hpt
mL0214
Probable hypoxanthine-guanine phosphoribosyltransferase Hpt (HGPRT) (HGPRTase) (hypoxanthine phosphoribosyltransferase) (IMP phosphoribosyltransferase) (IMP diphosphorylase) (transphosphoribosyltransferase) (guanine phosphoribosyltransferase)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 285584 – 286225
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL0214_hpt_dna
GTGGTTTTTCGCAGGGCAGCATGGCACGCTTTGCTCGTGGCCCAGAGCTTCTCGGCGATTAACCCCGGACCGACGGCAGAGTTGTACCTGGGTGATATCAAGTCGGTCATGCTCACCCAGGAGCAGATTCAGGCTAGGATTGCCGAGCTCGGCGCCCAAATCGGCCACGACTATCGTGACCGTTCGCCTGCTAGTGACCAGGATCTGCTGTTGGTCACCGTGCTTAAGGGAGCGGTGATCTTCGTCACTGACCTGGCGCGTGCGATTCCACTGCCAACTCAGTTCGAATTCATGGCCGTTAGTTCGTATGGATCCTCGATGTCCTCGTCGGGTGTGGTGCGGATTCTCAAGGATCTTGATCGCGATATCCACGATCGCAACGTGTTGATAGTCGAGGACGTCGTGGATTCAGGTCTGACCTTGTCTTGGTTGCTGCGGAACTTGGCAACCCGTCGTCCGCAGTCGTTGCAGGTGTGCACGCTGCTGCGCAAGCCCGATGCGCTACGTGCCAATGTCGATATCACTTATGTGGGTTTCGACATTCCCAACGACTTCGTCGTGGGCTATGGACTGGATTACGACGAGCGTTACCGTGACCTGCCCTATATCGGTATGCTGGATCCCCGTGTCTACCAGCAATAG

Protein Sequence 

>ML0214_Hpt_protein
VVFRRAAWHALLVAQSFSAINPGPTAELYLGDIKSVMLTQEQIQARIAELGAQIGHDYRDRSPASDQDLLLVTVLKGAVIFVTDLARAIPLPTQFEFMAVSSYGSSMSSSGVVRILKDLDRDIHDRNVLIVEDVVDSGLTLSWLLRNLATRRPQSLQVCTLLRKPDALRANVDITYVGFDIPNDFVVGYGLDYDERYRDLPYIGMLDPRVYQQ

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding Hpt with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

1 shows intermediate predicted evidence for PPIs

18 show weak predicted evidence for PPIs

View all pooled AlphaFold results for Hpt

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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