mscL
mL0178c
Possible large-conductance ion mechanosensitive channel MscL
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 244787 – 245251
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL0178c_mscL_dna
ATGTTCAGAGGGTTCAAGGAGTTTCTCTCACGAGGCAATATCGTCGACCTGGCCGTAGCGGTGGTTATCGGTACCGCGTTCACCGCGTTGATAACCAAGTTCACCGACAGCATCATCACGCCATTGATCAATCGGGTCGGCGTCAACCAACAAACCAATATCAGCCCCTTGAGGATCGACATAGGGGGAGATCAGGCCATCGACTTGAACATCGTGCTCTCGGCCGCGATCAACTTCTTGCTGATCGCTTTGGTAGTGTATTTCCTGGTCGTGTTGCCCTACACCACGATACGCAAGCATGGTGAGGTCGAACAATTCGACACCGACCTAATCGGGAACCAAGTTGTCCTACTCGCCGAAATCCGTGATCTTCTCGCCCAAAGTAACGGGGCTCCGTCCGGCAGGCACGTCGATACAGCCGATCTGACGCCAACCCCAAACCACGAACCTCGCGCAGACACATGA

Protein Sequence 

>ML0178c_MscL_protein
MFRGFKEFLSRGNIVDLAVAVVIGTAFTALITKFTDSIITPLINRVGVNQQTNISPLRIDIGGDQAIDLNIVLSAAINFLLIALVVYFLVVLPYTTIRKHGEVEQFDTDLIGNQVVLLAEIRDLLAQSNGAPSGRHVDTADLTPTPNHEPRADT

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding MscL with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

0 show intermediate predicted evidence for PPIs

19 show weak predicted evidence for PPIs

View all pooled AlphaFold results for MscL

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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