rrlA
ms3756
-
M. smegmatis · MC2-155
[AlphaFold] [Orthologs] [UniProt] [MycoBrowser] [TnSeq DB] [SeqHub]
MC2-155 Coordinates: 3820128 – 3823247
Vulnerability Index (VI):
M. tuberculosis homologs
M. abscessus homologs
 +5   0  -5 -10 -15 sgRNA L2FC (+ATc/–ATc) TnSeq Gene Essentiality Predictions (1, 2) Essential Growth Defect Non-Essential Growth Advantage Unknown Operon Legend (3) Operon TSS Legend ? Ju, 2024 (5) Li, 2017 (4) (1) PMID: 28096490 (2) PMID: 31388080 (3) PMID: 26536359 (4) PMID: 29326668 (5) PMID: 38418874 MSMEG3751 MSMEG3752 MSMEG3753 MSMEG3754 rrfA rrlA rrsA tyrS
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>ms3756_rrlA_dna
TGGCGCCGGCTTGGTGCACAGCAAACGTTGAGATGCGGTGTGGGAAACGCTGTTTCGATGGACTGCCAGACACACTATTGGGCCCTGAGACAACAGGCCCGTTGTTCCCTGGCCACTGTGTGTGGTGGGAGGCGTGTTGTTGCCCTGCTTTGGTGGTGGGGTGTGGTGTTTGATTTGTGGATAGTGGTTGCGAGCATCTAGTTCGTAAGAGTGTGGCTGCCGGCCTTTGAGGTTGGGTGGCGCATTGTTGCGGACAAATTGATGTGCAATTTTTCTTCTGATTATTGGTTTTTTGTGTTGTAAGTGTTTAAGGGCGCATGGTGGATGCCTTGGCACTGGGAGCCGATGAAGGACGTAGGAGGCTGCGATAAGCCTCGGGGAGCTGTCAACCGAGCGTTGATCCGAGGATGTCCGAATGGGGAAACCCGGCACGAGTGATGTCGTGTCACCAGGCGCTGAATATATAGGCGTCTGGGGGGAACGCGGGGAAGTGAAACATCTCAGTACCCGTAGGAAGAGAAAACAAAATGTGATTCCGTGAGTAGTGGCGAGCGAAAGCGGAGGATGGCTAAACCGTATGCATGTGATACCGGGTAGGGGTTGTGTGTGCGGGGTTGTGGGACCTATCTTTCCGGCTCTACCTGGCTGGAGGGCAGTGAGAAAATGTTGTGGTTAGCGGAAATGGCTTGGGATGGCCTGCCGTAGACGGTGAGAGCCCGGTACGTGAAAACCCGACGTCTGTCTTGATGGTGTTCCCGAGTAGCAGCGGGCCCGTGGAATCTGCTGTGAATCTGCCGGGACCACCCGGTAAGCCTGAATACTTCCCAGTGACCGATAGCGGATTAGTACCGTGAGGGAATGGTGAAAAGTACCCCGGGAGGGGAGTGAAAGAGTACCTGAAACCGTGCGCTTACAATCCGTCAGAGCCCTCGACGTGTCGTGGGGTGATGGCGTGCCTTTTGAAGAATGAGCCTGCGAGTCAGGGACATGTCGCGAGGTTAACCCGGGTGGGGTAGCCGCAGCGAAAGCGAGTCTGAATAGGGCGTATCCACACAAGAGTGTGTGGTGTAGTGGTGTGTTCTGGACCCGAAGCGGAGTGATCTACCCATGGCCAGGGTGAAGCGCGGGTAAGACCGCGTGGAGGCCCGAACCCACTTAGGTTGAAGACTGAGGGGATGAGCTGTGGGTAGGGGTGAAAGGCCAATCAAACTCCGTGATAGCTGGTTCTCCCCGAAATGCATTTAGGTGCAGCGTCGCATGTTTCTTGCCGGAGGTAGAGCTACTGGATGGCCGATGGGCCCCACAGGGTTACTGACGTCAGCCAAACTCCGAATGCCGGTAAGTCCAAGAGTGCGGCAGTGGGACGGCGGGGGATAAGCTCCGTGCGTCGAGAGGGAAACAGCCCAGATCGCCGGCTAAGGCCCCTAAGCGTGTGCTAAGTGGAAAAGGATGTGCAGTCGCGAAGACAACCAGGAGGTTGGCTTAGAAGCAGCCACCCTTGAAAGAGTGCGTAATAGCTCACTGGTCAAGTGATTGTGCGCCGATAATGTAGCGGGGCTCAAGCACACCGCCGAAGCCGCGGCAGCCAACGTGTTGGCTGGGTAGGGGAGCGTCCTGCATCCGGTGAAGCCGCCGAGTGATCGAGTGGTGGAGGGTGTGGGAGTGAGAATGCAGGCATGAGTAGCGATTAGGCAAGTGAGAACCTTGCCCGCCGAAAGACCAAGGGTTCCTGGGCCAGGCCAGTCCGCCCAGGGTGAGTCGGGACCTAAGGCGAGGCCGACAGGCGTAGTCGATGGACAACGGGTTGATATTCCCGTACCCGTGTATGTGCGTCCATGATGAATCAGCGGTACTAACCATCCAAAACCACCGTGACCGCACCTTTCGGGGTGTGGCGTTGGTGGGGCTGCATGGGACCTTCGTTGGTAGTAGTCAAGCGATGGGGTGACGCAGGAAGGTAGCCGTACCGGTCAGTGGTAATACCGGGGTAAGCCTGTAGGGAGTCAGATAGGTAAATCCGTCTGGCATATATCCTGAGAGGTGATGCATAGCCGAGTGAGGCGAATTCGGTGATCCTATGCTGCCGAGAAAAGCCTCTAGCGAGGACATACACGGCCCGTACCCCAAACCAACACAGGTGGTCAGGTAGAGAATACTAAGGCGTACGAGTGAACTATGGTTAAGGAACTCGGCAAAATGCCCCCGTAACTTCGGGAGAAGGGGGACCCACATGGCGTGTAAGCCTTTACGGCCCAAGCGTGAGTGGGTGGCACAAACCAGTGAGAAGCGACTGTTTACTAAAAACACAGGTCCGTGCGAAGTCGCAAGACGATGTATACGGACTGACGCCTGCCCGGTGCTGGAAGGTTAAGAGGACCCGTTAACTCCCTTTGGGGGTGAAGCGGAGAATTTAAGCCCCAGTAAACGGCGGTGGTAACTATAACCATCCTAAGGTAGCGAAATTCCTTGTCGGGTAAGTTCCGACCTGCACGAATGGCGTAACGACTTCTCAACTGTCTCAACCATAGACTCGGCGAAATTGCACTACGAGTAAAGATGCTCGTTACGCGCGGCAGGACGAAAAGACCCCGGGACCTTCACTACAACTTGGTATTGGTGCTCGATACGGTTTGTGTAGGATAGGTGGGAGACTGTGAAGCTCACACGCCAGTGTGGGTGGAGTCGTTGTTGAAATACCACTCTGATCGTATTGGGCCTCTAACCTCGGACCGTATATCCGGTTCAGGGACAGTGCCTGGTGGGTAGTTTAACTGGGGCGGTTGCCTCCTAAAATGTAACGGAGGCGCCCAAAGGTTCCCTCAACCTGGACGGCAATCAGGTGTTGAGTGTAAGTGCACAAGGGAGCTTGACTGCGAGACGGACATGTCGAGCAGGGACGAAAGTCGGGACTAGTGATCCGGCACCTCTGAGTGGAAGGGGTGTCGCTCAACGGATAAAAGGTACCCCGGGGATAACAGGCTGATCTTCCCCAAGAGTCCATATCGACGGGATGGTTTGGCACCTCGATGTCGGCTCGTCGCATCCTGGGGCTGGAGCAGGTCCCAAGGGTTGGGCTGTTCGCCCATTAAAGCGGCACGCGAGCTGGGTTTAGAACGTCGTGAGACAGTTCGGTCTCTATCCGCCGCGCGCGTCAGAAGCTTGAGGAAACCTGTCCCTAGTACGAGAGGACCGGGACGGACGAACCTCTGGTATACCAGTTGTCCCACCAGGGGCACGGCTGGATAGCCACGTTCGGACAGGATAACCGCTGAAAGCATCTAAGCGGGAAACCTCTTCCAAGACCAGGCTTCTCACCCTCTAGGAGGGATAAGGCCCCCCGCAGACCACGGGATTGATAGACCAGACCTGGAAGCCTAGTAATAGGTGCAGGGAACTGGCACTAACCGGCCGAAAACTTAC

Protein Sequence 

>Ms3756_RrlA_protein
VFKGAWWMPWHWEPMKDVGGCDKPRGAVNRALIRGCPNGETRHE_CRVTRR_IYRRLGGTRGSETSQYP_EEKTKCDSVSSGERKRRMAKPYACDTG_GLCVRGCGTYLSGSTWLEGSEKMLWLAEMAWDGLP_TVRARYVKTRRLS_WCSRVAAGPWNLL_ICRDHPVSLNTSQ_PIAD_YREGMVKSTPGGE_KST_NRALTIRQSPRRVVG_WRAF_RMSLRVRDMSRG_PGWGSRSESESE_GVSTQECVV_WCVLDPKRSDLPMARVKRG_DRVEARTHLG_RLRG_AVGRGERPIKLRDSWFSPKCI_VQRRMFLAGGRATGWPMGPTGLLTSAKLRMPVSPRVRQWDGGG_APCVERETAQIAG_GP_ACAKWKRMCSREDNQEVGLEAATLERVRNSSLVK_LCADNVAGLKHTAEAAAANVLAG_GSVLHPVKPPSDRVVEGVGVRMQA_VAIRQVRTLPAERPRVPGPGQSAQGESGPKARPTGVVDGQRVDIPVPVYVRP__ISGTNHPKPP_PHLSGCGVGGAAWDLRW__SSDGVTQEGSRTGQW_YRGKPVGSQIGKSVWHIS_EVMHSRVRRIR_SYAAEKSL_RGHTRPVPQTNTGGQVENTKAYE_TMVKELGKMPP_LREKGDPHGV_AFTAQA_VGGTNQ_EATVY_KHRSVRSRKTMYTD_RLPGAGRLRGPVNSLWG_SGEFKPQ_TAVVTITILR_RNSLSGKFRPARMA_RLLNCLNHRLGEIALRVKMLVTRGRTKRPRDLHYNLVLVLDTVCVG_VGDCEAHTPVWVESLLKYHSDRIGPLTSDRISGSGTVPGG_FNWGGCLLKCNGGAQRFPQPGRQSGVECKCTRELDCETDMSSRDESRD__SGTSEWKGCRSTDKRYPGDNRLIFPKSPYRRDGLAPRCRLVASWGWSRSQGLGCSPIKAARELGLERRETVRSLSAARVRSLRKPVPSTRGPGRTNLWYTSCPTRGTAG_PRSDRITAESI_AGNLFQDQASHPLGGIRPPADHGIDRPDLEA___VQGTGTNRPKTY

Essentiality:

Call Condition Type Source Notes
Unknown in vitro CRISPRi [Bosch & DeJesus et al. (2021)]
Unknown in vitro TnSeq [Dragset et al. (2019)]

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