espI
mL0048c
ESX-1 SECRETION-ASSOCIATED PROTEIN ESPI. CONSERVED PROLINE AND ALANINE RICH PROTEIN.
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 59555 – 61315
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL0048c_espI_dna
ATGGCGGCCGATTATGACAAACTCTTTCGGCTTGACGATGGTGCCTACGCATCGCCAGATCAGGCAGCGGAGCAGTTATTCGACGATGCTCCACTATATCCGCCACCCATCATACCAACCTGTACTACGACGCCCAATGGTGAAGTTGCGTCCCCAATGCCGGATTGGTCAGAGCAGCTGCCGCCGAACCCCCCGGCTGCATCCAAATCTCCTCTGCCCCCGATGCCCATCGGCAGCTCGGTGCAACCCCCGCCGGCCTCATCCGAATCTCCGCGGGCCCCTATGCCAGTTAGCGCCCCTCCCCGTTCGCCAGCAGCATCGTTAATGCCAATCAGCGAACCTCCGCAATGGCCACCCGCGGAGGCACCCGAACATCAATTTGCTAAAGCCGAGCCCCCATCGGTCCCGATACCGATCAACGAGCCTTCCCCGGCCAAACCTGCAACGCCAATGCCGATGACGCCAATCGACGGATCCCAGCGAACGCCGGTCACCTCGCCTGAACCTTCTCTTGCTGAATTCGAAGCACAGCCTCCGGCTACACCCAAACCATCTTTGCTTCCGAGGCCAATGAGCAGTCCGCCTGAAGCGCCGCGTCCATCTGCGAACCAACATTCACGACACGCTCGCCGGGGTCACCACCATCGCGACGAAACCCAACAGGCCAACCCGGCATCAGCAACTGAGCCTATGATCGCGCCGCGCGCGAGGACAGCTGAACTGCGGCAGGCGCCCCACGCCGCAGCAGAGCCGGCTCCGACACAACATCTTACCAGACCTGATGGCCTGGTAAGTCACCGTACCGCACTGCACGATTCGACTGCGACATCCGCAATCGGCGTGCAGACAGGACGGAGCACCGGGGCCAAAAAGCCGAGCAAGGTGGTGGCTAAACGAGGGTGGCGGCATTGGGTCCATACCGTGACGCGGATAAACCTGGGCCTGTCACCAGACGAGCGCTACGAGCTGGATTTGCGCACGCGGGTACGTCGACCGCCCCGCGGTTCGTATCAGATCGGGATCTTGGGCCTCAAAGGCGGGGCCGGTAAGACGACCGTGACGGTTACTTTGGGCTCGATGTTCGCTCGGGTGCGTAACGACCGGATTCTGGTAGTTGACGCAGATACCAGCTGCGGAAACCTCGCCGACCGAGCGGGACGTTTTTCGGAAGCAAACATCGCTGATCTGCTGGCAGACAAAGATGTGAAGTCCTACAACGATATCCGCACGCACACCAGCGTAAATGCAGTCAATCTTGAAGTTCTCCCCGCAGCGGAATACAGCACAGCCCAACACGCCCTGAGCGGAGAGGACTGGAATTTCGCTGCCGCGACAGTATCAAAGTACTACAATGTAATGTTGGCCGACTGCGGGGTCGGTTTGTTCGACCCGGTCACCCGCGGTGTGCTCTCGACAGCGTCCGGGGTGGTGATCGTTACCAGCACGTCGGTCGACGCCGCCCGGCAAGCTGCGATTGCCTTGGACTGGCTACGCCATAACGGTTATCAAGACTTATTGAGTCGTGCATGTGTGGTGATTAACCACGTCATGCCGAAAGAGCCCAACATCGCTAGCAAAGATTTAGTGCAACAATTCGAACAACAAATTCAACCCGGCCGGGTTGTGGTACTGCCTTGGGACAAGCACATCGCAGCCGGAACCGAAATTCGACTCGACCGGCTCGACCCCCTCTACCGGCGCCGGATCCTCGAACTGGCCGCAGCACTGTCCGACGATTTTGAGAGAGCTGGACGTCATTGA

Protein Sequence 

>ML0048c_EspI_protein
MAADYDKLFRLDDGAYASPDQAAEQLFDDAPLYPPPIIPTCTTTPNGEVASPMPDWSEQLPPNPPAASKSPLPPMPIGSSVQPPPASSESPRAPMPVSAPPRSPAASLMPISEPPQWPPAEAPEHQFAKAEPPSVPIPINEPSPAKPATPMPMTPIDGSQRTPVTSPEPSLAEFEAQPPATPKPSLLPRPMSSPPEAPRPSANQHSRHARRGHHHRDETQQANPASATEPMIAPRARTAELRQAPHAAAEPAPTQHLTRPDGLVSHRTALHDSTATSAIGVQTGRSTGAKKPSKVVAKRGWRHWVHTVTRINLGLSPDERYELDLRTRVRRPPRGSYQIGILGLKGGAGKTTVTVTLGSMFARVRNDRILVVDADTSCGNLADRAGRFSEANIADLLADKDVKSYNDIRTHTSVNAVNLEVLPAAEYSTAQHALSGEDWNFAAATVSKYYNVMLADCGVGLFDPVTRGVLSTASGVVIVTSTSVDAARQAAIALDWLRHNGYQDLLSRACVVINHVMPKEPNIASKDLVQQFEQQIQPGRVVVLPWDKHIAAGTEIRLDRLDPLYRRRILELAAALSDDFERAGRH

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding EspI with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

2 show intermediate predicted evidence for PPIs

16 show weak predicted evidence for PPIs

View all pooled AlphaFold results for EspI

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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