1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	G	P	P	P	A	A	R	R	R	E	G	E	P	D	N	Q	D	P	A	G	L	L	T	D	K	Y	E	L	T	M	L	A	A	A	L	R	D	G	S	A	N	R	P	T	T	F	E	V	F	A	R	R	L	P	T	G	R	R	Y
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	V	V	A	G	T	G	R	L	L	E	A	L	P	Q	F	R	F	D	A	D	A	C	E	L	L	A	Q	F	L	D	P	A	T	V	R	Y	L	R	E	F	R	F	R	G	D	I	D	G	Y	A	E	G	E	L	Y	F	P	G	S
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		P	V	L	S	V	R	G	S	F	A	E	C	V	L	L	E	T	L	V	L	S	I	F	N	H	D	T	A	I	A	S	A	A	A	R	M	V	S	A	A	G	G	R	P	L	I	E	M	G	S	R	R	T	H	E	R	A	A	V	A
Secondary structure
SS confidence
Disorder																																																					?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	A	R	A	A	Y	I	A	G	F	A	A	S	S	N	L	A	A	Q	R	R	Y	G	V	P	A	H	G	T	A	A	H	A	F	T	M	L	H	A	Q	H	G	G	P	T	E	L	A	E	R	A	A	F	R	A	Q	V	E	A	L
Secondary structure
SS confidence
Disorder		?	?																																							?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		G	P	G	T	T	L	L	V	D	T	Y	D	V	T	T	G	V	A	N	A	V	A	A	A	G	A	E	L	G	A	I	R	I	D	S	G	E	L	G	V	L	A	R	Q	A	R	E	Q	L	D	R	L	G	A	T	R	T	R	I	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		V	S	G	D	L	D	E	F	S	I	A	A	L	R	G	E	P	V	D	S	Y	G	V	G	T	S	L	V	T	G	S	G	A	P	T	A	N	M	V	Y	K	L	V	E	V	D	G	V	P	V	Q	K	R	S	S	Y	K	E	S	P
Secondary structure
SS confidence
Disorder																																																								?		?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		G	G	R	K	E	A	L	R	R	S	R	A	T	G	T	I	T	E	E	L	V	H	P	A	G	R	P	P	V	I	V	E	P	H	R	V	L	T	L	P	L	V	R	A	G	Q	P	V	A	D	T	S	L	A	A	A	R	Q	L	V
Secondary structure
SS confidence
Disorder		?																												?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.
Sequence		A	S	G	L	R	S	L	P	G	D	G	L	K	L	A	P	G	E	P	A	I	P	T	R	T	I	P	A
Secondary structure
SS confidence
Disorder																								?		?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 8%) Alpha helix ( 40%) Beta strand ( 22%) TM helix ( 4%) (View membrane topology prediction)

Rank Aligned region

PDB 2f7f chain A Region: 16 - 447 Aligned: 422 Modelled: 432 Confidence: 100.0% Identity: 33% PDB header:transferase Chain: A: PDB Molecule:nicotinate phosphoribosyltransferase, putative; PDBTitle: crystal structure of enterococcus faecalis putative nicotinate2 phosphoribosyltransferase, new york structural genomics consortium Phyre2 PDB 4yub chain B Region: 22 - 447 Aligned: 409 Modelled: 426 Confidence: 100.0% Identity: 34% PDB header:ligase Chain: B: PDB Molecule:nicotinate phosphoribosyltransferase; PDBTitle: crystal structure of human nicotinic acid phosphoribosyltransferase Phyre2 PDB 1vlp chain A Region: 11 - 375 Aligned: 359 Modelled: 361 Confidence: 100.0% Identity: 20% PDB header:transferase Chain: A: PDB Molecule:nicotinate phosphoribosyltransferase; PDBTitle: crystal structure of a putative nicotinate phosphoribosyltransferase2 (yor209c, npt1) from saccharomyces cerevisiae at 1.75 a resolution Phyre2 PDB 4hl7 chain A Region: 18 - 376 Aligned: 352 Modelled: 356 Confidence: 100.0% Identity: 21% PDB header:transferase Chain: A: PDB Molecule:nicotinate phosphoribosyltransferase; PDBTitle: crystal structure of nicotinate phosphoribosyltransferase (target2 nysgr-026035) from vibrio cholerae Phyre2 PDB 2im5 chain C Region: 18 - 370 Aligned: 344 Modelled: 353 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: C: PDB Molecule:nicotinate phosphoribosyltransferase; PDBTitle: crystal structure of nicotinate phosphoribosyltransferase from2 porphyromonas gingivalis Phyre2 PDB 1yir chain A Region: 18 - 369 Aligned: 345 Modelled: 352 Confidence: 100.0% Identity: 25% PDB header:transferase Chain: A: PDB Molecule:nicotinate phosphoribosyltransferase 2; PDBTitle: crystal structure of a nicotinate phosphoribosyltransferase Phyre2 PDB 3os4 chain A Region: 18 - 362 Aligned: 338 Modelled: 345 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: A: PDB Molecule:nicotinate phosphoribosyltransferase; PDBTitle: the crystal structure of nicotinate phosphoribosyltransferase from2 yersinia pestis Phyre2 PDB 1ybe chain A Region: 18 - 370 Aligned: 344 Modelled: 353 Confidence: 100.0% Identity: 22% PDB header:transferase Chain: A: PDB Molecule:nicotinate phosphoribosyltransferase; PDBTitle: crystal structure of a nicotinate phosphoribosyltransferase Phyre2 PDB 2i14 chain B Region: 8 - 431 Aligned: 379 Modelled: 397 Confidence: 100.0% Identity: 26% PDB header:transferase Chain: B: PDB Molecule:nicotinate-nucleotide pyrophosphorylase; PDBTitle: crystal structure of nicotinate-nucleotide2 pyrophosphorylase from pyrococcus furiosus Phyre2 PDB 2e5c chain A Region: 17 - 420 Aligned: 386 Modelled: 404 Confidence: 100.0% Identity: 18% PDB header:transferase Chain: A: PDB Molecule:nicotinamide phosphoribosyltransferase; PDBTitle: crystal structure of human nmprtase complexed with 5'-phosphoribosyl-2 1'-pyrophosphate Phyre2 PDB 1ytk chain A Region: 8 - 428 Aligned: 375 Modelled: 386 Confidence: 100.0% Identity: 27% PDB header:transferase Chain: A: PDB Molecule:nicotinate phosphoribosyltransferase from thermoplasma PDBTitle: crystal structure of a nicotinate phosphoribosyltransferase from2 thermoplasma acidophilum with nicotinate mononucleotide Phyre2 PDB 2f7f chain A domain 1 Region: 149 - 447 Aligned: 289 Modelled: 299 Confidence: 100.0% Identity: 34% Fold: TIM beta/alpha-barrel Superfamily: Nicotinate/Quinolinate PRTase C-terminal domain-like Family: NadC C-terminal domain-like Phyre2 PDB 2i14 chain A domain 1 Region: 145 - 431 Aligned: 270 Modelled: 287 Confidence: 100.0% Identity: 27% Fold: TIM beta/alpha-barrel Superfamily: Nicotinate/Quinolinate PRTase C-terminal domain-like Family: NadC C-terminal domain-like Phyre2 PDB 1ytd chain A domain 1 Region: 150 - 428 Aligned: 263 Modelled: 279 Confidence: 100.0% Identity: 28% Fold: TIM beta/alpha-barrel Superfamily: Nicotinate/Quinolinate PRTase C-terminal domain-like Family: NadC C-terminal domain-like Phyre2 PDB 1yir chain A domain 1 Region: 149 - 369 Aligned: 221 Modelled: 221 Confidence: 100.0% Identity: 24% Fold: TIM beta/alpha-barrel Superfamily: Nicotinate/Quinolinate PRTase C-terminal domain-like Family: Monomeric nicotinate phosphoribosyltransferase C-terminal domain Phyre2 PDB 1ybe chain A domain 1 Region: 147 - 370 Aligned: 222 Modelled: 224 Confidence: 100.0% Identity: 23% Fold: TIM beta/alpha-barrel Superfamily: Nicotinate/Quinolinate PRTase C-terminal domain-like Family: Monomeric nicotinate phosphoribosyltransferase C-terminal domain Phyre2 PDB 1vlp chain A domain 2 Region: 146 - 370 Aligned: 224 Modelled: 225 Confidence: 100.0% Identity: 21% Fold: TIM beta/alpha-barrel Superfamily: Nicotinate/Quinolinate PRTase C-terminal domain-like Family: Monomeric nicotinate phosphoribosyltransferase C-terminal domain Phyre2 PDB 2f7f chain A domain 2 Region: 16 - 148 Aligned: 133 Modelled: 133 Confidence: 100.0% Identity: 29% Fold: alpha/beta-Hammerhead Superfamily: Nicotinate/Quinolinate PRTase N-terminal domain-like Family: NadC N-terminal domain-like Phyre2 PDB 1x1o chain C Region: 10 - 343 Aligned: 273 Modelled: 303 Confidence: 100.0% Identity: 23% PDB header:transferase Chain: C: PDB Molecule:nicotinate-nucleotide pyrophosphorylase; PDBTitle: crystal structure of project id tt0268 from thermus thermophilus hb8 Phyre2 PDB 2b7p chain A Region: 42 - 343 Aligned: 245 Modelled: 275 Confidence: 100.0% Identity: 19% PDB header:transferase Chain: A: PDB Molecule:probable nicotinate-nucleotide pyrophosphorylase; PDBTitle: crystal structure of quinolinic acid phosphoribosyltransferase from2 helicobacter pylori with phthalic acid Phyre2 1 c2f7fA_ 2 c4yubB_ 3 c1vlpA_ 4 c4hl7A_ 5 c2im5C_ 6 c1yirA_ 7 c3os4A_ 8 c1ybeA_ 9 c2i14B_ 10 c2e5cA_ 11 c1ytkA_ 12 d2f7fa1 13 d2i14a1 14 d1ytda1 15 d1yira1 16 d1ybea1 17 d1vlpa2 18 d2f7fa2 19 c1x1oC_ 20 c2b7pA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197