1

.

.

.

.

.

.

.

.

10

.

.

.

.

.

.

.

.

.

20

.

.

.

.

.

.

.

.

.

30

.

.

.

.

.

.

.

.

.

40

.

.

.

.

.

.

.

.

.

50

.

.

.

.

.

.

.

.

.

60

Sequence

V

L

R

A

A

P

V

I

N

R

L

T

N

R

P

I

S

R

R

G

V

L

A

G

G

A

A

L

A

A

L

G

V

V

S

A

C

G

E

S

A

P

K

A

P

A

V

E

E

L

R

S

P

L

D

Q

A

R

H

D

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

.

.

.

.

.

.

.

.

.

70

.

.

.

.

.

.

.

.

.

80

.

.

.

.

.

.

.

.

.

90

.

.

.

.

.

.

.

.

.

100

.

.

.

.

.

.

.

.

.

110

.

.

.

.

.

.

.

.

.

120

Sequence

G

A

L

A

A

A

A

A

T

A

I

G

I

P

P

Q

V

A

A

A

L

T

V

V

A

T

Q

R

T

S

H

A

R

A

L

A

T

E

I

A

R

A

A

G

K

L

V

S

A

T

S

E

T

S

S

S

S

P

S

P

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

.

.

.

.

.

.

.

.

.

130

.

.

.

.

.

.

.

.

.

140

.

.

.

.

.

.

.

.

.

150

.

.

.

.

.

.

.

.

.

160

.

.

.

.

.

.

.

.

.

170

.

.

.

.

.

.

.

.

.

180

Sequence

T

D

P

A

A

P

P

P

A

V

S

D

V

I

D

S

L

R

T

S

A

G

E

A

S

R

L

V

A

T

T

S

G

Y

R

A

G

L

L

A

S

I

A

A

S

C

T

A

S

Y

T

V

A

L

V

P

S

G

P

S

Secondary structure

SS confidence

Disorder

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

?

Disorder confidence

.

Sequence

I

Secondary structure

SS confidence

Disorder

?

Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 46%) Alpha helix ( 75%) Beta strand ( 0%)

Rank Aligned region

PDB 3viq chain C Region: 44 - 66 Aligned: 23 Modelled: 23 Confidence: 22.1% Identity: 13% PDB header:recombination activator Chain: C: PDB Molecule:swi5-dependent recombination dna repair protein 1; PDBTitle: crystal structure of swi5-sfr1 complex from fission yeast Phyre2 PDB 4etr chain A Region: 59 - 104 Aligned: 46 Modelled: 46 Confidence: 21.6% Identity: 22% PDB header:unknown function Chain: A: PDB Molecule:putative uncharacterized protein; PDBTitle: x-ray structure of pa2169 from pseudomonas aeruginosa Phyre2 PDB 6fo2 chain R Region: 14 - 36 Aligned: 23 Modelled: 23 Confidence: 10.7% Identity: 26% PDB header:membrane protein Chain: R: PDB Molecule:cytochrome b-c1 complex subunit rieske, mitochondrial; PDBTitle: cryoem structure of bovine cytochrome bc1 with no ligand bound Phyre2 PDB 1xnl chain A Region: 90 - 103 Aligned: 13 Modelled: 14 Confidence: 10.7% Identity: 54% PDB header:viral protein Chain: A: PDB Molecule:membrane protein gp37; PDBTitle: aslv fusion peptide Phyre2 PDB 2fyu chain E Region: 16 - 36 Aligned: 21 Modelled: 21 Confidence: 10.0% Identity: 29% PDB header:oxidoreductase Chain: E: PDB Molecule:ubiquinol-cytochrome c reductase iron-sulfur subunit, PDBTitle: crystal structure of bovine heart mitochondrial bc1 with jg1442 inhibitor Phyre2 PDB 3vep chain X Region: 44 - 62 Aligned: 19 Modelled: 19 Confidence: 10.0% Identity: 32% PDB header:membrane protein/transcription Chain: X: PDB Molecule:uncharacterized protein rv3413c/mt3522; PDBTitle: crystal structure of sigd4 in complex with its negative regulator rsda Phyre2 PDB 3vep chain C Region: 44 - 62 Aligned: 19 Modelled: 19 Confidence: 9.8% Identity: 32% PDB header:membrane protein/transcription Chain: C: PDB Molecule:uncharacterized protein rv3413c/mt3522; PDBTitle: crystal structure of sigd4 in complex with its negative regulator rsda Phyre2 PDB 3no7 chain A Region: 92 - 109 Aligned: 18 Modelled: 18 Confidence: 7.8% Identity: 28% PDB header:dna binding protein Chain: A: PDB Molecule:putative plasmid related protein; PDBTitle: crystal structure of the centromere-binding protein parb from plasmid2 pcxc100 Phyre2 PDB 2fyn chain O Region: 17 - 36 Aligned: 20 Modelled: 20 Confidence: 6.7% Identity: 30% PDB header:oxidoreductase Chain: O: PDB Molecule:ubiquinol-cytochrome c reductase iron-sulfur PDBTitle: crystal structure analysis of the double mutant rhodobacter2 sphaeroides bc1 complex Phyre2 PDB 3he5 chain D Region: 95 - 102 Aligned: 8 Modelled: 8 Confidence: 5.1% Identity: 63% PDB header:de novo protein Chain: D: PDB Molecule:synzip2; PDBTitle: heterospecific coiled-coil pair synzip2:synzip1 Phyre2 1 c3viqC_ 2 c4etrA_ 3 c6fo2R_ 4 c1xnlA_ 5 c2fyuE_ 6 c3vepX_ 7 c3vepC_ 8 c3no7A_ 9 c2fynO_ 10 c3he5D_