pknA
mL0017c
Probable transmembrane serine/threonine-protein kinase A PknA (protein kinase A) (STPK A)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 20879 – 22192
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL0017c_pknA_dna
ATGAGTCCGCGAATTGGTGTGATGCTGTCTGGTAGATACCGCCTGCATCGGCTCATCGCCACCGGTGGCATGGGCCAAGTATGGGAAGCGGTGGACAGTCGGCTGGGTCGCCGCGTTGCGGTCAAGGTGCTCAAGGGAGAGTTCTCCTCGGACCCGGAGTTCATTGAGCGGTTCCGCGCTGAGGCACGAACCACCGCGATGCTCAACCACCCCGGAATCGCCAGCGTCCATGACTACGGCGAAAGCCATATGGACGGGGAGGGCCGCACAGCCTACTTGGTGATGGAACTGGTCAACGGCGAACCACTGAATTCGGTGCTTAAACGCACCGGCCGGCTGTCGTTGCGGCATGCGCTGGACATGCTGGAGCAGACTGGCCGTGCCCTGCAAATTGCTCATGCCGCTGGCCTGGTACACCGCGACGTCAAACCGGGAAACATCTTAATCACCCCCACCGGCCAGGTGAAAATCACTGACTTCGGTATCGCCAAGGCAGTCGACGCTGCACCAGTGACCCAAACCGGCATGGTTATGGGCACCGCGCAATACATCGCGCCCGAACAGGCCTTAGGTCACGACGCGACTCCTGCTAGCGATGTCTACTCGTTGGGAGTTATTGGGTATGAAGTGGTTTCGGGTAAGCGGCCGTTCACCGGTGACGGCGCCCTAACGGTAGCGATGAAGCACATCAAGGAACCCCCGCCGCCGTTGCCCGCGGACTTACCGCCTAATGTACGAGAACTCATCGAGATCACATTGGTGAAAAACCCGGGCATGCGCTATCCTAGTGGAGGATTGTTCGCCGAAGCCGTCGCCGCGGTACGGGCCGGCCATCGGCCCCCGCGGCCCAACCAAACACCATCTTCCGGCCGGGCCTCTCCAACGACCATCCCGTCAAGCACACAGGCCCGAGCAGCTGTTGCTTGCGGCACCAAGACTCCGGCACCTCGCCGATCCCGACCGTCAACAAGCGGAAATCGCCCGCCGCCGGCGCGAAACACGTTCTCGTCTGGACAACGCGCGTTGCTCTGGGCCGCCGGGATGCTCGGAGCGCTGGCGATCATCATCGCGGTGCTGATCGTGATCAACTCCTACGCTGGAAACGAACAGCATCAACCGCCTACTCCAACCGTTACTGACACCGGTACGCCACCAGCTACCAAAACCCTCAGCGGTTTTCCGGCTGCATATTGCGAATACCGAGTCAACTGGACGAATCACAAAGAAATAAGTAATTCTGGACTTCCAAAGCAGGCCGCTCGAGCTCAACTGGCCGGTGCCACTGACATCTCGCCCGTCGCCGGCCAAACATGA

Protein Sequence 

>ML0017c_PknA_protein
MSPRIGVMLSGRYRLHRLIATGGMGQVWEAVDSRLGRRVAVKVLKGEFSSDPEFIERFRAEARTTAMLNHPGIASVHDYGESHMDGEGRTAYLVMELVNGEPLNSVLKRTGRLSLRHALDMLEQTGRALQIAHAAGLVHRDVKPGNILITPTGQVKITDFGIAKAVDAAPVTQTGMVMGTAQYIAPEQALGHDATPASDVYSLGVIGYEVVSGKRPFTGDGALTVAMKHIKEPPPPLPADLPPNVRELIEITLVKNPGMRYPSGGLFAEAVAAVRAGHRPPRPNQTPSSGRASPTTIPSSTQARAAVACGTKTPAPRRSRPSTSGNRPPPARNTFSSGQRALLWAAGMLGALAIIIAVLIVINSYAGNEQHQPPTPTVTDTGTPPATKTLSGFPAAYCEYRVNWTNHKEISNSGLPKQAARAQLAGATDISPVAGQT

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding PknA with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

10 show intermediate predicted evidence for PPIs

69 show weak predicted evidence for PPIs

View all pooled AlphaFold results for PknA

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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