1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	S	L	L	F	D	F	F	S	L	D	F	I	Y	Y	P	V	S	W	I	M	W	V	W	Y	R	L	F	A	F	V	L	G	P	S	N	F	F	A	W	A	L	S	V	M	F	L	V	F	T	L	R	A	L	L	Y	K	P	F	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?																													?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		R	Q	I	R	T	T	R	Q	M	Q	E	L	Q	P	Q	I	K	A	L	Q	K	K	Y	G	K	D	R	Q	R	M	A	L	E	M	Q	K	L	Q	R	E	H	G	F	N	P	I	L	G	C	L	P	M	L	A	Q	I	P	V	F	L
Secondary structure
SS confidence
Disorder														?											?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		G	L	Y	H	V	L	R	S	F	N	R	T	T	G	G	F	G	Q	P	H	L	S	V	I	E	N	R	L	T	G	N	Y	V	F	S	P	V	D	V	G	H	F	L	D	A	N	L	F	G	A	P	I	G	A	Y	M	T	Q	R	S
Secondary structure
SS confidence
Disorder										?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?		?	?	?	?		?				?													?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	L	D	A	F	V	D	F	S	R	P	A	L	I	A	V	G	V	P	V	M	I	L	A	G	I	A	T	Y	F	N	S	R	A	S	I	A	R	Q	S	A	E	A	A	A	N	P	Q	T	A	M	M	N	K	L	A	L	Y	V	F
Secondary structure
SS confidence
Disorder		?	?	?																																?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		P	L	G	V	V	V	G	G	P	F	L	P	L	A	I	I	L	Y	W	F	S	N	N	I	W	T	F	G	Q	Q	H	Y	V	F	G	M	I	E	K	E	E	E	A	K	K	Q	E	A	V	R	R	R	A	A	N	A	P	A	P	G
Secondary structure
SS confidence
Disorder																																							?	?	?	?		?	?				?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		A	K	P	K	R	S	P	K	T	A	P	A	T	N	A	A	A	P	T	E	A	G	D	T	D	D	G	A	E	S	D	A	S	T	E	R	P	A	D	T	S	N	P	A	R	R	N	S	G	P	S	A	R	T	P	R	P	G	V	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.
Sequence		P	K	K	R	K	R
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 40%) Alpha helix ( 72%) Beta strand ( 0%) TM helix ( 34%) (View membrane topology prediction)

Rank Aligned region

PDB 3wvf chain A Region: 1 - 270 Aligned: 192 Modelled: 213 Confidence: 100.0% Identity: 30% PDB header:chaperone Chain: A: PDB Molecule:membrane protein insertase yidc; PDBTitle: crystal structure of yidc from escherichia coli Phyre2 PDB 3wo6 chain A Region: 6 - 271 Aligned: 196 Modelled: 230 Confidence: 100.0% Identity: 31% PDB header:membrane protein Chain: A: PDB Molecule:membrane protein insertase yidc 2; PDBTitle: crystal structure of yidc from bacillus halodurans (form i) Phyre2 PDB 5y83 chain A Region: 4 - 271 Aligned: 141 Modelled: 153 Confidence: 100.0% Identity: 28% PDB header:transport protein Chain: A: PDB Molecule:membrane protein insertase yidc; PDBTitle: crystal structure of yidc from thermotoga maritima Phyre2 PDB 4utq chain A Region: 11 - 274 Aligned: 114 Modelled: 123 Confidence: 100.0% Identity: 31% PDB header:protein transport Chain: A: PDB Molecule:membrane protein insertase yidc; PDBTitle: a structural model of the active ribosome-bound membrane protein2 insertase yidc Phyre2 PDB 6n3q chain D Region: 34 - 266 Aligned: 126 Modelled: 139 Confidence: 45.2% Identity: 21% PDB header:transport protein Chain: D: PDB Molecule:protein translocation protein sec63; PDBTitle: cryo-em structure of the yeast sec complex Phyre2 PDB 1v54 chain D Region: 70 - 133 Aligned: 64 Modelled: 64 Confidence: 43.5% Identity: 17% Fold: Single transmembrane helix Superfamily: Mitochondrial cytochrome c oxidase subunit IV Family: Mitochondrial cytochrome c oxidase subunit IV Phyre2 PDB 2y69 chain Q Region: 70 - 133 Aligned: 64 Modelled: 64 Confidence: 42.8% Identity: 17% PDB header:electron transport Chain: Q: PDB Molecule:cytochrome c oxidase subunit 4 isoform 1; PDBTitle: bovine heart cytochrome c oxidase re-refined with molecular oxygen Phyre2 PDB 3r45 chain C Region: 77 - 106 Aligned: 29 Modelled: 30 Confidence: 36.7% Identity: 28% PDB header:nuclear protein Chain: C: PDB Molecule:holliday junction recognition protein; PDBTitle: structure of a cenp-a-histone h4 heterodimer in complex with chaperone2 hjurp Phyre2 PDB 2avu chain F Region: 91 - 128 Aligned: 38 Modelled: 38 Confidence: 26.2% Identity: 26% PDB header:transcription activator Chain: F: PDB Molecule:flagellar transcriptional activator flhc; PDBTitle: structure of the escherichia coli flhdc complex, a2 prokaryotic heteromeric regulator of transcription Phyre2 PDB 2avu chain E domain 1 Region: 91 - 134 Aligned: 44 Modelled: 44 Confidence: 24.3% Identity: 25% Fold: FlhC-like Superfamily: FlhC-like Family: FlhC-like Phyre2 PDB 5day chain A Region: 58 - 101 Aligned: 44 Modelled: 44 Confidence: 22.2% Identity: 9% PDB header:chaperone Chain: A: PDB Molecule:nap1-related protein 1; PDBTitle: the structure of nap1-related protein(nrp1) in arabidopsis Phyre2 PDB 6k1h chain F Region: 76 - 112 Aligned: 37 Modelled: 37 Confidence: 21.9% Identity: 8% PDB header:protein transport Chain: F: PDB Molecule:pts system mannose-specific eiid component; PDBTitle: structure of membrane protein Phyre2 PDB 1ryk chain A Region: 78 - 104 Aligned: 27 Modelled: 27 Confidence: 21.5% Identity: 15% Fold: SAM domain-like Superfamily: Hypothetical protein YjbJ Family: Hypothetical protein YjbJ Phyre2 PDB 6iu8 chain C Region: 75 - 105 Aligned: 31 Modelled: 31 Confidence: 19.3% Identity: 19% PDB header:metal transport Chain: C: PDB Molecule:vit1; PDBTitle: crystal structure of cytoplasmic metal binding domain with cobalt ions Phyre2 PDB 2hyx chain A Region: 70 - 104 Aligned: 35 Modelled: 35 Confidence: 18.9% Identity: 14% PDB header:unknown function Chain: A: PDB Molecule:protein dipz; PDBTitle: structure of the c-terminal domain of dipz from mycobacterium2 tuberculosis Phyre2 PDB 2do5 chain A Region: 70 - 103 Aligned: 34 Modelled: 34 Confidence: 18.7% Identity: 24% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:splicing factor 3b subunit 2; PDBTitle: solution structure of the sap domain of human splicing2 factor 3b subunit 2 Phyre2 PDB 1p58 chain C Region: 2 - 51 Aligned: 47 Modelled: 50 Confidence: 16.9% Identity: 15% PDB header:virus Chain: C: PDB Molecule:major envelope protein e; PDBTitle: complex organization of dengue virus membrane proteins as revealed by2 9.5 angstrom cryo-em reconstruction Phyre2 PDB 6gc1 chain A Region: 70 - 104 Aligned: 35 Modelled: 35 Confidence: 16.7% Identity: 14% PDB header:unknown function Chain: A: PDB Molecule:nhl repeat-containing protein 2; PDBTitle: crystal structure of trx-like and nhl repeat containing domains of2 human nhlrc2 Phyre2 PDB 4l0n chain G Region: 66 - 95 Aligned: 30 Modelled: 30 Confidence: 14.4% Identity: 27% PDB header:transferase Chain: G: PDB Molecule:serine/threonine-protein kinase 3; PDBTitle: crystal structure of stk3 (mst2) sarah domain Phyre2 PDB 2jo8 chain B Region: 66 - 94 Aligned: 29 Modelled: 29 Confidence: 14.1% Identity: 24% PDB header:transferase Chain: B: PDB Molecule:serine/threonine-protein kinase 4; PDBTitle: solution structure of c-terminal domain of human mammalian2 sterile 20-like kinase 1 (mst1) Phyre2 1 c3wvfA_ 2 c3wo6A_ 3 c5y83A_ 4 c4utqA_ 5 c6n3qD_ 6 d1v54d_ 7 c2y69Q_ 8 c3r45C_ 9 c2avuF_ 10 d2avue1 11 c5dayA_ 12 c6k1hF_ 13 d1ryka_ 14 c6iu8C_ 15 c2hyxA_ 16 c2do5A_ 17 c1p58C_ 18 c6gc1A_ 19 c4l0nG_ 20 c2jo8B_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67