esxA
mL0049c
Probable 6 kDa early secretory antigenic target homolog EsxA (ESAT-6-like protein) (L-ESAT)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 61406 – 61693
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL0049c_esxA_dna
ATGATACAGGCGTGGCACTTTCCTGCCCTACAGGGTGCCGTCAACGAACTGCAAGGAAGCCAGAGCAGAATCGATGCGTTGCTCGAGCAATGCCAAGAATCGCTCACAAAGCTGCAGAGCTCGTGGCATGGTTCCGGTAACGAGTCCTATTCGTCAGTCCAACGACGTTTCAACCAGAACACCGAGGGAATAAACCATGCACTGGGCGACCTGGTGCAAGCAATCAATCACTCGGCTGAAACGATGCAACAGACCGAGGCAGGCGTCATGAGTATGTTCACCGGGTAG

Protein Sequence 

>ML0049c_EsxA_protein
MIQAWHFPALQGAVNELQGSQSRIDALLEQCQESLTKLQSSWHGSGNESYSSVQRRFNQNTEGINHALGDLVQAINHSAETMQQTEAGVMSMFTG

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding EsxA with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

3 show intermediate predicted evidence for PPIs

27 show weak predicted evidence for PPIs

View all pooled AlphaFold results for EsxA

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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