1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	D	P	A	G	N	P	A	T	G	T	A	R	V	K	R	G	M	A	E	M	L	K	G	G	V	I	M	D	V	V	T	P	E	Q	A	R	I	A	E	G	A	G	A	V	A	V	M	A	L	E	R	V	P	A	D	I	R	A	Q
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?																									?	?	?	?	?	?											?	?	?				?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		G	G	V	S	R	M	S	D	P	D	M	I	E	G	I	I	A	A	V	T	I	P	V	M	A	K	V	R	I	G	H	F	V	E	A	Q	I	L	Q	T	L	G	V	D	Y	I	D	E	S	E	V	L	T	P	A	D	Y	A	H	H
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?													?	?	?	?	?	?	?		?					?		?	?	?	?		?	?		?			?										?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		I	D	K	W	N	F	T	V	P	F	V	C	G	A	T	N	L	G	E	A	L	R	R	I	S	E	G	A	A	M	I	R	S	K	G	E	A	G	T	G	D	V	S	N	A	T	T	H	M	R	A	I	G	G	E	I	R	R	L	T
Secondary structure
SS confidence
Disorder																									?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?											?		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		S	M	S	E	D	E	L	F	V	A	A	K	E	L	Q	A	P	Y	E	L	V	A	E	V	A	R	A	G	K	L	P	V	T	L	F	T	A	G	G	I	A	T	P	A	D	A	A	M	M	M	Q	L	G	A	E	G	V	F	V	G
Secondary structure
SS confidence
Disorder																																					?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.
Sequence		S	G	I	F	K	S	G	A	P	E	H	R	A	A	A	I	V	K	A	T	T	F	F	D	D	P	D	V	L	A	K	V	S	R	G	L	G	E	A	M	V	G	I	N	V	D	E	I	A	V	G	H	R	L	A	Q	R	G	W
Secondary structure
SS confidence
Disorder																																			?	?		?	?		?			?	?	?	?	?	?	?	?	?	?			?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 31%) Alpha helix ( 62%) Beta strand ( 7%)

Rank Aligned region

PDB 4fir chain B Region: 8 - 297 Aligned: 288 Modelled: 290 Confidence: 100.0% Identity: 60% PDB header:lyase Chain: B: PDB Molecule:pyridoxal biosynthesis lyase pdxs; PDBTitle: crystal structure of pyridoxal biosynthesis lyase pdxs from pyrococcus Phyre2 PDB 2zbt chain B Region: 9 - 280 Aligned: 272 Modelled: 272 Confidence: 100.0% Identity: 71% PDB header:lyase Chain: B: PDB Molecule:pyridoxal biosynthesis lyase pdxs; PDBTitle: crystal structure of pyridoxine biosynthesis protein from thermus2 thermophilus hb8 Phyre2 PDB 3fem chain B Region: 12 - 288 Aligned: 277 Modelled: 277 Confidence: 100.0% Identity: 64% PDB header:biosynthetic protein, transferase Chain: B: PDB Molecule:pyridoxine biosynthesis protein snz1; PDBTitle: structure of the synthase subunit pdx1.1 (snz1) of plp synthase from2 saccharomyces cerevisiae Phyre2 PDB 4ads chain F Region: 9 - 282 Aligned: 274 Modelled: 274 Confidence: 100.0% Identity: 58% PDB header:transferase/transferase Chain: F: PDB Molecule:pyridoxine biosynthetic enzyme pdx1 homologue, putative; PDBTitle: crystal structure of plasmodial plp synthase complex Phyre2 PDB 2nv2 chain U Region: 9 - 277 Aligned: 269 Modelled: 269 Confidence: 100.0% Identity: 65% PDB header:lyase/transferase Chain: U: PDB Molecule:pyridoxal biosynthesis lyase pdxs; PDBTitle: structure of the plp synthase complex pdx1/2 (yaad/e) from bacillus2 subtilis Phyre2 PDB 6hye chain F Region: 10 - 280 Aligned: 257 Modelled: 271 Confidence: 100.0% Identity: 68% PDB header:plant protein Chain: F: PDB Molecule:pyridoxal 5'-phosphate synthase subunit pdx1.3; PDBTitle: pdx1.2/pdx1.3 complex (pdx1.3:k97a) Phyre2 PDB 6hxg chain E Region: 12 - 279 Aligned: 252 Modelled: 268 Confidence: 100.0% Identity: 52% PDB header:plant protein Chain: E: PDB Molecule:pyridoxal 5'-phosphate synthase-like subunit pdx1.2; PDBTitle: pdx1.2/pdx1.3 complex (intermediate) Phyre2 PDB 2yzr chain B Region: 21 - 282 Aligned: 262 Modelled: 262 Confidence: 100.0% Identity: 65% PDB header:lyase Chain: B: PDB Molecule:pyridoxal biosynthesis lyase pdxs; PDBTitle: crystal structure of pyridoxine biosynthesis protein from2 methanocaldococcus jannaschii Phyre2 PDB 1znn chain A domain 1 Region: 23 - 276 Aligned: 245 Modelled: 254 Confidence: 100.0% Identity: 66% Fold: TIM beta/alpha-barrel Superfamily: Ribulose-phoshate binding barrel Family: PdxS-like Phyre2 PDB 1znn chain F Region: 23 - 276 Aligned: 245 Modelled: 254 Confidence: 100.0% Identity: 66% PDB header:biosynthetic protein Chain: F: PDB Molecule:plp synthase; PDBTitle: structure of the synthase subunit of plp synthase Phyre2 PDB 1xm3 chain A Region: 89 - 261 Aligned: 169 Modelled: 162 Confidence: 99.7% Identity: 24% Fold: TIM beta/alpha-barrel Superfamily: ThiG-like Family: ThiG-like Phyre2 PDB 3qja chain A Region: 25 - 266 Aligned: 200 Modelled: 204 Confidence: 99.6% Identity: 27% PDB header:lyase Chain: A: PDB Molecule:indole-3-glycerol phosphate synthase; PDBTitle: crystal structure of the mycobacterium tuberculosis indole-3-glycerol2 phosphate synthase (trpc) in apo form Phyre2 PDB 5zjn chain B Region: 18 - 260 Aligned: 187 Modelled: 190 Confidence: 99.6% Identity: 24% PDB header:isomerase Chain: B: PDB Molecule:putative n-acetylmannosamine-6-phosphate 2-epimerase; PDBTitle: structure of n-acetylmannosamine-6-phosphate-2-epimerase from vibrio2 cholerae with n-acetylmannosamine-6-phosphate Phyre2 PDB 5zkn chain A Region: 18 - 260 Aligned: 191 Modelled: 196 Confidence: 99.6% Identity: 24% PDB header:isomerase Chain: A: PDB Molecule:putative n-acetylmannosamine-6-phosphate 2-epimerase; PDBTitle: structure of n-acetylmannosamine-6-phosphate 2-epimerase from2 fusobacterium nucleatum Phyre2 PDB 1yxy chain A domain 1 Region: 15 - 260 Aligned: 195 Modelled: 198 Confidence: 99.5% Identity: 26% Fold: TIM beta/alpha-barrel Superfamily: Ribulose-phoshate binding barrel Family: NanE-like Phyre2 PDB 3q58 chain A Region: 11 - 260 Aligned: 196 Modelled: 204 Confidence: 99.4% Identity: 25% PDB header:isomerase Chain: A: PDB Molecule:n-acetylmannosamine-6-phosphate 2-epimerase; PDBTitle: structure of n-acetylmannosamine-6-phosphate epimerase from salmonella2 enterica Phyre2 PDB 1y0e chain A Region: 33 - 260 Aligned: 173 Modelled: 177 Confidence: 99.4% Identity: 20% Fold: TIM beta/alpha-barrel Superfamily: Ribulose-phoshate binding barrel Family: NanE-like Phyre2 PDB 5z9y chain B Region: 17 - 261 Aligned: 167 Modelled: 173 Confidence: 99.4% Identity: 25% PDB header:transferase Chain: B: PDB Molecule:thiazole synthase; PDBTitle: crystal structure of mycobacterium tuberculosis thiazole synthase2 (thig) complexed with dxp Phyre2 PDB 3tsm chain B Region: 33 - 258 Aligned: 184 Modelled: 189 Confidence: 99.3% Identity: 15% PDB header:lyase Chain: B: PDB Molecule:indole-3-glycerol phosphate synthase; PDBTitle: crystal structure of indole-3-glycerol phosphate synthase from2 brucella melitensis Phyre2 PDB 1wv2 chain A Region: 108 - 260 Aligned: 151 Modelled: 153 Confidence: 99.3% Identity: 24% Fold: TIM beta/alpha-barrel Superfamily: ThiG-like Family: ThiG-like Phyre2 1 c4firB_ 2 c2zbtB_ 3 c3femB_ 4 c4adsF_ 5 c2nv2U_ 6 c6hyeF_ 7 c6hxgE_ 8 c2yzrB_ 9 d1znna1 10 c1znnF_ 11 d1xm3a_ 12 c3qjaA_ 13 c5zjnB_ 14 c5zknA_ 15 d1yxya1 16 c3q58A_ 17 d1y0ea_ 18 c5z9yB_ 19 c3tsmB_ 20 d1wv2a_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200 201 202 203 204 205 206 207 208 209 210 211 212 213 214 215 216 217 218 219 220 221 222 223 224 225 226 227 228 229 230 231 232 233 234 235 236 237 238 239 240 241 242 243 244 245 246 247 248 249 250 251 252 253 254 255 256 257 258 259 260 261 262 263 264 265 266 267 268 269 270 271 272 273 274 275 276 277 278 279 280 281 282 283 284 285 286 287 288 289 290 291 292 293 294 295 296 297 298 299 300 301 302 303 304 305 306 307 308 309 310 311 312 313 314 315 316 317 318 319 320 321 322 323 324 325 326 327 328 329 330 331 332 333 334 335 336 337 338 339 340 341 342 343 344 345 346 347 348 349 350 351 352 353 354 355 356 357 358 359 360 361 362 363 364 365 366 367 368 369 370 371 372 373 374 375 376 377 378 379 380 381 382 383 384 385 386 387 388 389 390 391 392 393 394 395 396 397 398 399 400 401 402 403 404 405 406 407 408 409 410 411 412 413 414 415 416 417 418 419