1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	I	T	T	T	S	Q	E	I	E	L	A	P	T	R	L	P	G	S	Q	N	A	A	R	L	F	V	A	Q	T	L	L	Q	T	N	R	L	L	T	R	W	A	R	D	Y	I	T	V	I	G	A	I	V	L	P	I	L	F	M	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		V	L	N	I	V	L	G	N	L	A	Y	V	V	T	H	D	S	G	L	Y	S	I	V	P	L	I	A	L	G	A	A	I	T	G	S	T	F	V	A	I	D	L	M	R	E	R	S	F	G	L	L	A	R	L	W	V	L	P	V	H
Secondary structure
SS confidence
Disorder							?	?	?	?	?	?	?	?	?																																											?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		R	A	S	G	L	I	S	R	I	L	A	N	A	I	R	T	L	V	T	T	L	V	M	L	G	T	G	V	V	L	G	F	R	F	R	Q	G	L	I	P	S	L	M	W	I	S	V	P	V	I	L	G	I	A	I	A	A	M	V	T
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		T	V	A	L	Y	T	A	Q	T	V	V	V	E	G	V	E	L	V	Q	A	I	A	I	F	F	S	T	G	L	V	P	L	N	S	Y	P	G	W	I	Q	P	F	V	A	H	Q	P	V	S	Y	A	I	A	A	M	R	G	F	A	M
Secondary structure
SS confidence
Disorder						?	?	?	?																			?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.
Sequence		G	G	P	V	L	S	P	M	I	G	M	L	V	W	T	A	G	I	C	V	V	C	A	V	P	L	A	I	G	Y	R	R	A	S	T	H
Secondary structure
SS confidence
Disorder																																			?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 16%) Alpha helix ( 78%) Beta strand ( 0%) TM helix ( 53%) (View membrane topology prediction)

Rank Aligned region

PDB 6an7 chain C Region: 28 - 276 Aligned: 242 Modelled: 249 Confidence: 100.0% Identity: 11% PDB header:transport protein Chain: C: PDB Molecule:transport permease protein; PDBTitle: crystal structure of o-antigen polysaccharide abc-transporter Phyre2 PDB 5njg chain B Region: 25 - 276 Aligned: 250 Modelled: 252 Confidence: 100.0% Identity: 12% PDB header:transport protein Chain: B: PDB Molecule:atp-binding cassette sub-family g member 2; PDBTitle: structure of an abc transporter: part of the structure that could be2 built de novo Phyre2 PDB 6an7 chain D Region: 28 - 276 Aligned: 240 Modelled: 249 Confidence: 100.0% Identity: 11% PDB header:transport protein Chain: D: PDB Molecule:transport permease protein; PDBTitle: crystal structure of o-antigen polysaccharide abc-transporter Phyre2 PDB 5do7 chain A Region: 10 - 274 Aligned: 264 Modelled: 265 Confidence: 100.0% Identity: 9% PDB header:transport protein Chain: A: PDB Molecule:atp-binding cassette sub-family g member 5; PDBTitle: crystal structure of the human sterol transporter abcg5/abcg8 Phyre2 PDB 5do7 chain B Region: 21 - 272 Aligned: 251 Modelled: 252 Confidence: 100.0% Identity: 12% PDB header:transport protein Chain: B: PDB Molecule:atp-binding cassette sub-family g member 8; PDBTitle: crystal structure of the human sterol transporter abcg5/abcg8 Phyre2 PDB 5nj3 chain B Region: 21 - 276 Aligned: 254 Modelled: 256 Confidence: 100.0% Identity: 11% PDB header:transport protein Chain: B: PDB Molecule:atp-binding cassette sub-family g member 2; PDBTitle: structure of an abc transporter: complete structure Phyre2 PDB 5xjy chain A Region: 77 - 267 Aligned: 190 Modelled: 191 Confidence: 98.6% Identity: 10% PDB header:transport protein Chain: A: PDB Molecule:atp-binding cassette sub-family a member 1; PDBTitle: cryo-em structure of human abca1 Phyre2 PDB 6adq chain I Region: 249 - 276 Aligned: 28 Modelled: 28 Confidence: 63.8% Identity: 21% PDB header:electron transport Chain: I: PDB Molecule:cytochrome c oxidase subunit ctaj; PDBTitle: respiratory complex ciii2civ2sod2 from mycobacterium smegmatis Phyre2 PDB 6hwh chain R Region: 259 - 276 Aligned: 18 Modelled: 18 Confidence: 56.2% Identity: 33% PDB header:electron transport Chain: R: PDB Molecule:msmeg_4693; PDBTitle: structure of a functional obligate respiratory supercomplex from2 mycobacterium smegmatis Phyre2 PDB 1ifl chain A Region: 229 - 272 Aligned: 40 Modelled: 44 Confidence: 23.0% Identity: 23% PDB header:virus Chain: A: PDB Molecule:inovirus; PDBTitle: molecular models and structural comparisons of native and2 mutant class i filamentous bacteriophages ff (fd, f1, m13),3 if1 and ike Phyre2 PDB 6d6t chain E Region: 43 - 98 Aligned: 56 Modelled: 56 Confidence: 7.8% Identity: 14% PDB header:transport protein Chain: E: PDB Molecule:human gaba-a receptor subunit gamma-2; PDBTitle: human gaba-a receptor alpha1-beta2-gamma2 subtype in complex with gaba2 and flumazenil, conformation b Phyre2 PDB 1fft chain B domain 2 Region: 225 - 276 Aligned: 46 Modelled: 52 Confidence: 7.7% Identity: 17% Fold: Transmembrane helix hairpin Superfamily: Cytochrome c oxidase subunit II-like, transmembrane region Family: Cytochrome c oxidase subunit II-like, transmembrane region Phyre2 PDB 2lly chain A Region: 43 - 100 Aligned: 55 Modelled: 58 Confidence: 6.6% Identity: 11% PDB header:transport protein Chain: A: PDB Molecule:neuronal acetylcholine receptor subunit alpha-4; PDBTitle: nmr structures of the transmembrane domains of the nachr a4 subunit Phyre2 PDB 2k58 chain B Region: 42 - 75 Aligned: 34 Modelled: 34 Confidence: 6.3% Identity: 15% PDB header:transport protein Chain: B: PDB Molecule:neuronal acetylcholine receptor subunit beta-2; PDBTitle: nmr structures of the first transmembrane domain of the2 neuronal acetylcholine receptor beta 2 subunit Phyre2 PDB 2maw chain A Region: 43 - 96 Aligned: 54 Modelled: 54 Confidence: 5.7% Identity: 9% PDB header:membrane protein Chain: A: PDB Molecule:neuronal acetylcholine receptor subunit alpha-7; PDBTitle: nmr structures of the alpha7 nachr transmembrane domain. Phyre2 PDB 4hkr chain B Region: 240 - 276 Aligned: 37 Modelled: 37 Confidence: 5.5% Identity: 11% PDB header:transport protein Chain: B: PDB Molecule:calcium release-activated calcium channel protein 1; PDBTitle: calcium release-activated calcium (crac) channel orai Phyre2 PDB 4hkr chain A Region: 240 - 276 Aligned: 37 Modelled: 37 Confidence: 5.2% Identity: 11% PDB header:transport protein Chain: A: PDB Molecule:calcium release-activated calcium channel protein 1; PDBTitle: calcium release-activated calcium (crac) channel orai Phyre2 PDB 4cdi chain C Region: 45 - 67 Aligned: 23 Modelled: 23 Confidence: 5.1% Identity: 22% PDB header:membrane protein Chain: C: PDB Molecule:predicted protein; PDBTitle: crystal structure of acrb-acrz complex Phyre2 PDB 2bbj chain B Region: 254 - 273 Aligned: 20 Modelled: 20 Confidence: 5.1% Identity: 15% PDB header:metal transport/membrane protein Chain: B: PDB Molecule:divalent cation transport-related protein; PDBTitle: crystal structure of the cora mg2+ transporter Phyre2 PDB 2jwa chain A Region: 44 - 67 Aligned: 24 Modelled: 24 Confidence: 5.0% Identity: 42% PDB header:transferase Chain: A: PDB Molecule:receptor tyrosine-protein kinase erbb-2; PDBTitle: erbb2 transmembrane segment dimer spatial structure Phyre2 1 c6an7C_ 2 c5njgB_ 3 c6an7D_ 4 c5do7A_ 5 c5do7B_ 6 c5nj3B_ 7 c5xjyA_ 8 c6adqI_ 9 c6hwhR_ 10 c1iflA_ 11 c6d6tE_ 12 d1fftb2 13 c2llyA_ 14 c2k58B_ 15 c2mawA_ 16 c4hkrB_ 17 c4hkrA_ 18 c4cdiC_ 19 c2bbjB_ 20 c2jwaA_