mazE5 aka mazE-mt5
rv1943c
antitoxin MazE5
M. tuberculosis · H37Rv
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H37Rv Coordinates: 2194977 – 2195354
Vulnerability Index (VI):
M. smegmatis homologs
M. abscessus homologs
 +5   0  -5 -10 -15 sgRNA L2FC (+ATc/–ATc) TnSeq Gene Essentiality Predictions (1, 2) Essential Growth Defect Non-Essential Growth Advantage Unknown Operon Legend (3) Operon TSS Legend ? Ju, 2024 (5) Cortes, 2013 (4) Shell, 2015 (3) (1) PMID: 28096490 (2) PMID: 31388080 (3) PMID: 26536359 (4) PMID: 24268774 (5) PMID: 38418874 ephB Rv1939 ribA1 Rv1941 Rv1942c Rv1943c Rv1944c Rv1945 lppG Rv1947
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>rv1943c_mazE5_dna
GCACCCGCTGTACTGCCGGAGGATGCAGCAAAAGCTGGTCGAATTCGCCGAGGCTGGTTTCCCAGGACTGGCGGTCGCCGCGATCCGCGTGGCACCCTTCGCTGCCTGGTGCGCCGAACAGGGTCAGGAGCCGGACTCGCCGGAGGCCCGCGCCGAGTATGCCGCGTACCTGACAGCACACGGTGACCACGATGTGATGGCCTGGCCACCGGGCCGCAACCAACAGTGCTGGTGCGGCTCGGGGCACAAGTACAAAAAGTGTTGTGCCGCAGCGTCGTTCATCGACACGGAACCCGCACCGTGAAGACGGCCCGGTTGCAGGTGACGTTGCGCTGCGCGGTAGACCTCATCAATTCGTCCAGCGACCAATGTTTCGCCCGTATCGAGCACGTTGCGTCCGATCAGGCGGATCCACGCCCCGGAGTGTGGCATAGTAGTGGCATGAATCGCATACGGCTGAGCACTACTGTCGACGCCGCACTCTTGACAAGTGCGCGCGACATGCGGGCAGGAATCACTGACGCAGCCCTCATCGATGAGGCCCTTGCGGCATTACTGGCTCGTCATCGATCGGCCGAGGTGGATGCCAGCTATGCGGCCTACGACAAGCACCCGGTCGATGAGCCCGACGAGTGGGGCGATCTAGCGTCGTGGCGGCGGGCGGCTGGAGACTCGTGA

Protein Sequence 

>Rv1943c_MazE5_protein
VKTARLQVTLRCAVDLINSSSDQCFARIEHVASDQADPRPGVWHSSGMNRIRLSTTVDAALLTSARDMRAGITDAALIDEALAALLARHRSAEVDASYAAYDKHPVDEPDEWGDLASWRRAAGDS

Essentiality:

Call Condition Type Source Notes
Non Essential in vitro TnSeq [DeJesus et al. (2017)]
Unknown in vitro CRISPRi [Bosch & DeJesus et al. (2021)]

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