1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	M	T	L	K	V	A	I	G	P	Q	N	A	F	V	L	R	Q	G	I	R	R	E	Y	V	L	V	I	V	A	L	C	G	I	A	D	G	A	L	I	A	A	G	V	G	G	F	A	A	L	I	H	A	H	P	N	M	T	L	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	R	F	G	G	A	A	F	L	I	G	Y	A	L	L	A	A	R	N	A	W	R	P	S	G	L	V	P	S	E	S	G	P	A	A	L	I	G	V	V	Q	M	C	L	V	V	T	F	L	N	P	H	V	Y	L	D	T	V	V	L
Secondary structure
SS confidence
Disorder																				?		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		I	G	A	L	A	N	E	E	S	D	L	R	W	F	F	G	A	G	A	W	A	A	S	V	V	W	F	A	V	L	G	F	S	A	G	R	L	Q	P	F	F	A	T	P	A	A	W	R	I	L	D	A	L	V	A	V	T	M	I	G
Secondary structure
SS confidence
Disorder				?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.
Sequence		V	A	V	V	V	L	V	T	S	P	S	V	P	T	A	N	V	A	L	I	I
Secondary structure
SS confidence
Disorder									?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 21%) Alpha helix ( 77%) Beta strand ( 0%) TM helix ( 53%) (View membrane topology prediction)

Rank Aligned region

PDB 5vkv chain A Region: 21 - 195 Aligned: 172 Modelled: 175 Confidence: 99.0% Identity: 14% PDB header:oxidoreductase Chain: A: PDB Molecule:cytochrome c-type biogenesis protein ccda; PDBTitle: solution nmr structure of the membrane electron transporter ccda Phyre2 PDB 2n4x chain A Region: 21 - 189 Aligned: 158 Modelled: 169 Confidence: 96.7% Identity: 10% PDB header:membrane protein Chain: A: PDB Molecule:cytochrome c-type biogenesis protein (ccda); PDBTitle: structure of the transmembrane electron transporter ccda Phyre2 PDB 5xyv chain C Region: 74 - 112 Aligned: 33 Modelled: 39 Confidence: 41.1% Identity: 9% PDB header:protein binding Chain: C: PDB Molecule:protein deadlock; PDBTitle: crystal structure of drosophila melanogaster rhino chromoshadow domain2 in complex with deadlock n-terminal domain Phyre2 PDB 2knc chain A Region: 55 - 92 Aligned: 38 Modelled: 38 Confidence: 12.1% Identity: 16% PDB header:cell adhesion Chain: A: PDB Molecule:integrin alpha-iib; PDBTitle: platelet integrin alfaiib-beta3 transmembrane-cytoplasmic2 heterocomplex Phyre2 PDB 2lkg chain A Region: 104 - 151 Aligned: 48 Modelled: 48 Confidence: 7.8% Identity: 8% PDB header:signaling protein Chain: A: PDB Molecule:acetylcholine receptor; PDBTitle: wsa major conformation Phyre2 PDB 1px5 chain A Region: 190 - 198 Aligned: 9 Modelled: 9 Confidence: 5.6% Identity: 56% PDB header:transferase Chain: A: PDB Molecule:2'-5'-oligoadenylate synthetase 1; PDBTitle: crystal structure of the 2'-specific and double-stranded2 rna-activated interferon-induced antiviral protein 2'-5'-3 oligoadenylate synthetase Phyre2 PDB 1px5 chain A domain 1 Region: 190 - 198 Aligned: 9 Modelled: 9 Confidence: 5.3% Identity: 56% Fold: PAP/OAS1 substrate-binding domain Superfamily: PAP/OAS1 substrate-binding domain Family: 2'-5'-oligoadenylate synthetase 1, OAS1, second domain Phyre2 1 c5vkvA_ 2 c2n4xA_ 3 c5xyvC_ 4 c2kncA_ 5 c2lkgA_ 6 c1px5A_ 7 d1px5a1