Rv1136 (-)

background  +5   0  -5 -10 -15 sgRNA L2FC (+ATc/–ATc) TnSeq Gene Essentiality Predictions (1, 2) Essential Growth Defect Non-Essential Growth Advantage Unknown Operon Legend (3) Operon (1) PMID: 28096490 (2) PMID: 31388080 (3) PMID: 26536359 Rv1134 Rv1135A PPE16 Rv1136 Rv1137c Rv1138c Rv1139c Rv1140
Species: M. tuberculosis
Strain: H37Rv
PATRIC Annotation: enoyl-CoA hydratase
Synonyms:
M. smegmatis homologs MSMEG5198, MSMEG4709, MSMEG2227, MSMEG4852, MSMEG1390, [+ 22 remaining orthologs]
M. abscessus homologs MAB4588c, MAB2058, MAB0905, MAB3857c, MAB2737c, [+ 12 remaining orthologs]
Gene Start: 1264611
Gene End: 1264952
Vulnerability Index (VI):
VI Lower Bound:
VI Upper Bound:
[AlphaFold] [Phyre2] [UniProt] [MycoBrowser] [Orthologs] [U19] [TnSeq DB]

Essentiality:

Call Condition Type Source Notes
Non Essential in vitro TnSeq [DeJesus et al. (2017)]
Unknown in vitro CRISPRi [Bosch & DeJesus et al. (2021)]


DNA and Protein Sequence help

DNA Sequence

ACACCTCATGCAGCTTGGCAATCAAAACACTATGAGATTCGCAGGGCGGCCTCAGCGTTTTCGCCAAAGCGCTTACCCCCTGTTCAACCCCAACAGCGCGATCGCGCTTGGCCACCCATTCGGCGGCTCGGGGGCACGGTTGATGACTACAGTGCTACACCACATGCCGGACAAGGGAATTCGCTACGGCTTACAGACGATGTGCGAGGGCCGCGGCCAAGCCAATGCCACCATTGTGGAGTTGCTGTGACAGCGACCGATAGCCAGCCGGCGGCGTTGTCGAGTACCGCGACAATGTCATGGTCATTACGATCAATCGGCCGGAAGCCCGCAATGCGGTCAATGGTGCCGTCAGCATCGTGGTTGGAGACGCGCTGGAAGAAGCGCACGACAACCCCGATGTGCGGGCCGTGGTGATCACCGGCGCCGGCGACAAGTCGCTTTGCGCCGGTGCCGACCTCAAGGCGATCGCACGCCGGGAGAACCCGTACCACCCGCATCACGGCGAGTGGGGCATCGCCGGTTACAGGCACCATTTCATCGACAAGCCGACCAGCGCCGCGGTCAGTGGCACGGCCTTGGACGACGGTGCCGAGCCAGCGCTGGCCAGCGACCTGGTGGTGGCCGACGAGCACACCTAA

Protein Sequence

MVITINRPEARNAVNGAVSIVVGDALEEAHDNPDVRAVVITGAGDKSLCAGADLKAIARRENPYHPHHGEWGIAGYRHHFIDKPTSAAVSGTALDDGAEPALASDLVVADEHT_ 
Gene not present in the RLC0012 CRISPRi library.

Specific References

General References