1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	F	T	Q	I	A	A	E	Q	P	D	L	Q	V	P	T	E	E	Q	I	G	S	A	Y	S	R	W	R	R	K	A	R	S	L	S	M	A	T	D	V	G	F	R	M	P	S	V	W	L	A	E	G	H	S	G	V	A	P	V	Y
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	Y	R	F	D	Y	S	T	P	L	L	K	L	L	L	V	R	A	A	H	A	T	E	L	P	Y	V	W	G	N	L	G	G	S	Q	D	P	A	L	K	L	G	D	A	K	A	A	I	A	V	S	R	R	V	R	T	R	W	I	N
Secondary structure
SS confidence
Disorder										?	?																									?	?	?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.
Sequence		F	A	T	R	G	K	P	T	G	P	D	G	E	P	D	W	P	C	Y	E	E	A	H	R	A	C	L	I	I	G	R	R	D	A	V	V	H	D	V	D	A	H	I	R	A	T	W	G	S	K	W
Secondary structure
SS confidence
Disorder											?	?	?	?																						?	?		?											?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 14%) Alpha helix ( 44%) Beta strand ( 6%)

Rank Aligned region

PDB 3biw chain D Region: 3 - 169 Aligned: 166 Modelled: 167 Confidence: 100.0% Identity: 28% PDB header:cell adhesion/cell adhesion Chain: D: PDB Molecule:neuroligin-1; PDBTitle: crystal structure of the neuroligin-1/neurexin-1beta synaptic adhesion2 complex Phyre2 PDB 1p0i chain A Region: 3 - 169 Aligned: 161 Modelled: 167 Confidence: 100.0% Identity: 21% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: Acetylcholinesterase-like Phyre2 PDB 6i2t chain C Region: 3 - 169 Aligned: 162 Modelled: 167 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: C: PDB Molecule:cholinesterase; PDBTitle: cryoem reconstruction of full-length, fully-glycosylated human2 butyrylcholinesterase tetramer Phyre2 PDB 2pm8 chain A Region: 3 - 169 Aligned: 161 Modelled: 167 Confidence: 100.0% Identity: 20% PDB header:hydrolase Chain: A: PDB Molecule:cholinesterase; PDBTitle: crystal structure of recombinant full length human2 butyrylcholinesterase Phyre2 PDB 1f8u chain A Region: 3 - 169 Aligned: 162 Modelled: 167 Confidence: 100.0% Identity: 23% PDB header:hydrolase/toxin Chain: A: PDB Molecule:acetylcholinesterase; PDBTitle: crystal structure of mutant e202q of human acetylcholinesterase2 complexed with green mamba venom peptide fasciculin-ii Phyre2 PDB 1f8u chain A Region: 3 - 169 Aligned: 162 Modelled: 167 Confidence: 100.0% Identity: 23% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: Acetylcholinesterase-like Phyre2 PDB 1ea5 chain A Region: 3 - 169 Aligned: 162 Modelled: 167 Confidence: 100.0% Identity: 19% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: Acetylcholinesterase-like Phyre2 PDB 4bdt chain A Region: 3 - 169 Aligned: 162 Modelled: 167 Confidence: 100.0% Identity: 23% PDB header:hydrolase/inhibitor Chain: A: PDB Molecule:acetylcholinesterase; PDBTitle: human acetylcholinesterase in complex with huprine w and fasciculin 2 Phyre2 PDB 5x61 chain A Region: 3 - 169 Aligned: 162 Modelled: 167 Confidence: 100.0% Identity: 22% PDB header:hydrolase Chain: A: PDB Molecule:acetylcholinesterase; PDBTitle: crystal structure of acetylcholinesterase catalytic subunit of the2 malaria vector anopheles gambiae, 3.4 a Phyre2 PDB 4qww chain A Region: 3 - 169 Aligned: 159 Modelled: 167 Confidence: 100.0% Identity: 25% PDB header:hydrolase/immune system Chain: A: PDB Molecule:acetylcholinesterase; PDBTitle: crystal structure of the fab410-bfache complex Phyre2 PDB 2w6c chain X Region: 3 - 169 Aligned: 159 Modelled: 167 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: X: PDB Molecule:acetylcholinesterase; PDBTitle: ache in complex with a bis-(-)-nor-meptazinol derivative Phyre2 PDB 2ha2 chain A domain 1 Region: 2 - 169 Aligned: 163 Modelled: 168 Confidence: 100.0% Identity: 23% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: Acetylcholinesterase-like Phyre2 PDB 2h7c chain A domain 1 Region: 11 - 169 Aligned: 151 Modelled: 159 Confidence: 100.0% Identity: 31% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: Acetylcholinesterase-like Phyre2 PDB 2ogs chain A Region: 3 - 168 Aligned: 159 Modelled: 166 Confidence: 100.0% Identity: 28% PDB header:hydrolase Chain: A: PDB Molecule:thermostable carboxylesterase est50; PDBTitle: crystal structure of the geobacillus stearothermophilus2 carboxylesterase est55 at ph 6.2 Phyre2 PDB 1dx4 chain A Region: 3 - 169 Aligned: 160 Modelled: 167 Confidence: 100.0% Identity: 19% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: Acetylcholinesterase-like Phyre2 PDB 1ukc chain A Region: 3 - 169 Aligned: 166 Modelled: 167 Confidence: 100.0% Identity: 18% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: Fungal lipases Phyre2 PDB 5a2g chain B Region: 3 - 168 Aligned: 156 Modelled: 166 Confidence: 100.0% Identity: 19% PDB header:hydrolase Chain: B: PDB Molecule:carboxylic ester hydrolase; PDBTitle: an esterase from anaerobic clostridium hathewayi can2 hydrolyze aliphatic aromatic polyesters Phyre2 PDB 1qe3 chain A Region: 12 - 167 Aligned: 142 Modelled: 156 Confidence: 100.0% Identity: 32% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: Acetylcholinesterase-like Phyre2 PDB 4fg5 chain B Region: 14 - 169 Aligned: 151 Modelled: 151 Confidence: 100.0% Identity: 23% PDB header:hydrolase Chain: B: PDB Molecule:e3 alpha-esterase-7 caboxylesterase; PDBTitle: crystal structure of the alpha-esterase-7 carboxylesterase, e3, from2 lucilia cuprina Phyre2 PDB 1f6w chain A Region: 3 - 169 Aligned: 162 Modelled: 167 Confidence: 100.0% Identity: 22% Fold: alpha/beta-Hydrolases Superfamily: alpha/beta-Hydrolases Family: Acetylcholinesterase-like Phyre2 1 c3biwD_ 2 d1p0ia_ 3 c6i2tC_ 4 c2pm8A_ 5 c1f8uA_ 6 d1f8ua_ 7 d1ea5a_ 8 c4bdtA_ 9 c5x61A_ 10 c4qwwA_ 11 c2w6cX_ 12 d2ha2a1 13 d2h7ca1 14 c2ogsA_ 15 d1dx4a_ 16 d1ukca_ 17 c5a2gB_ 18 d1qe3a_ 19 c4fg5B_ 20 d1f6wa_ 21 22 23 24 25 26 27 28 29 30 31 32 33