1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		V	R	K	R	M	V	I	G	L	S	T	G	S	D	D	D	D	V	E	V	I	G	G	V	D	P	R	L	I	A	V	Q	E	N	D	S	D	E	S	S	L	T	D	L	V	E	Q	P	A	K	V	M	R	I	G	T	M	I	K	Q
Secondary structure
SS confidence
Disorder		?	?	?	?																											?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		L	L	E	E	V	R	A	A	P	L	D	E	A	S	R	N	R	L	R	D	I	H	A	T	S	I	R	E	L	E	D	G	L	A	P	E	L	R	E	E	L	D	R	L	T	L	P	F	N	E	D	A	V	P	S	D	A	E	L	R
Secondary structure
SS confidence
Disorder								?	?	?	?	?																																				?			?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.
Sequence		I	A	Q	A	Q	L	V	G	W	L	E	G	L	F	H	G	I	Q	T	A	L	F	A	Q	Q	M	A	A	R	A	Q	L	Q	Q	M	R	Q	G	A	L	P	P	G	V	G	K	S	G	Q	H	G	H	G	T	G	Q	Y	L
Secondary structure
SS confidence
Disorder																																				?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 28%) Alpha helix ( 57%) Beta strand ( 6%)

Rank Aligned region

PDB 5iet chain A Region: 40 - 150 Aligned: 111 Modelled: 111 Confidence: 100.0% Identity: 97% PDB header:gene regulation Chain: A: PDB Molecule:bacterial proteasome activator; PDBTitle: crystal structure of mycobacterium tuberculosis atp-independent2 proteasome activator Phyre2 PDB 2lse chain A Region: 58 - 102 Aligned: 44 Modelled: 45 Confidence: 69.8% Identity: 32% PDB header:de novo protein Chain: A: PDB Molecule:four helix bundle protein; PDBTitle: solution nmr structure of de novo designed four helix bundle protein,2 northeast structural genomics consortium (nesg) target or188 Phyre2 PDB 2vee chain C Region: 58 - 136 Aligned: 79 Modelled: 79 Confidence: 36.9% Identity: 16% PDB header:transport protein Chain: C: PDB Molecule:protoglobin; PDBTitle: structure of protoglobin from methanosarcina acetivorans2 c2a Phyre2 PDB 2bmo chain B domain 1 Region: 93 - 134 Aligned: 35 Modelled: 42 Confidence: 31.8% Identity: 31% Fold: Cystatin-like Superfamily: NTF2-like Family: Ring hydroxylating beta subunit Phyre2 PDB 2l6f chain A Region: 54 - 117 Aligned: 62 Modelled: 64 Confidence: 28.6% Identity: 27% PDB header:transferase,cell adhesion Chain: A: PDB Molecule:focal adhesion kinase 1, linker1, paxillin, linker2, PDBTitle: nmr solution structure of fat domain of fak complexed with ld2 and ld42 motifs of paxillin Phyre2 PDB 5ohe chain A Region: 61 - 136 Aligned: 74 Modelled: 76 Confidence: 24.3% Identity: 16% PDB header:transferase Chain: A: PDB Molecule:globin-coupled histidine kinase; PDBTitle: globin sensor domain of afgchk (feiii form) in complex with cyanide Phyre2 PDB 2gjx chain A domain 2 Region: 132 - 139 Aligned: 8 Modelled: 8 Confidence: 21.1% Identity: 38% Fold: Zincin-like Superfamily: beta-N-acetylhexosaminidase-like domain Family: beta-N-acetylhexosaminidase domain Phyre2 PDB 1qba chain A domain 4 Region: 131 - 139 Aligned: 9 Modelled: 9 Confidence: 17.8% Identity: 44% Fold: Zincin-like Superfamily: beta-N-acetylhexosaminidase-like domain Family: beta-N-acetylhexosaminidase domain Phyre2 PDB 2csb chain A domain 1 Region: 90 - 101 Aligned: 12 Modelled: 12 Confidence: 17.7% Identity: 50% Fold: SAM domain-like Superfamily: RuvA domain 2-like Family: Topoisomerase V repeat domain Phyre2 PDB 2cbi chain A domain 3 Region: 131 - 141 Aligned: 11 Modelled: 11 Confidence: 15.3% Identity: 45% Fold: Zincin-like Superfamily: beta-N-acetylhexosaminidase-like domain Family: Hyaluronidase N-terminal domain-like Phyre2 PDB 4tzo chain C Region: 125 - 138 Aligned: 14 Modelled: 14 Confidence: 14.6% Identity: 14% PDB header:peptide binding protein Chain: C: PDB Molecule:protein htp-1; PDBTitle: structure of c. elegans htp-1 bound to him-3 closure motif Phyre2 PDB 1m98 chain A domain 1 Region: 112 - 152 Aligned: 33 Modelled: 41 Confidence: 12.8% Identity: 33% Fold: Orange carotenoid protein, N-terminal domain Superfamily: Orange carotenoid protein, N-terminal domain Family: Orange carotenoid protein, N-terminal domain Phyre2 PDB 1now chain A domain 2 Region: 132 - 139 Aligned: 8 Modelled: 8 Confidence: 12.6% Identity: 38% Fold: Zincin-like Superfamily: beta-N-acetylhexosaminidase-like domain Family: beta-N-acetylhexosaminidase domain Phyre2 PDB 2aq0 chain A domain 1 Region: 78 - 118 Aligned: 38 Modelled: 41 Confidence: 12.2% Identity: 16% Fold: SAM domain-like Superfamily: RuvA domain 2-like Family: Hef domain-like Phyre2 PDB 4xy3 chain A Region: 91 - 151 Aligned: 54 Modelled: 61 Confidence: 12.1% Identity: 20% PDB header:protein transport Chain: A: PDB Molecule:esx-1 secretion-associated protein espb; PDBTitle: structure of esx-1 secreted protein espb Phyre2 PDB 2gbx chain F Region: 113 - 134 Aligned: 22 Modelled: 22 Confidence: 10.5% Identity: 23% PDB header:oxidoreductase Chain: F: PDB Molecule:biphenyl 2,3-dioxygenase beta subunit; PDBTitle: crystal structure of biphenyl 2,3-dioxygenase from sphingomonas2 yanoikuyae b1 bound to biphenyl Phyre2 PDB 1jak chain A domain 2 Region: 132 - 139 Aligned: 8 Modelled: 8 Confidence: 10.1% Identity: 88% Fold: Zincin-like Superfamily: beta-N-acetylhexosaminidase-like domain Family: beta-N-acetylhexosaminidase domain Phyre2 PDB 1j9i chain A Region: 74 - 130 Aligned: 47 Modelled: 57 Confidence: 9.3% Identity: 17% Fold: Putative DNA-binding domain Superfamily: Putative DNA-binding domain Family: Terminase gpNU1 subunit domain Phyre2 PDB 1o8t chain A Region: 109 - 131 Aligned: 23 Modelled: 23 Confidence: 9.3% Identity: 26% PDB header:lipid transport Chain: A: PDB Molecule:apolipoprotein c-ii; PDBTitle: global structure and dynamics of human apolipoprotein cii2 in complex with micelles: evidence for increased mobility3 of the helix involvved in the activation of lipoprotein4 lipase. Phyre2 PDB 2cho chain A domain 3 Region: 131 - 139 Aligned: 9 Modelled: 9 Confidence: 9.2% Identity: 33% Fold: Zincin-like Superfamily: beta-N-acetylhexosaminidase-like domain Family: Hyaluronidase N-terminal domain-like Phyre2 1 c5ietA_ 2 c2lseA_ 3 c2veeC_ 4 d2bmob1 5 c2l6fA_ 6 c5oheA_ 7 d2gjxa2 8 d1qbaa4 9 d2csba1 10 d2cbia3 11 c4tzoC_ 12 d1m98a1 13 d1nowa2 14 d2aq0a1 15 c4xy3A_ 16 c2gbxF_ 17 d1jaka2 18 d1j9ia_ 19 c1o8tA_ 20 d2choa3 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68