1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	T	T	D	E	D	L	I	R	A	A	L	A	V	A	A	T	A	G	P	R	D	V	P	V	G	A	V	V	V	G	A	D	G	T	E	L	A	R	A	V	N	A	R	E	A	L	G	D	P	T	A	H	A	E	I	L	A	M	R
Secondary structure
SS confidence
Disorder		?	?	?														?	?	?	?	?	?																								?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	A	A	G	V	L	G	D	G	W	R	L	E	G	T	T	L	A	V	T	V	E	P	C	T	M	C	A	G	A	L	V	L	A	R	V	A	R	L	V	F	G	A	W	E	P	K	T	G	A	V	G	S	L	W	D	V	V	R	D
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.
Sequence		R	R	L	N	H	R	P	E	V	R	G	G	V	L	A	R	E	C	A	A	P	L	E	A	F	F	A	R	Q	R	L	G
Secondary structure
SS confidence
Disorder																															?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 9%) Alpha helix ( 41%) Beta strand ( 18%) TM helix ( 11%) (View membrane topology prediction)

Rank Aligned region

PDB 2nx8 chain A Region: 1 - 150 Aligned: 148 Modelled: 150 Confidence: 100.0% Identity: 40% PDB header:hydrolase Chain: A: PDB Molecule:trna-specific adenosine deaminase; PDBTitle: the crystal structure of the trna-specific adenosine deaminase from2 streptococcus pyogenes Phyre2 PDB 2b3j chain A domain 1 Region: 1 - 151 Aligned: 149 Modelled: 151 Confidence: 100.0% Identity: 46% Fold: Cytidine deaminase-like Superfamily: Cytidine deaminase-like Family: Deoxycytidylate deaminase-like Phyre2 PDB 1z3a chain A domain 1 Region: 3 - 151 Aligned: 147 Modelled: 149 Confidence: 100.0% Identity: 48% Fold: Cytidine deaminase-like Superfamily: Cytidine deaminase-like Family: Deoxycytidylate deaminase-like Phyre2 PDB 3ocq chain A Region: 3 - 147 Aligned: 143 Modelled: 145 Confidence: 100.0% Identity: 50% PDB header:hydrolase Chain: A: PDB Molecule:putative cytosine/adenosine deaminase; PDBTitle: crystal structure of trna-specific adenosine deaminase from salmonella2 enterica Phyre2 PDB 1wwr chain A domain 1 Region: 3 - 152 Aligned: 147 Modelled: 150 Confidence: 100.0% Identity: 40% Fold: Cytidine deaminase-like Superfamily: Cytidine deaminase-like Family: Deoxycytidylate deaminase-like Phyre2 PDB 3dh1 chain D Region: 1 - 148 Aligned: 147 Modelled: 148 Confidence: 100.0% Identity: 27% PDB header:hydrolase Chain: D: PDB Molecule:trna-specific adenosine deaminase 2; PDBTitle: crystal structure of human trna-specific adenosine-34 deaminase2 subunit adat2 Phyre2 PDB 2g84 chain A domain 1 Region: 1 - 151 Aligned: 151 Modelled: 151 Confidence: 100.0% Identity: 26% Fold: Cytidine deaminase-like Superfamily: Cytidine deaminase-like Family: Deoxycytidylate deaminase-like Phyre2 PDB 1p6o chain A Region: 2 - 150 Aligned: 139 Modelled: 149 Confidence: 100.0% Identity: 29% Fold: Cytidine deaminase-like Superfamily: Cytidine deaminase-like Family: Deoxycytidylate deaminase-like Phyre2 PDB 5xkr chain A Region: 2 - 150 Aligned: 147 Modelled: 147 Confidence: 100.0% Identity: 27% PDB header:hydrolase Chain: A: PDB Molecule:cmp/dcmp deaminase, zinc-binding protein; PDBTitle: crystal structure of msmeg3575 in complex with benzoguanamine Phyre2 PDB 2a8n chain A domain 1 Region: 2 - 132 Aligned: 129 Modelled: 131 Confidence: 100.0% Identity: 44% Fold: Cytidine deaminase-like Superfamily: Cytidine deaminase-like Family: Deoxycytidylate deaminase-like Phyre2 PDB 2b3z chain A domain 2 Region: 4 - 152 Aligned: 134 Modelled: 149 Confidence: 100.0% Identity: 31% Fold: Cytidine deaminase-like Superfamily: Cytidine deaminase-like Family: Deoxycytidylate deaminase-like Phyre2 PDB 2d5n chain B Region: 4 - 152 Aligned: 134 Modelled: 145 Confidence: 100.0% Identity: 32% PDB header:hydrolase, oxidoreductase Chain: B: PDB Molecule:riboflavin biosynthesis protein ribd; PDBTitle: crystal structure of a bifunctional deaminase and reductase2 involved in riboflavin biosynthesis Phyre2 PDB 3zpg chain A Region: 1 - 151 Aligned: 136 Modelled: 150 Confidence: 100.0% Identity: 28% PDB header:hydrolase Chain: A: PDB Molecule:ribd; PDBTitle: acinetobacter baumannii ribd, form 2 Phyre2 PDB 2o7p chain A Region: 3 - 152 Aligned: 134 Modelled: 150 Confidence: 100.0% Identity: 33% PDB header:hydrolase, oxidoreductase Chain: A: PDB Molecule:riboflavin biosynthesis protein ribd; PDBTitle: the crystal structure of ribd from escherichia coli in complex with2 the oxidised nadp+ cofactor in the active site of the reductase3 domain Phyre2 PDB 2hxv chain A Region: 3 - 152 Aligned: 137 Modelled: 146 Confidence: 100.0% Identity: 31% PDB header:biosynthetic protein Chain: A: PDB Molecule:diaminohydroxyphosphoribosylaminopyrimidine deaminase/ 5- PDBTitle: crystal structure of a diaminohydroxyphosphoribosylaminopyrimidine2 deaminase/ 5-amino-6-(5-phosphoribosylamino)uracil reductase (tm1828)3 from thermotoga maritima at 1.80 a resolution Phyre2 PDB 2hxv chain A domain 2 Region: 4 - 152 Aligned: 142 Modelled: 149 Confidence: 100.0% Identity: 21% Fold: Cytidine deaminase-like Superfamily: Cytidine deaminase-like Family: Deoxycytidylate deaminase-like Phyre2 PDB 1wkq chain A Region: 3 - 150 Aligned: 146 Modelled: 148 Confidence: 100.0% Identity: 30% Fold: Cytidine deaminase-like Superfamily: Cytidine deaminase-like Family: Deoxycytidylate deaminase-like Phyre2 PDB 2w4l chain C Region: 1 - 146 Aligned: 131 Modelled: 146 Confidence: 100.0% Identity: 18% PDB header:hydrolase Chain: C: PDB Molecule:deoxycytidylate deaminase; PDBTitle: human dcmp deaminase Phyre2 PDB 5jfy chain C Region: 1 - 112 Aligned: 110 Modelled: 112 Confidence: 100.0% Identity: 35% PDB header:hydrolase Chain: C: PDB Molecule:deoxycytidine deaminase; PDBTitle: crystal structure of a plant cytidine deaminase Phyre2 PDB 2hvw chain C Region: 1 - 131 Aligned: 120 Modelled: 131 Confidence: 100.0% Identity: 23% PDB header:hydrolase Chain: C: PDB Molecule:deoxycytidylate deaminase; PDBTitle: crystal structure of dcmp deaminase from streptococcus mutans Phyre2 1 c2nx8A_ 2 d2b3ja1 3 d1z3aa1 4 c3ocqA_ 5 d1wwra1 6 c3dh1D_ 7 d2g84a1 8 d1p6oa_ 9 c5xkrA_ 10 d2a8na1 11 d2b3za2 12 c2d5nB_ 13 c3zpgA_ 14 c2o7pA_ 15 c2hxvA_ 16 d2hxva2 17 d1wkqa_ 18 c2w4lC_ 19 c5jfyC_ 20 c2hvwC_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99