1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	R	R	G	P	G	R	H	R	L	H	D	A	W	W	T	L	I	L	F	A	V	I	G	V	A	V	L	V	T	A	V	S	F	T	G	S	L	R	S	T	V	P	V	T	L	A	A	D	R	S	G	L	V	M	D	S	G	A	K
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?																																												?	?	?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	M	M	R	G	V	Q	V	G	R	V	A	Q	I	G	R	I	E	W	A	Q	N	G	A	S	L	R	L	E	I	D	P	D	Q	I	R	Y	I	P	A	N	V	E	A	Q	I	S	A	T	T	A	F	G	A	K	F	V	D	L	V
Secondary structure
SS confidence
Disorder																			?	?	?													?	?	?		?												?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		M	P	Q	N	P	S	R	A	R	L	S	A	G	A	V	L	H	S	K	N	V	S	T	E	I	N	T	V	F	E	N	V	V	D	L	L	N	M	I	D	P	L	K	L	N	A	V	L	T	A	V	A	D	A	V	R	G	Q	G	E
Secondary structure
SS confidence
Disorder				?	?	?	?	?	?	?	?			?	?	?	?	?	?	?	?	?	?	?																?																	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		R	I	G	Q	A	T	T	D	L	N	E	V	L	E	A	L	N	A	R	G	D	T	I	G	G	N	W	R	S	L	K	N	F	T	D	T	Y	D	A	A	A	Q	D	I	L	T	I	L	N	A	A	S	T	T	S	A	T	V	V	N
Secondary structure
SS confidence
Disorder																				?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		H	S	T	Q	L	D	A	L	L	L	N	A	I	G	L	S	N	A	G	T	N	L	L	G	S	S	R	D	N	L	V	G	A	A	D	I	L	A	P	T	T	S	L	L	F	K	Y	N	P	E	Y	T	C	F	L	Q	G	A	K	W
Secondary structure
SS confidence
Disorder		?																								?																						?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		Y	L	D	N	G	G	Y	A	A	W	G	G	A	D	G	R	T	L	Q	L	D	V	A	L	L	F	G	N	D	P	Y	V	Y	P	D	N	L	P	V	V	A	A	K	G	G	P	G	G	R	P	G	C	G	P	L	P	D	A	T	H
Secondary structure
SS confidence
Disorder									?	?																?																													?			?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		N	F	P	V	R	Q	L	V	T	N	T	G	W	G	T	G	L	D	I	R	P	N	P	G	I	G	H	P	C	W	A	N	Y	F	P	V	T	R	A	V	P	E	P	P	S	I	R	Q	C	I	P	G	P	A	I	G	P	N	P	A
Secondary structure
SS confidence
Disorder		?			?	?					?				?	?	?		?	?	?	?	?	?	?	?	?	?								?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.
Sequence		A	G	E	Q	P
Secondary structure
SS confidence
Disorder		?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 26%) Alpha helix ( 44%) Beta strand ( 14%) TM helix ( 5%) (View membrane topology prediction)

Rank Aligned region

PDB 6ic4 chain C Region: 13 - 151 Aligned: 135 Modelled: 139 Confidence: 99.9% Identity: 17% PDB header:protein transport Chain: C: PDB Molecule:toluene tolerance efflux transporter (abc superfamily, PDBTitle: cryo-em structure of the a. baumannii mla complex at 8.7 a resolution Phyre2 PDB 5uw8 chain C Region: 39 - 142 Aligned: 100 Modelled: 104 Confidence: 99.7% Identity: 23% PDB header:transport protein Chain: C: PDB Molecule:probable phospholipid abc transporter-binding protein mlad; PDBTitle: structure of e. coli mce protein mlad, core mce domain Phyre2 PDB 5uvn chain F Region: 38 - 160 Aligned: 111 Modelled: 123 Confidence: 99.5% Identity: 18% PDB header:transport protein Chain: F: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 5uvn chain E Region: 38 - 160 Aligned: 111 Modelled: 123 Confidence: 99.5% Identity: 18% PDB header:transport protein Chain: E: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 5uvn chain C Region: 38 - 160 Aligned: 111 Modelled: 123 Confidence: 99.5% Identity: 18% PDB header:transport protein Chain: C: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 5uvn chain A Region: 38 - 160 Aligned: 111 Modelled: 123 Confidence: 99.5% Identity: 18% PDB header:transport protein Chain: A: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 5uvn chain B Region: 38 - 160 Aligned: 111 Modelled: 123 Confidence: 99.5% Identity: 18% PDB header:transport protein Chain: B: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 5uvn chain D Region: 38 - 160 Aligned: 111 Modelled: 123 Confidence: 99.5% Identity: 18% PDB header:transport protein Chain: D: PDB Molecule:paraquat-inducible protein b; PDBTitle: structure of e. coli mce protein pqib, periplasmic domain Phyre2 PDB 3g67 chain A Region: 145 - 308 Aligned: 162 Modelled: 164 Confidence: 94.5% Identity: 7% PDB header:signaling protein Chain: A: PDB Molecule:methyl-accepting chemotaxis protein; PDBTitle: crystal structure of a soluble chemoreceptor from thermotoga2 maritima Phyre2 PDB 1qu7 chain A Region: 146 - 308 Aligned: 161 Modelled: 163 Confidence: 88.2% Identity: 9% PDB header:signaling protein Chain: A: PDB Molecule:methyl-accepting chemotaxis protein i; PDBTitle: four helical-bundle structure of the cytoplasmic domain of a serine2 chemotaxis receptor Phyre2 PDB 5szs chain C Region: 157 - 286 Aligned: 118 Modelled: 127 Confidence: 80.8% Identity: 15% PDB header:viral protein Chain: C: PDB Molecule:spike glycoprotein; PDBTitle: glycan shield and epitope masking of a coronavirus spike protein2 observed by cryo-electron microscopy Phyre2 PDB 6b7n chain C Region: 157 - 286 Aligned: 119 Modelled: 127 Confidence: 79.6% Identity: 14% PDB header:viral protein Chain: C: PDB Molecule:spike protein; PDBTitle: cryo-electron microscopy structure of porcine delta coronavirus spike2 protein in the pre-fusion state Phyre2 PDB 3lnr chain A Region: 162 - 265 Aligned: 104 Modelled: 104 Confidence: 69.7% Identity: 8% PDB header:signaling protein Chain: A: PDB Molecule:aerotaxis transducer aer2; PDBTitle: crystal structure of poly-hamp domains from the p. aeruginosa soluble2 receptor aer2 Phyre2 PDB 2ch7 chain A Region: 180 - 308 Aligned: 129 Modelled: 129 Confidence: 67.9% Identity: 12% PDB header:chemotaxis Chain: A: PDB Molecule:methyl-accepting chemotaxis protein; PDBTitle: crystal structure of the cytoplasmic domain of a bacterial2 chemoreceptor from thermotoga maritima Phyre2 PDB 4n21 chain E Region: 177 - 285 Aligned: 109 Modelled: 109 Confidence: 62.3% Identity: 15% PDB header:viral protein Chain: E: PDB Molecule:gp2 ectodomain; PDBTitle: crystal structure of the gp2 core domain from the california academy2 of science virus Phyre2 PDB 6gaj chain A Region: 144 - 263 Aligned: 118 Modelled: 119 Confidence: 60.3% Identity: 13% PDB header:viral protein Chain: A: PDB Molecule:outer capsid protein sigma-1; PDBTitle: crystal structure of the t1l reovirus sigma1 coiled coil tail (iodide) Phyre2 PDB 1kmi chain Z Region: 180 - 283 Aligned: 104 Modelled: 104 Confidence: 60.0% Identity: 17% PDB header:signaling protein Chain: Z: PDB Molecule:chemotaxis protein chez; PDBTitle: crystal structure of an e.coli chemotaxis protein, chez Phyre2 PDB 3cwg chain A Region: 145 - 277 Aligned: 133 Modelled: 133 Confidence: 58.3% Identity: 8% PDB header:transcription Chain: A: PDB Molecule:signal transducer and activator of transcription PDBTitle: unphosphorylated mouse stat3 core fragment Phyre2 PDB 1st6 chain A domain 4 Region: 173 - 280 Aligned: 108 Modelled: 108 Confidence: 57.4% Identity: 16% Fold: Four-helical up-and-down bundle Superfamily: alpha-catenin/vinculin-like Family: alpha-catenin/vinculin Phyre2 PDB 4hw9 chain E Region: 17 - 99 Aligned: 70 Modelled: 83 Confidence: 57.1% Identity: 16% PDB header:membrane protein Chain: E: PDB Molecule:mechanosensitive channel mscs; PDBTitle: crystal structure of helicobacter pylori mscs (closed state) Phyre2 1 c6ic4C_ 2 c5uw8C_ 3 c5uvnF_ 4 c5uvnE_ 5 c5uvnC_ 6 c5uvnA_ 7 c5uvnB_ 8 c5uvnD_ 9 c3g67A_ 10 c1qu7A_ 11 c5szsC_ 12 c6b7nC_ 13 c3lnrA_ 14 c2ch7A_ 15 c4n21E_ 16 c6gajA_ 17 c1kmiZ_ 18 c3cwgA_ 19 d1st6a4 20 c4hw9E_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99