Rv2278 (-)

background  +5   0  -5 -10 -15 sgRNA L2FC (+ATc/–ATc) TnSeq Gene Essentiality Predictions (1, 2) Essential Growth Defect Non-Essential Growth Advantage Unknown Operon Legend (3) Operon (1) PMID: 28096490 (2) PMID: 31388080 (3) PMID: 26536359 RVBD2274A Rv2275 cyp121 Rv2277c Rv2278 Rv2279 Rv2280 pitB
Species: M. tuberculosis
Strain: H37Rv
PATRIC Annotation: transposase
Synonyms:
M. smegmatis homologs MSMEG2676, MSMEG0724, MSMEG1720, MSMEG1716, MSMEG5096, [+ 5 remaining orthologs]
M. abscessus homologs MAB2087
Gene Start: 2550075
Gene End: 2550401
Vulnerability Index (VI):
VI Lower Bound:
VI Upper Bound:
[AlphaFold] [Orthologs] [Phyre2] [UniProt] [MycoBrowser] [U19] [TnSeq DB]

Essentiality:

Call Condition Type Source Notes
Non Essential in vitro TnSeq [DeJesus et al. (2017)]
Unknown in vitro CRISPRi [Bosch & DeJesus et al. (2021)]


DNA and Protein Sequence help

DNA Sequence

GCCGTCGGTCAACGTTGCCAGATCGGACGGACGATACAGCACCGGCACGCCATCGCTGCTGACCTGGACGGTCAGCCACATGCCATCCACACCAGCTGCGACTGCGTTGGTAATCGCCAGAACGGTGTTCTCGGGAAAATCGCGCGTACCCGCGCGATGCGCGACAATCATCGGGTCGTCAGTCTGGCCCAGCGGCAAAGCATCCGCCACACCGCAAGTCCCTCCCAAGGCGATCACCAGCGCCACCGTGAACCGCCCCGGCATGTCCGGAGACTCCAGTTCTTGGAAAGGATGGGGTCATGTCAGGTGGTTCATCGAGGAGGTACCCGCCGGAGCTGCGTGAGCGGGCGGTGCGGATGGTCGCAGAGATCCGCGGTCAGCACGATTCGGAGTGGGCAGCGATCAGTGAGGTCGCCCGTCTACTTGGTGTTGGCTGCGCGGAGACGGTGCGTAAGTGGGTGCGCCAGGCGCAGGTCGATGCCGGCGCACGGCCCGGGACCACGACCGAAGAATCCGCTGAGCTGAAGCGCTTGCGGCGGGACAACGCCGAATTGCGAAGGGCGAACGCGATTTTAAAGACCGCGTCGGCTTTCTTCGCGGCCGAGCTCGACCGGCCAGCACGCTAA

Protein Sequence

MSGGSSRRYPPELRERAVRMVAEIRGQHDSEWAAISEVARLLGVGCAETVRKWVRQAQVDAGARPGTTTEESAELKRLRRDNAELRRANAILKTASAFFAAELDRPAR_ 
Gene not present in the RLC0012 CRISPRi library.

Specific References

General References