1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	R	L	P	G	R	H	V	L	Y	A	L	S	A	V	T	M	L	A	A	C	S	S	N	G	A	R	G	G	I	A	S	T	N	M	N	P	T	N	P	P	A	T	A	E	T	A	T	V	S	P	T	P	A	P	Q	S	A	R	T
Secondary structure
SS confidence
Disorder		?	?	?	?	?		?													?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		E	T	W	I	N	L	Q	V	G	D	C	L	A	D	L	P	P	A	D	L	S	R	I	T	V	T	I	V	D	C	A	T	A	H	S	A	E	V	Y	L	R	A	P	V	A	V	D	A	A	V	V	S	M	A	N	R	D	C	A	A
Secondary structure
SS confidence
Disorder																		?	?	?	?	?	?																																	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.
Sequence		G	F	A	P	Y	T	G	Q	S	V	D	T	S	P	Y	S	V	A	Y	L	I	D	S	H	Q	D	R	T	G	A	D	P	T	P	S	T	V	I	C	L	L	Q	P	A	N	G	Q	L	L	T	G	S	A	R	R
Secondary structure
SS confidence
Disorder																														?																				?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 34%) Alpha helix ( 24%) Beta strand ( 24%)

Rank Aligned region

PDB 2cwz chain A domain 1 Region: 91 - 147 Aligned: 57 Modelled: 56 Confidence: 31.1% Identity: 11% Fold: Thioesterase/thiol ester dehydrase-isomerase Superfamily: Thioesterase/thiol ester dehydrase-isomerase Family: TTHA0967-like Phyre2 PDB 6czh chain B Region: 136 - 175 Aligned: 28 Modelled: 40 Confidence: 16.2% Identity: 18% PDB header:de novo protein Chain: B: PDB Molecule:mfap0; PDBTitle: structure of a redesigned beta barrel, mfap0, bound to dfhbi Phyre2 PDB 5ue8 chain B Region: 87 - 99 Aligned: 13 Modelled: 13 Confidence: 9.0% Identity: 38% PDB header:exocytosis Chain: B: PDB Molecule:protein unc-13 homolog a; PDBTitle: the crystal structure of munc13-1 c1c2bmun domain Phyre2 PDB 3izc chain W Region: 87 - 95 Aligned: 9 Modelled: 9 Confidence: 7.7% Identity: 22% PDB header:ribosome Chain: W: PDB Molecule:60s ribosomal protein rpl22 (l22e); PDBTitle: localization of the large subunit ribosomal proteins into a 6.1 a2 cryo-em map of saccharomyces cerevisiae translating 80s ribosome Phyre2 PDB 3j39 chain U Region: 87 - 95 Aligned: 9 Modelled: 9 Confidence: 6.9% Identity: 22% PDB header:ribosome Chain: U: PDB Molecule:60s ribosomal protein l22; PDBTitle: structure of the d. melanogaster 60s ribosomal proteins Phyre2 PDB 3iz5 chain W Region: 87 - 95 Aligned: 9 Modelled: 9 Confidence: 6.7% Identity: 22% PDB header:ribosome Chain: W: PDB Molecule:60s ribosomal protein l22 (l22e); PDBTitle: localization of the large subunit ribosomal proteins into a 5.5 a2 cryo-em map of triticum aestivum translating 80s ribosome Phyre2 PDB 6dmm chain B Region: 64 - 72 Aligned: 9 Modelled: 9 Confidence: 5.6% Identity: 56% PDB header:antimicrobial protein Chain: B: PDB Molecule:neutrophil defensin 4; PDBTitle: crystal structure of the g23a mutant of human alpha defensin hnp4. Phyre2 PDB 6dmm chain F Region: 64 - 72 Aligned: 9 Modelled: 9 Confidence: 5.6% Identity: 56% PDB header:antimicrobial protein Chain: F: PDB Molecule:neutrophil defensin 4; PDBTitle: crystal structure of the g23a mutant of human alpha defensin hnp4. Phyre2 PDB 6dmm chain G Region: 64 - 72 Aligned: 9 Modelled: 9 Confidence: 5.6% Identity: 56% PDB header:antimicrobial protein Chain: G: PDB Molecule:neutrophil defensin 4; PDBTitle: crystal structure of the g23a mutant of human alpha defensin hnp4. Phyre2 PDB 6dmm chain D Region: 64 - 72 Aligned: 9 Modelled: 9 Confidence: 5.6% Identity: 56% PDB header:antimicrobial protein Chain: D: PDB Molecule:neutrophil defensin 4; PDBTitle: crystal structure of the g23a mutant of human alpha defensin hnp4. Phyre2 PDB 6dmq chain G Region: 64 - 72 Aligned: 9 Modelled: 9 Confidence: 5.6% Identity: 56% PDB header:antimicrobial protein Chain: G: PDB Molecule:neutrophil defensin 4; PDBTitle: crystal structure of the t27a mutant of human alpha defensin hnp4. Phyre2 PDB 6dmq chain E Region: 64 - 72 Aligned: 9 Modelled: 9 Confidence: 5.6% Identity: 56% PDB header:antimicrobial protein Chain: E: PDB Molecule:neutrophil defensin 4; PDBTitle: crystal structure of the t27a mutant of human alpha defensin hnp4. Phyre2 PDB 6dmq chain C Region: 64 - 72 Aligned: 9 Modelled: 9 Confidence: 5.6% Identity: 56% PDB header:antimicrobial protein Chain: C: PDB Molecule:neutrophil defensin 4; PDBTitle: crystal structure of the t27a mutant of human alpha defensin hnp4. Phyre2 PDB 6dmq chain H Region: 64 - 72 Aligned: 9 Modelled: 9 Confidence: 5.6% Identity: 56% PDB header:antimicrobial protein Chain: H: PDB Molecule:neutrophil defensin 4; PDBTitle: crystal structure of the t27a mutant of human alpha defensin hnp4. Phyre2 PDB 1zmm chain C Region: 64 - 72 Aligned: 9 Modelled: 9 Confidence: 5.5% Identity: 56% PDB header:antimicrobial protein Chain: C: PDB Molecule:neutrophil defensin 4; PDBTitle: crystal structure of human alpha-defensin-4 Phyre2 PDB 1zmm chain A Region: 64 - 72 Aligned: 9 Modelled: 9 Confidence: 5.5% Identity: 56% PDB header:antimicrobial protein Chain: A: PDB Molecule:neutrophil defensin 4; PDBTitle: crystal structure of human alpha-defensin-4 Phyre2 PDB 2oqj chain L Region: 63 - 75 Aligned: 13 Modelled: 13 Confidence: 5.4% Identity: 31% PDB header:immune system Chain: L: PDB Molecule:peptide 2g12.1 (acppshvldmrsgtclaaegk); PDBTitle: crystal structure analysis of fab 2g12 in complex with peptide 2g12.1 Phyre2 PDB 6dmm chain H Region: 64 - 72 Aligned: 9 Modelled: 9 Confidence: 5.3% Identity: 56% PDB header:antimicrobial protein Chain: H: PDB Molecule:neutrophil defensin 4; PDBTitle: crystal structure of the g23a mutant of human alpha defensin hnp4. Phyre2 PDB 6dmm chain I Region: 64 - 72 Aligned: 9 Modelled: 9 Confidence: 5.3% Identity: 56% PDB header:antimicrobial protein Chain: I: PDB Molecule:neutrophil defensin 4; PDBTitle: crystal structure of the g23a mutant of human alpha defensin hnp4. Phyre2 PDB 6dmm chain L Region: 64 - 72 Aligned: 9 Modelled: 9 Confidence: 5.3% Identity: 56% PDB header:antimicrobial protein Chain: L: PDB Molecule:neutrophil defensin 4; PDBTitle: crystal structure of the g23a mutant of human alpha defensin hnp4. Phyre2 1 d2cwza1 2 c6czhB_ 3 c5ue8B_ 4 c3izcW_ 5 c3j39U_ 6 c3iz5W_ 7 c6dmmB_ 8 c6dmmF_ 9 c6dmmG_ 10 c6dmmD_ 11 c6dmqG_ 12 c6dmqE_ 13 c6dmqC_ 14 c6dmqH_ 15 c1zmmC_ 16 c1zmmA_ 17 c2oqjL_ 18 c6dmmH_ 19 c6dmmI_ 20 c6dmmL_ 21 22 23 24 25 26 27 28 29 30 31