MSMEG1721 (MSMEG1721)

background  +5   0  -5 -10 -15 sgRNA L2FC (+ATc/–ATc) TnSeq Gene Essentiality Predictions (1, 2) Essential Growth Defect Non-Essential Growth Advantage Unknown Operon Legend (3) Operon (1) PMID: 28096490 (2) PMID: 31388080 (3) PMID: 26536359 MSMEG1717 MSMEG1720 MSMEG1721 MSMEG1722 MSMEG1723 MSMEG1724 MSMEG1725 MSMEG1726
Species: M. smegmatis
Strain: MC2-155
PATRIC Annotation: -
Synonyms:
M. tuberculosis homologs RVBD3475, RVBD3380c, RVBD3326, RVBD3187, RVBD3185, [+ 13 remaining orthologs]
M. abscessus homologs MAB2086c, MAB2088
Gene Start: 1816151
Gene End: 1817104
Vulnerability Index (VI):
VI Lower Bound:
VI Upper Bound:
[AlphaFold] [Orthologs] [Phyre2] [UniProt] [MycoBrowser] [TnSeq DB]

Essentiality:

Call Condition Type Source Notes
Non Essential in vitro TnSeq [Akusobi et al. (2022)]
Unknown in vitro CRISPRi [Bosch & DeJesus et al. (2021)]


DNA and Protein Sequence help

DNA Sequence

GACGAGCTGAAGGTGCGGGCGGTGCAGATGGTGGCCGATCTGCGCAGCGAGACAGTTTCGGAGTGGGAGGCGATGGGCCGGGTTGCTGACCTGCTGGGCGTCGGTACTGCCGAAACGGTGCGCAAATGGGTCCGCCAGGCTGAGATCGACGCCGGCTCTCGGGCGGGGCAGACCAGCGAGGAATCCGAGGTCCTGCGCAAGCTGCGCCGGGAGAATGCCGAACTCAAGCGGGCCAACGCGATCTTGAAGGCGGCCTCGGTTTTCTTCGCCGCCGAGCTCGACCGGCCCTCTCAGTAGTCGTGGAGTTCATCAGCGCCCACCAGCACATGCGGGTGGGCGTTGATGGTCTCAAGTGGGGTGTCGAGTCGATGTGCGCTGTGCTTTCCGAGTACGGCGTCACGATCGCCCCGTCGACGTATTACGCCCACCGCGCCCGTCAGGGCCCCTCGAAAGCCGACTGGGCCGATGCGCAGGTGATCGATGCGATCTGGCAGCTTCGCCAATCGCAGAGTCTGTACCGAGTCCTGGGCGCTCGTAAGACATGGATTGTATTGCGCACCAATGGTATCGACGTATCGCGCTGTGTCGTGGAACGGGTCATGCGGGAGATGGGTTGGCGGGGTGCGTGCAAGCGCCGGCGGGTGCGCACCACCGTCGCCGATCCGGCAGCGACGCGAGCCCCGGATCGGGTCCGGCGTAATTTCGTCGCCGGTGCGCCTGACCGATTGTGGGTGGCCGATTTCACCTACTGCCGGACTCGTGCCGGCTGGGCCTACACGGCGTTCGTCACCGATGTCTATGCCCGCAAGATCGTGGGTTGGAAGGTGGCTACCGAGATGACCCAGAAGCTGGTGACCGATGCGATCGACCACGCTATCGACACCAGAAAGCGTTCGGGTGCAGCATCTTTGGATTCACTTATCCACCACAGCGACGCGGGCTCGCAATACACCGCGGTCGCGTTCACCGAACGTCTGGCCGCTGAGGGGATCCTGCCTTCAGTCGGATCCGTCGGGGATAGTTTCGATAATGCTCTGGCCGAATCGGTGAACAGCAGCTACAAGACCGAACTCATCGACCGCCAGCCGCTCTATCCCGGTGCCACCGAACTGGCGCTGGGGACCGCCGAATGGGTGGCCTTCTACAACCGTCAGCGACCCAACGGCTACTGCCAGGACCTGACCCCCGATCGGGCCGAAGCGCTCTACTACCATCGCCAACGGCACCCTCATGCCGAGGAGGCACTCAGATAA

Protein Sequence

VEFISAHQHMRVGVDGLKWGVESMCAVLSEYGVTIAPSTYYAHRARQGPSKADWADAQVIDAIWQLRQSQSLYRVLGARKTWIVLRTNGIDVSRCVVERVMREMGWRGACKRRRVRTTVADPAATRAPDRVRRNFVAGAPDRLWVADFTYCRTRAGWAYTAFVTDVYARKIVGWKVATEMTQKLVTDAIDHAIDTRKRSGAASLDSLIHHSDAGSQYTAVAFTERLAAEGILPSVGSVGDSFDNALAESVNSSYKTELIDRQPLYPGATELALGTAEWVAFYNRQRPNGYCQDLTPDRAEALYYHRQRHPHAEEALR_ 
Gene not present in the RLC0011 CRISPRi library.

Specific References

General References