1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		M	A	D	R	I	E	L	R	G	L	T	V	H	G	R	H	G	V	Y	D	H	E	R	V	A	G	Q	R	F	V	I	D	V	T	V	W	I	D	L	A	E	A	A	N	S	D	D	L	A	D	T	Y	D	Y	V	R	L	A	S	R
Secondary structure
SS confidence
Disorder		?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		A	A	E	I	V	A	G	P	P	R	K	L	I	E	T	V	G	A	E	I	A	D	H	V	M	D	D	Q	R	V	H	A	V	E	V	A	V	H	K	P	Q	A	P	I	P	Q	T	F	D	D	V	A	V	V	I	R	R	S	R	R
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.
Sequence		G	G	R	G	W	V	V	P	A	G	G	A	V
Secondary structure
SS confidence
Disorder			?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 11%) Alpha helix ( 29%) Beta strand ( 38%)

Rank Aligned region

PDB 1dhn chain A Region: 1 - 120 Aligned: 120 Modelled: 120 Confidence: 100.0% Identity: 33% Fold: T-fold Superfamily: Tetrahydrobiopterin biosynthesis enzymes-like Family: DHN aldolase/epimerase Phyre2 PDB 1nbu chain A Region: 2 - 119 Aligned: 118 Modelled: 118 Confidence: 100.0% Identity: 100% Fold: T-fold Superfamily: Tetrahydrobiopterin biosynthesis enzymes-like Family: DHN aldolase/epimerase Phyre2 PDB 5f3m chain A Region: 2 - 119 Aligned: 118 Modelled: 117 Confidence: 100.0% Identity: 35% PDB header:isomerase Chain: A: PDB Molecule:7,8-dihydroneopterin aldolase; PDBTitle: crystal structure of dihydroneopterin aldolase from bacillus anthracis2 complexed with l-neopterin at 1.5 angstroms resolution . Phyre2 PDB 1sql chain N Region: 2 - 120 Aligned: 119 Modelled: 119 Confidence: 100.0% Identity: 42% PDB header:lyase Chain: N: PDB Molecule:dihydroneopterin aldolase; PDBTitle: crystal structure of 7,8-dihydroneopterin aldolase in2 complex with guanine Phyre2 PDB 1sql chain A Region: 2 - 119 Aligned: 118 Modelled: 118 Confidence: 100.0% Identity: 42% Fold: T-fold Superfamily: Tetrahydrobiopterin biosynthesis enzymes-like Family: DHN aldolase/epimerase Phyre2 PDB 2o90 chain A Region: 2 - 117 Aligned: 114 Modelled: 116 Confidence: 100.0% Identity: 32% PDB header:lyase Chain: A: PDB Molecule:dihydroneopterin aldolase; PDBTitle: atomic resolution crystal structure of e.coli dihydroneopterin2 aldolase in complex with neopterin Phyre2 PDB 1b9l chain A Region: 3 - 119 Aligned: 115 Modelled: 117 Confidence: 100.0% Identity: 23% Fold: T-fold Superfamily: Tetrahydrobiopterin biosynthesis enzymes-like Family: DHN aldolase/epimerase Phyre2 PDB 2cg8 chain B Region: 2 - 120 Aligned: 115 Modelled: 115 Confidence: 100.0% Identity: 24% PDB header:lyase/transferase Chain: B: PDB Molecule:dihydroneopterin aldolase 6-hydroxymethyl-7,8- PDBTitle: the bifunctional dihydroneopterin aldolase 6-hydroxymethyl-2 7,8-dihydropterin synthase from streptococcus pneumoniae Phyre2 PDB 3v9o chain A Region: 3 - 120 Aligned: 111 Modelled: 113 Confidence: 100.0% Identity: 27% PDB header:lyase Chain: A: PDB Molecule:dihydroneopterin aldolase; PDBTitle: crystal structure of dihydroneopterin aldolase (bth_i0291) from2 burkholderia thailendensis bound to guanine. Phyre2 PDB 4aey chain A Region: 2 - 117 Aligned: 104 Modelled: 116 Confidence: 100.0% Identity: 25% PDB header:isomerase Chain: A: PDB Molecule:d-erythro-7,8-dihydroneopterin triphosphate epimerase; PDBTitle: crystal structure of folx from pseudomonas aeruginosa Phyre2 PDB 2iba chain A domain 1 Region: 29 - 98 Aligned: 70 Modelled: 70 Confidence: 90.9% Identity: 13% Fold: T-fold Superfamily: Tetrahydrobiopterin biosynthesis enzymes-like Family: Urate oxidase (uricase) Phyre2 PDB 5m98 chain H Region: 29 - 98 Aligned: 70 Modelled: 70 Confidence: 89.3% Identity: 16% PDB header:oxidoreductase Chain: H: PDB Molecule:uricase; PDBTitle: crystal structure of urate oxidase from zebrafish Phyre2 PDB 2yzc chain A domain 1 Region: 29 - 98 Aligned: 69 Modelled: 70 Confidence: 87.6% Identity: 12% Fold: T-fold Superfamily: Tetrahydrobiopterin biosynthesis enzymes-like Family: Urate oxidase (uricase) Phyre2 PDB 1j2g chain A domain 1 Region: 29 - 98 Aligned: 70 Modelled: 70 Confidence: 86.7% Identity: 10% Fold: T-fold Superfamily: Tetrahydrobiopterin biosynthesis enzymes-like Family: Urate oxidase (uricase) Phyre2 PDB 1r56 chain H Region: 29 - 98 Aligned: 70 Modelled: 70 Confidence: 83.7% Identity: 13% PDB header:oxidoreductase Chain: H: PDB Molecule:uricase; PDBTitle: uncomplexed urate oxidase from aspergillus flavus Phyre2 PDB 2yzb chain A Region: 29 - 98 Aligned: 69 Modelled: 70 Confidence: 82.4% Identity: 12% PDB header:oxidoreductase Chain: A: PDB Molecule:uricase; PDBTitle: crystal structure of uricase from arthrobacter globiformis2 in complex with uric acid (substrate) Phyre2 PDB 1j2g chain C Region: 29 - 98 Aligned: 70 Modelled: 70 Confidence: 76.1% Identity: 10% PDB header:oxidoreductase Chain: C: PDB Molecule:uricase; PDBTitle: crystal structure of urate oxidase from bacillus sp. tb-90 co-2 crystallized with 8-azaxanthine Phyre2 PDB 4r99 chain B Region: 29 - 98 Aligned: 70 Modelled: 70 Confidence: 74.8% Identity: 10% PDB header:hydrolase Chain: B: PDB Molecule:uricase; PDBTitle: crystal structure of a uricase from bacillus fastidious Phyre2 PDB 2dj6 chain B Region: 1 - 98 Aligned: 90 Modelled: 98 Confidence: 62.9% Identity: 23% PDB header:lyase Chain: B: PDB Molecule:hypothetical protein ph0634; PDBTitle: crystal structure of 6-pyruvoyl tetrahydrobiopterin synthase from2 pyrococcus horikoshii ot3 Phyre2 PDB 3d2o chain B Region: 3 - 98 Aligned: 82 Modelled: 96 Confidence: 58.0% Identity: 15% PDB header:hydrolase, biosynthetic protein Chain: B: PDB Molecule:upf0343 protein ngo0387; PDBTitle: crystal structure of manganese-metallated gtp cyclohydrolase type ib Phyre2 1 d1dhna_ 2 d1nbua_ 3 c5f3mA_ 4 c1sqlN_ 5 d1sqla_ 6 c2o90A_ 7 d1b9la_ 8 c2cg8B_ 9 c3v9oA_ 10 c4aeyA_ 11 d2ibaa1 12 c5m98H_ 13 d2yzca1 14 d1j2ga1 15 c1r56H_ 16 c2yzbA_ 17 c1j2gC_ 18 c4r99B_ 19 c2dj6B_ 20 c3d2oB_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51