Rv1943c (mazE5)

background  +5   0  -5 -10 -15 sgRNA L2FC (+ATc/–ATc) TnSeq Gene Essentiality Predictions (1, 2) Essential Growth Defect Non-Essential Growth Advantage Unknown Operon Legend (3) Operon (1) PMID: 28096490 (2) PMID: 31388080 (3) PMID: 26536359 ephB Rv1939 ribA1 Rv1941 Rv1942c Rv1943c Rv1944c Rv1945 lppG Rv1947
Species: M. tuberculosis
Strain: H37Rv
PATRIC Annotation: antitoxin MazE5
Synonyms: mazE-mt5
M. smegmatis homologs
M. abscessus homologs
Gene Start: 2194977
Gene End: 2195354
Vulnerability Index (VI):
VI Lower Bound:
VI Upper Bound:
[AlphaFold] [Phyre2] [UniProt] [MycoBrowser] [Orthologs] [U19] [TnSeq DB]

Essentiality:

Call Condition Type Source Notes
Non Essential in vitro TnSeq [DeJesus et al. (2017)]
Unknown in vitro CRISPRi [Bosch & DeJesus et al. (2021)]


DNA and Protein Sequence help

DNA Sequence

GCACCCGCTGTACTGCCGGAGGATGCAGCAAAAGCTGGTCGAATTCGCCGAGGCTGGTTTCCCAGGACTGGCGGTCGCCGCGATCCGCGTGGCACCCTTCGCTGCCTGGTGCGCCGAACAGGGTCAGGAGCCGGACTCGCCGGAGGCCCGCGCCGAGTATGCCGCGTACCTGACAGCACACGGTGACCACGATGTGATGGCCTGGCCACCGGGCCGCAACCAACAGTGCTGGTGCGGCTCGGGGCACAAGTACAAAAAGTGTTGTGCCGCAGCGTCGTTCATCGACACGGAACCCGCACCGTGAAGACGGCCCGGTTGCAGGTGACGTTGCGCTGCGCGGTAGACCTCATCAATTCGTCCAGCGACCAATGTTTCGCCCGTATCGAGCACGTTGCGTCCGATCAGGCGGATCCACGCCCCGGAGTGTGGCATAGTAGTGGCATGAATCGCATACGGCTGAGCACTACTGTCGACGCCGCACTCTTGACAAGTGCGCGCGACATGCGGGCAGGAATCACTGACGCAGCCCTCATCGATGAGGCCCTTGCGGCATTACTGGCTCGTCATCGATCGGCCGAGGTGGATGCCAGCTATGCGGCCTACGACAAGCACCCGGTCGATGAGCCCGACGAGTGGGGCGATCTAGCGTCGTGGCGGCGGGCGGCTGGAGACTCGTGA

Protein Sequence

VKTARLQVTLRCAVDLINSSSDQCFARIEHVASDQADPRPGVWHSSGMNRIRLSTTVDAALLTSARDMRAGITDAALIDEALAALLARHRSAEVDASYAAYDKHPVDEPDEWGDLASWRRAAGDS_ 
Gene not present in the RLC0012 CRISPRi library.

Specific References

General References