1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	S	V	Y	K	H	A	P	S	R	V	R	L	R	Q	T	R	S	T	V	V	K	G	R	S	G	S	L	S	W	R	R	V	R	T	G	D	L	G	L	A	V	W	G	G	R	E	E	Y	R	A	V	K	P	G	T	P	G	I	Q
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?								?	?	?	?	?	?	?		?		?																												?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		P	K	G	D	M	M	T	V	T	V	V	D	A	G	P	G	R	V	S	R	S	V	E	V	A	A	P	A	A	E	L	F	A	I	V	A	D	P	R	R	H	R	E	L	D	G	S	G	T	V	R	G	N	I	K	V	P	A	K	L
Secondary structure
SS confidence
Disorder		?	?	?	?	?		?	?	?	?		?	?	?	?	?																																						?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		V	V	G	S	K	F	S	T	K	M	K	L	F	G	L	P	Y	R	I	T	S	R	V	T	A	L	K	P	N	E	L	V	E	W	S	H	P	L	G	H	R	W	R	W	E	F	E	S	L	S	P	T	L	T	R	V	T	E	T	F
Secondary structure
SS confidence
Disorder																?																																				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.
Sequence		D	Y	H	A	A	G	A	I	K	N	G	L	K	F	Y	E	M	T	G	F	A	K	S	N	A	A	G	I	E	A	T	L	A	K	L	S	D	Q	Y	A	R	G	R	A
Secondary structure
SS confidence
Disorder					?	?	?	?	?	?	?		?	?	?	?	?	?	?	?	?	?	?	?	?																?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 32%) Alpha helix ( 12%) Beta strand ( 48%)

Rank Aligned region

PDB 4xrw chain A Region: 76 - 224 Aligned: 139 Modelled: 149 Confidence: 99.8% Identity: 18% PDB header:lyase Chain: A: PDB Molecule:bexl; PDBTitle: crystal structure of the di-domain aro/cyc bexl from the be-7585a2 biosynthetic pathway Phyre2 PDB 5wox chain A Region: 74 - 220 Aligned: 143 Modelled: 147 Confidence: 99.7% Identity: 16% PDB header:unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: nmr solution structure of kany protein (ms6282) using two 4d-spectra Phyre2 PDB 2m47 chain A Region: 73 - 224 Aligned: 146 Modelled: 152 Confidence: 99.7% Identity: 23% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein cgl2373; PDBTitle: solution nmr structure of the polyketide_cyc-like protein cgl2372 from2 corynebacterium glutamicum, northeast structural genomics consortium3 target cgr160 Phyre2 PDB 4xrt chain B Region: 78 - 221 Aligned: 127 Modelled: 129 Confidence: 99.7% Identity: 15% PDB header:lyase Chain: B: PDB Molecule:stfq aromatase/cyclase; PDBTitle: crystal structure of the di-domain aro/cyc stfq from the steffimycin2 biosynthetic pathway Phyre2 PDB 2lf2 chain A Region: 62 - 223 Aligned: 152 Modelled: 162 Confidence: 99.7% Identity: 15% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution nmr structure of the ahsa1-like protein chu_1110 from2 cytophaga hutchinsonii, northeast structural genomics consortium3 target chr152 Phyre2 PDB 3tfz chain B Region: 76 - 221 Aligned: 139 Modelled: 142 Confidence: 99.7% Identity: 20% PDB header:biosynthetic protein Chain: B: PDB Molecule:cyclase; PDBTitle: crystal structure of zhui aromatase/cyclase from streptomcyes sp.2 r1128 Phyre2 PDB 3pu2 chain G Region: 75 - 220 Aligned: 135 Modelled: 145 Confidence: 99.7% Identity: 16% PDB header:structure genomics, unknown function Chain: G: PDB Molecule:uncharacterized protein; PDBTitle: crystal structure of the q3j4m4_rhos4 protein from rhodobacter2 sphaeroides. northeast structural genomics consortium target rhr263. Phyre2 PDB 2l9p chain A Region: 71 - 222 Aligned: 141 Modelled: 152 Confidence: 99.7% Identity: 13% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution nmr structure of q5hli9 from staphylococcus epidermidis,2 northeast structural genomics consortium target ser147 Phyre2 PDB 1xuv chain A Region: 67 - 223 Aligned: 147 Modelled: 157 Confidence: 99.7% Identity: 15% Fold: TBP-like Superfamily: Bet v1-like Family: AHSA1 domain Phyre2 PDB 2kf2 chain A Region: 75 - 223 Aligned: 145 Modelled: 148 Confidence: 99.6% Identity: 13% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:putative polyketide cyclase; PDBTitle: solution nmr structure of of streptomyces coelicolor2 polyketide cyclase sco5315. northeast structural genomics3 consortium target rr365 Phyre2 PDB 2l8o chain A Region: 76 - 222 Aligned: 133 Modelled: 147 Confidence: 99.6% Identity: 18% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution structure of chr148 from cytophaga hutchinsonii, northeast2 structural genomics consortium target chr148 Phyre2 PDB 1z94 chain A domain 1 Region: 75 - 222 Aligned: 135 Modelled: 148 Confidence: 99.6% Identity: 14% Fold: TBP-like Superfamily: Bet v1-like Family: AHSA1 domain Phyre2 PDB 2b79 chain A domain 1 Region: 77 - 220 Aligned: 132 Modelled: 144 Confidence: 99.6% Identity: 12% Fold: TBP-like Superfamily: Bet v1-like Family: Smu440-like Phyre2 PDB 3uid chain A Region: 66 - 220 Aligned: 144 Modelled: 155 Confidence: 99.6% Identity: 19% PDB header:unknown function Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: crystal structure of protein ms6760 from mycobacterium smegmatis Phyre2 PDB 1xfs chain A Region: 78 - 224 Aligned: 138 Modelled: 145 Confidence: 99.6% Identity: 12% Fold: TBP-like Superfamily: Bet v1-like Family: AHSA1 domain Phyre2 PDB 2d4r chain A domain 1 Region: 77 - 222 Aligned: 139 Modelled: 146 Confidence: 99.6% Identity: 14% Fold: TBP-like Superfamily: Bet v1-like Family: oligoketide cyclase/dehydrase-like Phyre2 PDB 2lgh chain A Region: 77 - 222 Aligned: 132 Modelled: 146 Confidence: 99.6% Identity: 15% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution nmr structure of the ahsa1-like protein aha_2358 from2 aeromonas hydrophila refined with nh rdcs, northeast structural3 genomics consortium target ahr99. Phyre2 PDB 2rer chain A domain 1 Region: 75 - 221 Aligned: 140 Modelled: 142 Confidence: 99.5% Identity: 11% Fold: TBP-like Superfamily: Bet v1-like Family: oligoketide cyclase/dehydrase-like Phyre2 PDB 5z8o chain A Region: 76 - 223 Aligned: 140 Modelled: 143 Confidence: 99.5% Identity: 17% PDB header:unknown function Chain: A: PDB Molecule:cyclase/dehydrase; PDBTitle: structural of start superfamily protein msmeg_0129 from mycobacterium2 smegmatis Phyre2 PDB 2ldk chain A Region: 66 - 224 Aligned: 148 Modelled: 159 Confidence: 99.5% Identity: 16% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:uncharacterized protein; PDBTitle: solution nmr structure of protein aaur_3427 from arthrobacter2 aurescens, northeast structural genomics consortium target aar96 Phyre2 1 c4xrwA_ 2 c5woxA_ 3 c2m47A_ 4 c4xrtB_ 5 c2lf2A_ 6 c3tfzB_ 7 c3pu2G_ 8 c2l9pA_ 9 d1xuva_ 10 c2kf2A_ 11 c2l8oA_ 12 d1z94a1 13 d2b79a1 14 c3uidA_ 15 d1xfsa_ 16 d2d4ra1 17 c2lghA_ 18 d2rera1 19 c5z8oA_ 20 c2ldkA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99