About

Pebble is the Rock lab's web portal for designing, analyzing, visualizing, and sharing functional genomics, genetic interaction, and systems biology datasets in mycobacteria. Built to accelerate research on Mycobacterium tuberculosis and related pathogens, the platform brings together purpose-built computational tools and curated experimental data in a single, openly accessible resource for the global mycobacteria research community. Researchers can use Pebble to design CRISPRi sgRNA libraries, evaluate guide specificity and off-target risk, explore gene-level annotations and protein co-folding data, and filter the mycobacterial genome by vulnerability, essentiality, and other quantitative phenotypes derived from large-scale screens.

The tools and data presented here are the product of many contributors. Pebble reflects the close, ongoing collaboration between the Rock lab at Rockefeller University and the Schnappinger and Ehrt labs at Weill Cornell Medicine, along with the many trainees, staff scientists, and collaborators whose experiments and analyses underpin the resource.

Pebble was made possible through the generous support of the Potts Memorial Foundation and the TB Drug Accelerator.