Rv3453 (-)

background  +5   0  -5 -10 -15 sgRNA L2FC (+ATc/–ATc) TnSeq Gene Essentiality Predictions (1, 2) Essential Growth Defect Non-Essential Growth Advantage Unknown Operon Legend (3) Operon (1) PMID: 28096490 (2) PMID: 31388080 (3) PMID: 26536359 Rv3450c cut3 cut4 Rv3453 Rv3454 truA rplQ rpoA
Species: M. tuberculosis
Strain: H37Rv
PATRIC Annotation: transmembrane protein
Synonyms:
M. smegmatis homologs
M. abscessus homologs MAB2635c
Gene Start: 3874583
Gene End: 3874915
Vulnerability Index (VI):
VI Lower Bound:
VI Upper Bound:
[AlphaFold] [Phyre2] [UniProt] [MycoBrowser] [Orthologs] [U19] [TnSeq DB]

Essentiality:

Call Condition Type Source Notes
Non Essential in vitro TnSeq [DeJesus et al. (2017)]
Unknown in vitro CRISPRi [Bosch & DeJesus et al. (2021)]


DNA and Protein Sequence help

DNA Sequence

GGCGCGTTTCGTCGCGAGCAGGATCTAACGCGAGCCGCCCCATAGATTCCGGCTAAGCAACGGCTGCGCCGCCGCCCGGCCACGAGTGACCGCCGCCGACTGGCACACCGCTTACCACGGCCTTATGCTGGCGCCGGACCCCGCCCGCCAGGCGCGCCGCCCGTCAACGCAGCCGAATGCGCATTTGTCCGCCGAATGCGCCGCGATGAACCGCAATCATTTCACCGGAAGGGAAGTGTGCGGACACGCTAACCGGACGCTCGGGCTAACTTCGACCGCTATTGCGCTGAGGAGGGTTGATGCCGGGCGTCATAACAAACAGTGAAAGCCCAACCGCAGCCGACCACGACAGAATTACGGCCACCAGAGAGACGCTGGAGGATTACACACTGCGGTTGGCGCCGCGCAGCTATCGCAGGTGGCCCCCGGCGGTGGTGGGCATCTCCGCTCTCGGCGGCATCGCCTACCTGGCGGACTTCGCGATCGGCGCCAATGTCGGTATCACGTGGGGTACCGCGAACGCGCTGTGCGGAATCGCAATCTTCGCACTGGTGGTCTTCGTCACCGGCTTGCCGCTGGCCTACTACGCGGCGCGGTACAACATCGACCTGGATCTGATTTACCCGCGGTAG

Protein Sequence

MPGVITNSESPTAADHDRITATRETLEDYTLRLAPRSYRRWPPAVVGISALGGIAYLADFAIGANVGITWGTANALCGIAIFALVVFVTGLPLAYYAARYNIDLDLIYPR_ 
Gene not present in the RLC0012 CRISPRi library.

Specific References

General References