1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	A	D	A	S	V	V	A	R	L	R	S	W	A	L	A	V	W	H	F	V	S	N	A	P	L	T	Y	A	W	L	V	V	L	V	I	T	T	I	I	Q	N	N	L	T	G	S	Q	L	H	F	V	L	L	H	R	S	T	N	I
Secondary structure
SS confidence
Disorder		?	?	?					?	?	?	?	?	?	?																												?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	E	L	G	R	D	P	L	E	V	L	F	S	S	L	L	W	I	D	G	R	N	L	E	P	Y	L	L	L	F	T	L	F	L	A	P	A	E	H	W	L	G	H	L	R	W	L	T	V	G	L	T	A	H	I	G	A	T	Y	L
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		S	E	G	L	L	Y	L	A	I	Q	H	R	D	A	S	E	R	M	V	H	A	R	D	I	G	V	S	Y	F	L	V	G	V	M	A	V	L	T	Y	H	I	A	K	P	W	R	W	G	Y	L	G	V	L	L	V	I	F	G	F	P
Secondary structure
SS confidence
Disorder																																								?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.
Sequence		L	I	A	M	D	K	A	E	L	D	F	T	A	V	G	H	F	A	S	I	L	I	G	L	L	F	Y	P	M	A	R	E	R	D	G	R	L	W	N	P	A	R	I	K	S	L	L	H	R	R	G	T	R	G	R	R	A
Secondary structure
SS confidence
Disorder				?			?																							?		?	?	?	?	?	?	?	?	?		?										?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 14%) Alpha helix ( 78%) Beta strand ( 0%) TM helix ( 43%) (View membrane topology prediction)

Rank Aligned region

PDB 3b45 chain A domain 1 Region: 22 - 210 Aligned: 172 Modelled: 175 Confidence: 99.9% Identity: 16% Fold: Rhomboid-like Superfamily: Rhomboid-like Family: Rhomboid-like Phyre2 PDB 2nr9 chain A domain 1 Region: 21 - 214 Aligned: 177 Modelled: 180 Confidence: 99.9% Identity: 11% Fold: Rhomboid-like Superfamily: Rhomboid-like Family: Rhomboid-like Phyre2 PDB 2n2a chain A Region: 195 - 234 Aligned: 36 Modelled: 40 Confidence: 6.1% Identity: 14% PDB header:membrane protein Chain: A: PDB Molecule:receptor tyrosine-protein kinase erbb-2; PDBTitle: spatial structure of her2/erbb2 dimeric transmembrane domain in the2 presence of cytoplasmic juxtamembrane domains Phyre2 PDB 2mic chain A Region: 197 - 216 Aligned: 20 Modelled: 20 Confidence: 5.4% Identity: 20% PDB header:membrane protein Chain: A: PDB Molecule:tumor necrosis factor receptor superfamily member 16; PDBTitle: nmr structure of p75 transmembrane domain in dpc micelles Phyre2 1 d3b45a1 2 d2nr9a1 3 c2n2aA_ 4 c2micA_