1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	D	S	A	G	S	D	L	T	R	H	T	A	E	V	P	L	I	D	Q	H	V	H	G	C	W	L	T	E	G	N	R	R	R	F	E	N	A	L	N	E	A	N	T	E	P	L	A	D	F	D	S	G	F	D	S	Q	L	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?																									?											?	?				?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		F	A	V	R	N	H	C	A	P	I	L	G	L	P	R	H	V	D	P	Q	T	Y	W	D	R	R	S	Q	F	S	E	A	E	L	A	R	R	F	L	Q	A	A	G	V	T	D	W	L	V	E	T	G	I	G	Y	D	V	S	G	M
Secondary structure
SS confidence
Disorder																															?																									?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		A	S	V	A	G	L	G	E	L	S	G	S	H	A	H	E	V	V	R	L	E	Q	V	A	E	Q	A	V	Q	A	S	G	D	Y	A	S	A	F	N	E	I	L	R	R	R	A	A	T	A	V	A	T	K	S	I	L	A	Y	R	G
Secondary structure
SS confidence
Disorder																														?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	F	D	G	D	L	T	E	P	P	A	A	Q	V	A	E	A	A	K	R	W	R	D	R	G	G	V	R	L	Q	D	R	V	L	L	R	F	G	L	H	Q	A	L	R	L	G	K	P	L	Q	F	H	V	G	F	G	D	R	D	A
Secondary structure
SS confidence
Disorder																									?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		D	L	H	K	A	N	P	L	Y	L	L	D	F	L	R	Q	S	G	N	T	P	I	V	L	L	H	C	Y	P	Y	E	R	E	A	G	Y	L	A	Q	A	F	N	N	V	Y	L	D	G	G	L	S	V	H	Y	L	G	A	R	S	P
Secondary structure
SS confidence
Disorder																																																						?	?			?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		A	F	I	G	R	L	L	E	L	A	P	F	R	K	I	V	Y	S	S	D	G	F	G	P	A	E	L	H	F	L	G	A	T	L	W	R	S	G	I	Q	R	V	L	R	G	F	V	E	R	D	D	W	C	E	T	D	A	L	R	V
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.
Sequence		V	D	L	I	A	H	G	T	A	A	R	I	Y	R	L	G	D	R
Secondary structure
SS confidence
Disorder														?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 9%) Alpha helix ( 51%) Beta strand ( 9%)

Rank Aligned region

PDB 1j5s chain A Region: 1 - 373 Aligned: 370 Modelled: 373 Confidence: 100.0% Identity: 12% Fold: TIM beta/alpha-barrel Superfamily: Metallo-dependent hydrolases Family: Uronate isomerase-like Phyre2 PDB 2q01 chain A Region: 1 - 378 Aligned: 375 Modelled: 378 Confidence: 100.0% Identity: 18% PDB header:isomerase Chain: A: PDB Molecule:uronate isomerase; PDBTitle: crystal structure of glucuronate isomerase from caulobacter crescentus Phyre2 PDB 3iac chain A Region: 1 - 376 Aligned: 373 Modelled: 376 Confidence: 100.0% Identity: 16% PDB header:isomerase Chain: A: PDB Molecule:glucuronate isomerase; PDBTitle: 2.2 angstrom crystal structure of glucuronate isomerase from2 salmonella typhimurium. Phyre2 PDB 4i6v chain A Region: 3 - 374 Aligned: 359 Modelled: 372 Confidence: 100.0% Identity: 16% PDB header:hydrolase Chain: A: PDB Molecule:amidohydrolase 2; PDBTitle: the crystal structure of an amidohydrolase 2 from planctomyces2 limnophilus dsm 3776 Phyre2 PDB 2qpx chain A Region: 8 - 378 Aligned: 357 Modelled: 369 Confidence: 100.0% Identity: 27% PDB header:hydrolase Chain: A: PDB Molecule:predicted metal-dependent hydrolase of the tim-barrel fold; PDBTitle: crystal structure of putative metal-dependent hydrolase (yp_805737.1)2 from lactobacillus casei atcc 334 at 1.40 a resolution Phyre2 PDB 2qee chain C domain 1 Region: 3 - 377 Aligned: 360 Modelled: 375 Confidence: 100.0% Identity: 16% Fold: TIM beta/alpha-barrel Superfamily: Metallo-dependent hydrolases Family: Uronate isomerase-like Phyre2 PDB 3irs chain B Region: 16 - 378 Aligned: 273 Modelled: 289 Confidence: 100.0% Identity: 18% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:uncharacterized protein bb4693; PDBTitle: crystal structure of uncharacterized tim-barrel protein bb4693 from2 bordetella bronchiseptica Phyre2 PDB 2gzx chain B Region: 18 - 374 Aligned: 253 Modelled: 269 Confidence: 99.9% Identity: 18% PDB header:structural genomics, unknown function Chain: B: PDB Molecule:putative tatd related dnase; PDBTitle: crystal structure of the tatd deoxyribonuclease mw0446 from2 staphylococcus aureus. northeast structural genomics consortium3 target zr237. Phyre2 PDB 3cjp chain A Region: 18 - 375 Aligned: 252 Modelled: 252 Confidence: 99.9% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:predicted amidohydrolase, dihydroorotase family; PDBTitle: crystal structure of an uncharacterized amidohydrolase cac3332 from2 clostridium acetobutylicum Phyre2 PDB 4l5p chain D Region: 15 - 376 Aligned: 283 Modelled: 296 Confidence: 99.9% Identity: 16% PDB header:lyase Chain: D: PDB Molecule:5-carboxyvanillate decarboxylase; PDBTitle: crystal structure of 5-carboxyvanillate decarboxylase from2 sphingomonas paucimobilis complexed with 4-hydroxy-3-methoxy-5-3 nitrobenzoic acid Phyre2 PDB 2ffi chain A domain 1 Region: 16 - 376 Aligned: 263 Modelled: 289 Confidence: 99.9% Identity: 16% Fold: TIM beta/alpha-barrel Superfamily: Metallo-dependent hydrolases Family: PP1699/LP2961-like Phyre2 PDB 4hk6 chain D Region: 17 - 375 Aligned: 316 Modelled: 335 Confidence: 99.9% Identity: 14% PDB header:lyase Chain: D: PDB Molecule:uracil-5-carboxylate decarboxylase; PDBTitle: crystal structure of cordyceps militaris idcase in complex with 5-2 nitro-uracil Phyre2 PDB 6omq chain A Region: 13 - 378 Aligned: 301 Modelled: 312 Confidence: 99.9% Identity: 15% PDB header:oxidoreductase Chain: A: PDB Molecule:ptmu3; PDBTitle: crystal structure of ptmu3 complexed with ptm substrate Phyre2 PDB 2wm1 chain A Region: 18 - 376 Aligned: 290 Modelled: 301 Confidence: 99.9% Identity: 14% PDB header:lyase Chain: A: PDB Molecule:2-amino-3-carboxymuconate-6-semialdehyde PDBTitle: the crystal structure of human alpha-amino-beta-2 carboxymuconate-epsilon-semialdehyde decarboxylase in3 complex with 1,3- dihydroxyacetonephosphate suggests a4 regulatory link between nad synthesis and glycolysis Phyre2 PDB 5vn5 chain A Region: 18 - 376 Aligned: 294 Modelled: 325 Confidence: 99.9% Identity: 15% PDB header:hydrolase Chain: A: PDB Molecule:2,2',3-trihydroxy-3'-methoxy-5,5'-dicarboxybiphenyl meta- PDBTitle: crystal structure of ligy from sphingobium sp. strain syk-6 Phyre2 PDB 3ij6 chain A Region: 16 - 374 Aligned: 269 Modelled: 293 Confidence: 99.9% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:uncharacterized metal-dependent hydrolase; PDBTitle: crystal structure of an uncharacterized metal-dependent hydrolase from2 lactobacillus acidophilus Phyre2 PDB 1j6o chain A Region: 17 - 374 Aligned: 252 Modelled: 275 Confidence: 99.9% Identity: 18% Fold: TIM beta/alpha-barrel Superfamily: Metallo-dependent hydrolases Family: TatD Mg-dependent DNase-like Phyre2 PDB 1zzm chain A domain 1 Region: 18 - 376 Aligned: 254 Modelled: 263 Confidence: 99.9% Identity: 17% Fold: TIM beta/alpha-barrel Superfamily: Metallo-dependent hydrolases Family: TatD Mg-dependent DNase-like Phyre2 PDB 2gwg chain A domain 1 Region: 18 - 376 Aligned: 294 Modelled: 312 Confidence: 99.9% Identity: 16% Fold: TIM beta/alpha-barrel Superfamily: Metallo-dependent hydrolases Family: PP1699/LP2961-like Phyre2 PDB 4inf chain A Region: 17 - 375 Aligned: 277 Modelled: 282 Confidence: 99.9% Identity: 12% PDB header:hydrolase Chain: A: PDB Molecule:metal-dependent hydrolase; PDBTitle: crystal structure of amidohydrolase saro_0799 (target efi-505250) from2 novosphingobium aromaticivorans dsm 12444 with bound calcium Phyre2 1 d1j5sa_ 2 c2q01A_ 3 c3iacA_ 4 c4i6vA_ 5 c2qpxA_ 6 d2qeec1 7 c3irsB_ 8 c2gzxB_ 9 c3cjpA_ 10 c4l5pD_ 11 d2ffia1 12 c4hk6D_ 13 c6omqA_ 14 c2wm1A_ 15 c5vn5A_ 16 c3ij6A_ 17 d1j6oa_ 18 d1zzma1 19 d2gwga1 20 c4infA_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150