

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.

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70

.

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80

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90

.

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.

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100

.

.

.

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.

.

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.

.

110

.

.

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.

.

.

.

.

.

120

Sequence

T

T

S

V

P

T

Y

T

A

A

Q

T

A

A

A

Q

R

Q

L

C

D

T

Y

K

L

V

A

H

A

V

P

V

D

T

N

G

S

D

K

A

L

A

R

I

T

L

T

N

A

A

A

I

L

D

N

A

A

A

D

P

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

.

.

.

.

.

.

.

.

.

130

.

.

.

.

.

.

.

.

.

140

.

.

.

.

.

.

.

.

.

Sequence

A

L

D

A

K

H

R

D

A

A

R

A

S

D

R

L

P

H

N

D

R

N

G

E

W

W

H

S

S

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 46%) Alpha helix ( 60%) Beta strand ( 0%) TM helix ( 11%) (View membrane topology prediction)

Rank Aligned region

PDB 1rhg chain A Region: 67 - 85 Aligned: 19 Modelled: 19 Confidence: 14.8% Identity: 47% Fold: 4-helical cytokines Superfamily: 4-helical cytokines Family: Long-chain cytokines Phyre2 PDB 1r44 chain A Region: 143 - 147 Aligned: 5 Modelled: 5 Confidence: 12.9% Identity: 80% Fold: Hedgehog/DD-peptidase Superfamily: Hedgehog/DD-peptidase Family: VanX-like Phyre2 PDB 1kyq chain A domain 2 Region: 90 - 103 Aligned: 14 Modelled: 14 Confidence: 11.8% Identity: 21% Fold: Siroheme synthase middle domains-like Superfamily: Siroheme synthase middle domains-like Family: Siroheme synthase middle domains-like Phyre2 PDB 2fd5 chain A domain 2 Region: 71 - 133 Aligned: 63 Modelled: 63 Confidence: 11.6% Identity: 17% Fold: Tetracyclin repressor-like, C-terminal domain Superfamily: Tetracyclin repressor-like, C-terminal domain Family: Tetracyclin repressor-like, C-terminal domain Phyre2 PDB 4lhf chain A Region: 137 - 146 Aligned: 10 Modelled: 10 Confidence: 11.2% Identity: 40% PDB header:viral protein Chain: A: PDB Molecule:regulatory protein cox; PDBTitle: crystal structure of a dna binding protein from phage p2 Phyre2 PDB 1msz chain A Region: 64 - 95 Aligned: 31 Modelled: 32 Confidence: 9.5% Identity: 10% Fold: IF3-like Superfamily: R3H domain Family: R3H domain Phyre2 PDB 1msz chain A Region: 64 - 95 Aligned: 31 Modelled: 32 Confidence: 9.5% Identity: 10% PDB header:dna binding protein Chain: A: PDB Molecule:dna-binding protein smubp-2; PDBTitle: solution structure of the r3h domain from human smubp-2 Phyre2 PDB 6cfw chain D Region: 31 - 52 Aligned: 22 Modelled: 22 Confidence: 9.3% Identity: 36% PDB header:membrane protein Chain: D: PDB Molecule:mbh subunit; PDBTitle: cryoem structure of a respiratory membrane-bound hydrogenase Phyre2 PDB 2v0x chain B Region: 55 - 94 Aligned: 40 Modelled: 40 Confidence: 9.1% Identity: 25% PDB header:cell cycle Chain: B: PDB Molecule:lamina-associated polypeptide 2 isoforms alpha/zeta; PDBTitle: the dimerization domain of lap2alpha Phyre2 PDB 1kyq chain C Region: 90 - 103 Aligned: 14 Modelled: 14 Confidence: 8.5% Identity: 21% PDB header:oxidoreductase, lyase Chain: C: PDB Molecule:siroheme biosynthesis protein met8; PDBTitle: met8p: a bifunctional nad-dependent dehydrogenase and2 ferrochelatase involved in siroheme synthesis. Phyre2 PDB 1bgc chain A Region: 67 - 85 Aligned: 19 Modelled: 19 Confidence: 8.4% Identity: 37% Fold: 4-helical cytokines Superfamily: 4-helical cytokines Family: Long-chain cytokines Phyre2 PDB 1v2z chain A Region: 78 - 84 Aligned: 7 Modelled: 7 Confidence: 8.4% Identity: 43% Fold: KaiA/RbsU domain Superfamily: KaiA/RbsU domain Family: Circadian clock protein KaiA, C-terminal domain Phyre2 PDB 1r8j chain A domain 1 Region: 78 - 84 Aligned: 7 Modelled: 7 Confidence: 8.2% Identity: 43% Fold: KaiA/RbsU domain Superfamily: KaiA/RbsU domain Family: Circadian clock protein KaiA, C-terminal domain Phyre2 PDB 1r5q chain A Region: 78 - 84 Aligned: 7 Modelled: 7 Confidence: 8.2% Identity: 43% Fold: KaiA/RbsU domain Superfamily: KaiA/RbsU domain Family: Circadian clock protein KaiA, C-terminal domain Phyre2 PDB 1sv1 chain A Region: 78 - 84 Aligned: 7 Modelled: 7 Confidence: 8.1% Identity: 43% Fold: KaiA/RbsU domain Superfamily: KaiA/RbsU domain Family: Circadian clock protein KaiA, C-terminal domain Phyre2 PDB 2lg4 chain A Region: 75 - 84 Aligned: 10 Modelled: 10 Confidence: 8.1% Identity: 30% PDB header:antimicrobial protein Chain: A: PDB Molecule:aurelin; PDBTitle: 3d solution structure of antimicrobial peptide aurelin Phyre2 PDB 3dfz chain B Region: 90 - 103 Aligned: 14 Modelled: 14 Confidence: 7.9% Identity: 21% PDB header:oxidoreductase Chain: B: PDB Molecule:precorrin-2 dehydrogenase; PDBTitle: sirc, precorrin-2 dehydrogenase Phyre2 PDB 2hje chain A domain 1 Region: 68 - 146 Aligned: 74 Modelled: 79 Confidence: 7.1% Identity: 16% Fold: Profilin-like Superfamily: Sensory domain-like Family: LuxQ-periplasmic domain-like Phyre2 PDB 1bge chain A Region: 67 - 85 Aligned: 19 Modelled: 19 Confidence: 6.5% Identity: 37% Fold: 4-helical cytokines Superfamily: 4-helical cytokines Family: Long-chain cytokines Phyre2 PDB 2hyi chain J Region: 138 - 147 Aligned: 10 Modelled: 10 Confidence: 5.9% Identity: 50% PDB header:hydrolase/rna binding protein/rna Chain: J: PDB Molecule:protein casc3; PDBTitle: structure of the human exon junction complex with a trapped2 dead-box helicase bound to rna Phyre2 1 d1rhga_ 2 d1r44a_ 3 d1kyqa2 4 d2fd5a2 5 c4lhfA_ 6 d1msza_ 7 c1mszA_ 8 c6cfwD_ 9 c2v0xB_ 10 c1kyqC_ 11 d1bgca_ 12 d1v2za_ 13 d1r8ja1 14 d1r5qa_ 15 d1sv1a_ 16 c2lg4A_ 17 c3dfzB_ 18 d2hjea1 19 d1bgea_ 20 c2hyiJ_ 21