1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	T	A	L	N	D	T	E	R	A	V	R	N	W	T	A	G	R	P	H	R	P	A	P	M	R	P	P	R	S	E	E	T	A	S	E	R	P	S	R	Y	Y	P	T	W	L	P	S	R	S	F	I	A	A	V	I	A	I	G	G
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		M	Q	L	L	A	T	M	D	S	T	V	A	I	V	A	L	P	K	I	Q	N	E	L	S	L	S	D	A	G	R	S	W	V	I	T	A	Y	V	L	T	F	G	G	L	M	L	L	G	G	R	L	G	D	T	I	G	R	K	R	T
Secondary structure
SS confidence
Disorder																								?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		F	I	V	G	V	A	L	F	T	I	S	S	V	L	C	A	V	A	W	D	E	A	T	L	V	I	A	R	L	S	Q	G	V	G	S	A	I	A	S	P	T	G	L	A	L	V	A	T	T	F	P	K	G	P	A	R	N	A	A	T
Secondary structure
SS confidence
Disorder																																																		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		A	V	F	A	A	M	T	A	I	G	S	V	M	G	L	V	V	G	G	A	L	T	E	V	S	W	R	W	A	F	L	V	N	V	P	I	G	L	V	M	I	Y	L	A	R	T	A	L	R	E	T	N	K	E	R	M	K	L	D	A
Secondary structure
SS confidence
Disorder																																																					?	?		?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		T	G	A	I	L	A	T	L	A	C	T	A	A	V	F	A	F	S	I	G	P	E	K	G	W	M	S	G	I	T	I	G	S	G	L	V	A	L	A	A	A	V	A	F	V	I	V	E	R	T	A	E	N	P	V	V	P	F	H	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		F	R	D	R	N	R	L	V	T	F	S	A	I	L	L	A	G	G	V	M	F	S	L	T	V	C	I	G	L	Y	V	Q	D	I	L	G	Y	S	A	L	R	A	G	V	G	F	I	P	F	V	I	A	M	G	I	G	L	G	V	S
Secondary structure
SS confidence
Disorder		?	?	?		?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		S	Q	L	V	S	R	F	S	P	R	V	L	T	I	G	G	G	Y	L	L	F	G	A	M	L	Y	G	S	F	F	M	H	R	G	V	P	Y	F	P	N	L	V	M	P	I	V	V	G	G	I	G	I	G	M	A	V	V	P	L	T
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		L	S	A	I	A	G	V	G	F	D	Q	I	G	P	V	S	A	I	A	L	M	L	Q	S	L	G	G	P	L	V	L	A	V	I	Q	A	V	I	T	S	R	T	L	Y	L	G	G	T	T	G	P	V	K	F	M	N	D	V	Q	L
Secondary structure
SS confidence
Disorder						?							?		?																											?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.	.	.	.	.	.	.	.	.	520	.	.	.	.	.	.	.	.	.	530
Sequence		A	A	L	D	H	A	Y	T	Y	G	L	L	W	V	A	G	A	A	I	I	V	G	G	M	A	L	F	I	G	Y	T	P	Q	Q	V	A	H	A	Q	E	V	K	E	A	I	D	A	G	E	L
Secondary structure
SS confidence
Disorder																														?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 20%) Alpha helix ( 71%) Beta strand ( 0%) TM helix ( 54%) (View membrane topology prediction)

Rank Aligned region

PDB 1pw4 chain A Region: 31 - 522 Aligned: 424 Modelled: 425 Confidence: 100.0% Identity: 11% Fold: MFS general substrate transporter Superfamily: MFS general substrate transporter Family: Glycerol-3-phosphate transporter Phyre2 PDB 6e9o chain A Region: 46 - 514 Aligned: 393 Modelled: 395 Confidence: 100.0% Identity: 15% PDB header:membrane protein Chain: A: PDB Molecule:d-galactonate transport; PDBTitle: e. coli d-galactonate:proton symporter mutant e133q in the outward2 substrate-bound form Phyre2 PDB 4zp0 chain A Region: 46 - 507 Aligned: 390 Modelled: 391 Confidence: 100.0% Identity: 17% PDB header:transport protein Chain: A: PDB Molecule:multidrug transporter mdfa; PDBTitle: crystal structure of e. coli multidrug transporter mdfa in complex2 with deoxycholate Phyre2 PDB 4lds chain B Region: 54 - 513 Aligned: 416 Modelled: 416 Confidence: 100.0% Identity: 14% PDB header:transport protein, membrane protein Chain: B: PDB Molecule:bicyclomycin resistance protein tcab; PDBTitle: the inward-facing structure of the glucose transporter from2 staphylococcus epidermidis Phyre2 PDB 4cl5 chain B Region: 42 - 518 Aligned: 449 Modelled: 459 Confidence: 100.0% Identity: 11% PDB header:transport protein Chain: B: PDB Molecule:nitrate transporter 1.1; PDBTitle: crystal structure of the nitrate transporter nrt1.1 from2 arabidopsis thaliana in complex with nitrate. Phyre2 PDB 3wdo chain A Region: 44 - 529 Aligned: 406 Modelled: 413 Confidence: 100.0% Identity: 17% PDB header:transport protein Chain: A: PDB Molecule:mfs transporter; PDBTitle: structure of e. coli yajr transporter Phyre2 PDB 4j05 chain A Region: 52 - 527 Aligned: 409 Modelled: 409 Confidence: 100.0% Identity: 14% PDB header:transport protein Chain: A: PDB Molecule:phosphate transporter; PDBTitle: crystal structure of a eukaryotic phosphate transporter Phyre2 PDB 6h7d chain A Region: 48 - 526 Aligned: 440 Modelled: 440 Confidence: 100.0% Identity: 13% PDB header:membrane protein Chain: A: PDB Molecule:sugar transport protein 10; PDBTitle: crystal structure of a. thaliana sugar transport protein 10 in complex2 with glucose in the outward occluded state Phyre2 PDB 6gs7 chain A Region: 46 - 517 Aligned: 455 Modelled: 458 Confidence: 100.0% Identity: 15% PDB header:membrane protein Chain: A: PDB Molecule:dipeptide and tripeptide permease a; PDBTitle: crystal structure of peptide transporter dtpa-nanobody in glycine2 buffer Phyre2 PDB 4iky chain A Region: 30 - 518 Aligned: 464 Modelled: 464 Confidence: 100.0% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:di-tripeptide abc transporter (permease); PDBTitle: crystal structure of peptide transporter pot (e310q mutant) in complex2 with sulfate Phyre2 PDB 2gfp chain A Region: 55 - 507 Aligned: 372 Modelled: 375 Confidence: 100.0% Identity: 19% PDB header:membrane protein Chain: A: PDB Molecule:multidrug resistance protein d; PDBTitle: structure of the multidrug transporter emrd from2 escherichia coli Phyre2 PDB 4aps chain B Region: 47 - 508 Aligned: 435 Modelled: 437 Confidence: 100.0% Identity: 11% PDB header:transport protein Chain: B: PDB Molecule:di-or tripeptide h+ symporter; PDBTitle: crystal structure of a pot family peptide transporter in an inward2 open conformation. Phyre2 PDB 4gbz chain A Region: 46 - 522 Aligned: 459 Modelled: 459 Confidence: 100.0% Identity: 13% PDB header:transport protein Chain: A: PDB Molecule:d-xylose-proton symporter; PDBTitle: the structure of the mfs (major facilitator superfamily) proton:xylose2 symporter xyle bound to d-glucose Phyre2 PDB 5c65 chain A Region: 46 - 527 Aligned: 440 Modelled: 440 Confidence: 100.0% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:solute carrier family 2, facilitated glucose transporter PDBTitle: structure of the human glucose transporter glut3 / slc2a3 Phyre2 PDB 6exs chain A Region: 34 - 514 Aligned: 456 Modelled: 456 Confidence: 100.0% Identity: 10% PDB header:membrane protein Chain: A: PDB Molecule:peptide abc transporter permease; PDBTitle: crystal structure of a pot family transporter in complex with2 thioalcohol conjugated peptide. Phyre2 PDB 6g9x chain B Region: 52 - 514 Aligned: 368 Modelled: 377 Confidence: 100.0% Identity: 15% PDB header:membrane protein Chain: B: PDB Molecule:major facilitator superfamily mfs_1; PDBTitle: crystal structure of a mfs transporter at 2.54 angstroem resolution Phyre2 PDB 2xut chain C Region: 56 - 504 Aligned: 436 Modelled: 436 Confidence: 100.0% Identity: 11% PDB header:transport protein Chain: C: PDB Molecule:proton/peptide symporter family protein; PDBTitle: crystal structure of a proton dependent oligopeptide (pot) family2 transporter. Phyre2 PDB 4w6v chain A Region: 35 - 514 Aligned: 458 Modelled: 457 Confidence: 100.0% Identity: 12% PDB header:transport protein Chain: A: PDB Molecule:di-/tripeptide transporter; PDBTitle: crystal structure of a peptide transporter from yersinia2 enterocolitica at 3 a resolution Phyre2 PDB 6ei3 chain A Region: 48 - 522 Aligned: 462 Modelled: 462 Confidence: 100.0% Identity: 12% PDB header:membrane protein Chain: A: PDB Molecule:proton-dependent oligopeptide transporter family protein; PDBTitle: crystal structure of auto inhibited pot family peptide transporter Phyre2 PDB 4ybq chain B Region: 41 - 530 Aligned: 453 Modelled: 453 Confidence: 100.0% Identity: 9% PDB header:transport protein/immune system Chain: B: PDB Molecule:solute carrier family 2, facilitated glucose transporter PDBTitle: rat glut5 with fv in the outward-open form Phyre2 1 d1pw4a_ 2 c6e9oA_ 3 c4zp0A_ 4 c4ldsB_ 5 c4cl5B_ 6 c3wdoA_ 7 c4j05A_ 8 c6h7dA_ 9 c6gs7A_ 10 c4ikyA_ 11 c2gfpA_ 12 c4apsB_ 13 c4gbzA_ 14 c5c65A_ 15 c6exsA_ 16 c6g9xB_ 17 c2xutC_ 18 c4w6vA_ 19 c6ei3A_ 20 c4ybqB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48