echA18.1
rv3374
enoyl-CoA hydratase EchA18.1
M. tuberculosis · H37Rv
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H37Rv Coordinates: 3788548 – 3788796
Vulnerability Index (VI):
M. smegmatis homologs
M. abscessus homologs
background  +5   0  -5 -10 -15 sgRNA L2FC (+ATc/–ATc) TnSeq Gene Essentiality Predictions (1, 2) Essential Growth Defect Non-Essential Growth Advantage Unknown Operon Legend (3) Operon (1) PMID: 28096490 (2) PMID: 31388080 (3) PMID: 26536359 Rv3371 otsB2 RVBD3372A echA18 echA18.1 amiD Rv3376 Rv3377c
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>rv3374_echA18.1_dna
ACGCCGCGGAGTACAACGAGAGCCTGGCCGTCTGCCTGAGGGCGTTGACCACGATGCCGATCCCAGTCATCGCGGCGGTCCGGGGGCTCGCCGTCGGTGGCGGCTGTGAGCTGGCGACGGCCTGCGATGTGTGCATCGCGACCGACGACGCGCGCTTCGGCATCCCGCTGGGCAAGCTCGGCGTCACGACGGGCTTCACCGAGGCGGACACCGTCGCGCGCCTCATCGGTCCGGCGGCGCTGAAGTATCTGTTGTTCAGCGGAGAACTGATCGGCATTGAGGAAGCCGCCCGCTGGTGATTGGTGCAAAAGGTCGTCGCACCACAGGATTTGGCGGCCGCGACGGCCAAACTGGTCGGCCAGGTCTGTCGGCAATCCGCGGTGACCATGCGTGCGGCGAAGGTGGTCGCCAACATGCACGGCCGAGCGCTGACCGGCGCCGACACCGATGCGCTGATCCGGTTCGGTGTCGAAGCCTACGAGGGGGCGGACCTACGCGAAGGGGTGGCGGCCTTCAGCCAGGGACGCCCACCCAAATTTGATGATTAG

Protein Sequence 

>Rv3374_EchA18.1_protein
LVQKVVAPQDLAAATAKLVGQVCRQSAVTMRAAKVVANMHGRALTGADTDALIRFGVEAYEGADLREGVAAFSQGRPPKFDD

Essentiality:

Call Condition Type Source Notes
Non Essential in vitro TnSeq [DeJesus et al. (2017)]
Unknown in vitro CRISPRi [Bosch & DeJesus et al. (2021)]

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