rv1136
rv1136
enoyl-CoA hydratase
M. tuberculosis · H37Rv
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H37Rv Coordinates: 1264611 – 1264952
Vulnerability Index (VI):
M. smegmatis homologs MSMEG5198, MSMEG4709, MSMEG2227, MSMEG4852, MSMEG1390, [+ 22 remaining orthologs]
M. abscessus homologs MAB4588c, MAB2058, MAB0905, MAB3857c, MAB2737c, [+ 12 remaining orthologs]
 +5   0  -5 -10 -15 sgRNA L2FC (+ATc/–ATc) TnSeq Gene Essentiality Predictions (1, 2) Essential Growth Defect Non-Essential Growth Advantage Unknown Operon Legend (3) Operon (1) PMID: 28096490 (2) PMID: 31388080 (3) PMID: 26536359 (4) PMID: 38418874 Rv1134 Rv1135A PPE16 Rv1136 Rv1137c Rv1138c Rv1139c Rv1140
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>rv1136_Rv1136_dna
ACACCTCATGCAGCTTGGCAATCAAAACACTATGAGATTCGCAGGGCGGCCTCAGCGTTTTCGCCAAAGCGCTTACCCCCTGTTCAACCCCAACAGCGCGATCGCGCTTGGCCACCCATTCGGCGGCTCGGGGGCACGGTTGATGACTACAGTGCTACACCACATGCCGGACAAGGGAATTCGCTACGGCTTACAGACGATGTGCGAGGGCCGCGGCCAAGCCAATGCCACCATTGTGGAGTTGCTGTGACAGCGACCGATAGCCAGCCGGCGGCGTTGTCGAGTACCGCGACAATGTCATGGTCATTACGATCAATCGGCCGGAAGCCCGCAATGCGGTCAATGGTGCCGTCAGCATCGTGGTTGGAGACGCGCTGGAAGAAGCGCACGACAACCCCGATGTGCGGGCCGTGGTGATCACCGGCGCCGGCGACAAGTCGCTTTGCGCCGGTGCCGACCTCAAGGCGATCGCACGCCGGGAGAACCCGTACCACCCGCATCACGGCGAGTGGGGCATCGCCGGTTACAGGCACCATTTCATCGACAAGCCGACCAGCGCCGCGGTCAGTGGCACGGCCTTGGACGACGGTGCCGAGCCAGCGCTGGCCAGCGACCTGGTGGTGGCCGACGAGCACACCTAA

Protein Sequence 

>Rv1136_Rv1136_protein
MVITINRPEARNAVNGAVSIVVGDALEEAHDNPDVRAVVITGAGDKSLCAGADLKAIARRENPYHPHHGEWGIAGYRHHFIDKPTSAAVSGTALDDGAEPALASDLVVADEHT

Essentiality:

Call Condition Type Source Notes
Non Essential in vitro TnSeq [DeJesus et al. (2017)]
Unknown in vitro CRISPRi [Bosch & DeJesus et al. (2021)]

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