1	.	.	.	.	.	.	.	.	10	.	.	.	.	.	.	.	.	.	20	.	.	.	.	.	.	.	.	.	30	.	.	.	.	.	.	.	.	.	40	.	.	.	.	.	.	.	.	.	50	.	.	.	.	.	.	.	.	.	60
Sequence		L	S	A	P	A	V	A	A	G	P	T	A	A	G	A	T	A	A	R	P	A	T	T	R	V	T	I	L	T	G	R	R	M	T	D	L	V	L	P	A	A	V	P	M	E	T	Y	I	D	D	T	V	A	V	L	S	E	V	L	E
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?																																								?
Disorder confidence
		.	.	.	.	.	.	.	.	.	70	.	.	.	.	.	.	.	.	.	80	.	.	.	.	.	.	.	.	.	90	.	.	.	.	.	.	.	.	.	100	.	.	.	.	.	.	.	.	.	110	.	.	.	.	.	.	.	.	.	120
Sequence		D	T	P	A	D	V	L	G	G	F	D	F	T	A	Q	G	V	W	A	F	A	R	P	G	S	P	P	L	K	L	D	Q	S	L	D	D	A	G	V	V	D	G	S	L	L	T	L	V	S	V	S	R	T	E	R	Y	R	P	L	V
Secondary structure
SS confidence
Disorder		?	?	?	?	?	?	?	?	?	?	?	?	?		?											?	?	?	?	?				?				?	?											?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	130	.	.	.	.	.	.	.	.	.	140	.	.	.	.	.	.	.	.	.	150	.	.	.	.	.	.	.	.	.	160	.	.	.	.	.	.	.	.	.	170	.	.	.	.	.	.	.	.	.	180
Sequence		E	D	V	I	D	A	I	A	V	L	D	E	S	P	E	F	D	R	T	A	L	N	R	F	V	G	A	A	I	P	L	L	T	A	P	V	I	G	M	A	M	R	A	W	W	E	T	G	R	S	L	W	W	P	L	A	I	G	I	L
Secondary structure
SS confidence
Disorder													?	?	?	?	?																										?	?			?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	190	.	.	.	.	.	.	.	.	.	200	.	.	.	.	.	.	.	.	.	210	.	.	.	.	.	.	.	.	.	220	.	.	.	.	.	.	.	.	.	230	.	.	.	.	.	.	.	.	.	240
Sequence		G	I	A	V	L	V	G	S	F	V	A	N	R	F	Y	Q	S	G	H	L	A	E	C	L	L	V	T	T	Y	L	L	I	A	T	A	A	A	L	A	V	P	L	P	R	G	V	N	S	L	G	A	P	Q	V	A	G	A	A	T	A
Secondary structure
SS confidence
Disorder													?	?	?	?		?																											?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	250	.	.	.	.	.	.	.	.	.	260	.	.	.	.	.	.	.	.	.	270	.	.	.	.	.	.	.	.	.	280	.	.	.	.	.	.	.	.	.	290	.	.	.	.	.	.	.	.	.	300
Sequence		V	L	F	L	T	L	M	T	R	G	G	P	R	K	R	H	E	L	A	S	F	A	V	I	T	A	I	A	V	I	A	A	A	A	A	F	G	Y	G	Y	Q	D	W	V	P	A	G	G	I	A	F	G	L	F	I	V	T	N	A	A
Secondary structure
SS confidence
Disorder										?	?				?																						?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	310	.	.	.	.	.	.	.	.	.	320	.	.	.	.	.	.	.	.	.	330	.	.	.	.	.	.	.	.	.	340	.	.	.	.	.	.	.	.	.	350	.	.	.	.	.	.	.	.	.	360
Sequence		K	L	T	V	A	V	A	R	I	A	L	P	P	I	P	V	P	G	E	T	V	D	N	E	E	L	L	D	P	V	A	T	P	E	A	T	S	E	E	T	P	T	W	Q	A	I	I	A	S	V	P	A	S	A	V	R	L	T	E	R
Secondary structure
SS confidence
Disorder									?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	370	.	.	.	.	.	.	.	.	.	380	.	.	.	.	.	.	.	.	.	390	.	.	.	.	.	.	.	.	.	400	.	.	.	.	.	.	.	.	.	410	.	.	.	.	.	.	.	.	.	420
Sequence		S	K	L	A	K	Q	L	L	I	G	Y	V	T	S	G	T	L	I	L	A	A	G	A	I	A	V	V	V	R	G	H	F	F	V	H	S	L	V	V	A	G	L	I	T	T	V	C	G	F	R	S	R	L	Y	A	E	R	W	C	A
Secondary structure
SS confidence
Disorder
Disorder confidence
		.	.	.	.	.	.	.	.	.	430	.	.	.	.	.	.	.	.	.	440	.	.	.	.	.	.	.	.	.	450	.	.	.	.	.	.	.	.	.	460	.	.	.	.	.	.	.	.	.	470	.	.	.	.	.	.	.	.	.	480
Sequence		W	A	L	L	A	A	T	V	A	I	P	T	G	L	T	A	K	L	I	I	W	Y	P	H	Y	A	W	L	L	L	S	V	Y	L	T	V	A	L	V	A	L	V	V	V	G	S	M	A	H	V	R	R	V	S	P	V	V	K	R	T
Secondary structure
SS confidence
Disorder																					?																											?	?
Disorder confidence
		.	.	.	.	.	.	.	.	.	490	.	.	.	.	.	.	.	.	.	500	.	.	.	.	.	.	.	.	.	510	.
Sequence		L	E	L	I	D	G	A	M	I	A	A	I	I	P	M	L	L	W	I	T	G	V	Y	D	T	V	R	N	I	R	F
Secondary structure
SS confidence
Disorder																													?	?	?	?
Disorder confidence

Confidence Key High(9)                     Low (0)

? Disordered ( 26%) Alpha helix ( 56%) Beta strand ( 5%) TM helix ( 46%) (View membrane topology prediction)

Rank Aligned region

PDB 4kv3 chain A Region: 21 - 109 Aligned: 89 Modelled: 89 Confidence: 99.7% Identity: 100% PDB header:protein transport Chain: A: PDB Molecule:chimera fusion protein of esx-1 secretion system protein PDBTitle: ubiquitin-like domain of the mycobacterium tuberculosis type vii2 secretion system protein eccd1 as maltose-binding protein fusion Phyre2 PDB 1j8c chain A Region: 4 - 108 Aligned: 88 Modelled: 89 Confidence: 97.1% Identity: 18% Fold: beta-Grasp (ubiquitin-like) Superfamily: Ubiquitin-like Family: Ubiquitin-related Phyre2 PDB 2klc chain A Region: 20 - 115 Aligned: 79 Modelled: 80 Confidence: 96.7% Identity: 18% PDB header:structural genomics, unknown function Chain: A: PDB Molecule:ubiquilin-1; PDBTitle: nmr solution structure of human ubiquitin-like domain of ubiquilin 1,2 northeast structural genomics consortium (nesg) target ht5a Phyre2 PDB 1yqb chain A domain 1 Region: 18 - 115 Aligned: 81 Modelled: 81 Confidence: 96.4% Identity: 20% Fold: beta-Grasp (ubiquitin-like) Superfamily: Ubiquitin-like Family: Ubiquitin-related Phyre2 PDB 2dzm chain A Region: 14 - 118 Aligned: 88 Modelled: 89 Confidence: 96.3% Identity: 9% PDB header:structural genomics unknown function Chain: A: PDB Molecule:fas-associated factor 1; PDBTitle: solution structure of the ubiquitin-like domain in human2 fas-associated factor 1 (hfaf1) Phyre2 PDB 4hwi chain B Region: 22 - 108 Aligned: 70 Modelled: 70 Confidence: 96.1% Identity: 20% PDB header:chaperone/apoptosis Chain: B: PDB Molecule:bag family molecular chaperone regulator 1; PDBTitle: crystal structure of atbag1 in complex with hsp70 Phyre2 PDB 2kma chain A Region: 24 - 110 Aligned: 72 Modelled: 72 Confidence: 95.6% Identity: 17% PDB header:structural protein Chain: A: PDB Molecule:talin 1; PDBTitle: nmr structure of the f0f1 double domain (residues 1-202) of2 the talin ferm domain Phyre2 PDB 1v86 chain A Region: 6 - 115 Aligned: 92 Modelled: 96 Confidence: 95.5% Identity: 13% Fold: beta-Grasp (ubiquitin-like) Superfamily: Ubiquitin-like Family: Ubiquitin-related Phyre2 PDB 2bwf chain A domain 1 Region: 24 - 110 Aligned: 70 Modelled: 70 Confidence: 95.5% Identity: 14% Fold: beta-Grasp (ubiquitin-like) Superfamily: Ubiquitin-like Family: Ubiquitin-related Phyre2 PDB 1wx7 chain A domain 1 Region: 12 - 115 Aligned: 87 Modelled: 88 Confidence: 95.3% Identity: 20% Fold: beta-Grasp (ubiquitin-like) Superfamily: Ubiquitin-like Family: Ubiquitin-related Phyre2 PDB 5yca chain A Region: 21 - 125 Aligned: 88 Modelled: 89 Confidence: 95.3% Identity: 13% PDB header:membrane protein Chain: A: PDB Molecule:ubiquitin-like protein smt3,bouquet formation protein 4; PDBTitle: crystal structure of inner membrane protein bqt4 in complex with lem2 Phyre2 PDB 2kzr chain A Region: 24 - 118 Aligned: 78 Modelled: 78 Confidence: 95.1% Identity: 18% PDB header:hydrolase Chain: A: PDB Molecule:ubiquitin thioesterase otu1; PDBTitle: solution nmr structure of ubiquitin thioesterase otu1 (ec 3.1.2.-)2 from mus musculus, northeast structural genomics consortium target3 mmt2a Phyre2 PDB 2kd0 chain A Region: 18 - 107 Aligned: 73 Modelled: 76 Confidence: 94.9% Identity: 15% PDB header:signaling protein Chain: A: PDB Molecule:lrr repeats and ubiquitin-like domain-containing PDBTitle: nmr solution structure of o64736 protein from arabidopsis2 thaliana. northeast structural genomics consortium mega3 target ar3445a Phyre2 PDB 1a5r chain A Region: 7 - 108 Aligned: 85 Modelled: 86 Confidence: 94.9% Identity: 5% Fold: beta-Grasp (ubiquitin-like) Superfamily: Ubiquitin-like Family: Ubiquitin-related Phyre2 PDB 1v5o chain A Region: 24 - 119 Aligned: 80 Modelled: 80 Confidence: 94.6% Identity: 15% Fold: beta-Grasp (ubiquitin-like) Superfamily: Ubiquitin-like Family: Ubiquitin-related Phyre2 PDB 1wx8 chain A domain 1 Region: 18 - 112 Aligned: 78 Modelled: 78 Confidence: 94.6% Identity: 17% Fold: beta-Grasp (ubiquitin-like) Superfamily: Ubiquitin-like Family: Ubiquitin-related Phyre2 PDB 3m63 chain B Region: 24 - 107 Aligned: 67 Modelled: 67 Confidence: 94.6% Identity: 18% PDB header:ligase/protein binding Chain: B: PDB Molecule:ubiquitin domain-containing protein dsk2; PDBTitle: crystal structure of ufd2 in complex with the ubiquitin-like (ubl)2 domain of dsk2 Phyre2 PDB 3goe chain A Region: 21 - 108 Aligned: 71 Modelled: 71 Confidence: 94.2% Identity: 8% PDB header:recombination, replication Chain: A: PDB Molecule:dna repair protein rad60; PDBTitle: molecular mimicry of sumo promotes dna repair Phyre2 PDB 2k8h chain A Region: 4 - 113 Aligned: 93 Modelled: 94 Confidence: 93.9% Identity: 13% PDB header:signaling protein Chain: A: PDB Molecule:small ubiquitin protein; PDBTitle: solution structure of sumo from trypanosoma brucei Phyre2 PDB 1v5t chain A Region: 24 - 117 Aligned: 80 Modelled: 80 Confidence: 93.8% Identity: 9% Fold: beta-Grasp (ubiquitin-like) Superfamily: Ubiquitin-like Family: Ubiquitin-related Phyre2 1 c4kv3A_ 2 d1j8ca_ 3 c2klcA_ 4 d1yqba1 5 c2dzmA_ 6 c4hwiB_ 7 c2kmaA_ 8 d1v86a_ 9 d2bwfa1 10 d1wx7a1 11 c5ycaA_ 12 c2kzrA_ 13 c2kd0A_ 14 d1a5ra_ 15 d1v5oa_ 16 d1wx8a1 17 c3m63B_ 18 c3goeA_ 19 c2k8hA_ 20 d1v5ta_ 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126