ftsH
mL0222
Probable membrane-bound protease FtsH (cell division protein)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 293693 – 296065
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL0222_ftsH_dna
ATGTTATTGATGAACCGAAAAAACGTTATCCGCATGGTTACGGCGATCGCTGTAGTGGTGCTGCTCGGCTGGTCGTTTTTCTACTTCAGCGACGACACTCGTGGTTACAAGTTCGTCGACACCTCGGTGGCGATGTCCCAGATCAACGGCCACAACGTCAAGAGCGCGCAAATTGATGACCGGGAACAGCAGCTGCGGTTGACCTTGAAGAAGGGCAACAACGACACCGATGGCTCTGACAAGGTCATAACCAAATACCCCACCGGGTACGCGGTCGATTTGTTCAACGCGCTGAGCGCTAAGAACACGAAGGTCACCACCGCCGTAAACGAAGGCAGCATCCTGGGCGAGTTGCTCGTTTATGTGCTGCCATTGCTTTTGCTGGTGGGCCTGTTTGTGATGTTCTCTCGTATGCAGGGCGGCGCTCGAATGGGCTTTGGATTCGGCAAATCACGCGCTAAGCAACTTTCCAAAGACATGCCCAAGACCACTTTCGCTGACGTTGCCGGTGTTGACGAGGCGGTCGAGGAGCTCTACGAGATCAAGGACTTCTTGCAAAACCCCTGTAGGTACCAGACGCTCGGCGCGAAGATCCCCAAGGGCGTGCTGCTCTACGGGCCGCCGGGCACCGGTAAAACGTTGCTGGCCCGCGCTGTGGCGGGAGAGGCAGGCGTTCCGTTCTTCACCATCTCCGGATCCGACTTCGTCGAGATGTTCGTTGGCGTTGGCGCTTCACGCGTAAGGGACCTGTTCGACCAGGCTAAGCAGAACAGCCCGTGCATCATCTTTGTCGATGAGATAGACGCGGTGGGCCGCCAGCGCGGCACCGGGCTCGGCGGTGGCCACGACGAGCGCGAGCAAACACTGAACCAGTTGCTGGTCGAGATGGACGGTTTTGGCGATCGGGCGGGCGTCATCTTGATCGCGGCAACCAACCGGCCTGACATCTTGGACCCCGCGCTTCTAAGGCCCGGGCGTTTCGACCGGCAGATCCCGGTGTCCAACCCGGACCTGGCAGGTCGTCGCGCGGTGCTGCGCGTGCATTCGAAGGGCAAGCCGATTGCCGACGATGCTGACCTCGACGGACTGGCCAAACGCACTGTCGGAATGACCGGCGCTGACCTTGCCAACGTTGTCAACGAGGCGGCGCTGCTGACCGCCCGAGAGAACGGCCTGGTGATTACCGGACCCGCCTTGGAGGAGGCGGTGGACCGGGTGATCGGCGGGCCACGTCGCAAGGGCCGGATCATCAGCGAGCAGGAAAAGAAAATCACAGCGTATCACGAGGGCGGGCACACCTTGGCGGCTTGGGCTATGCCTGATATCGAGCCTATCTACAAGGTGACGATCCTGGCTCGGGGACGTACCGGCGGGCACGCGGTGGCGGTGCCCGAGGAAGACAAGGGCTTGAGGACCCGCTCGGAAATGATCGCGCAGCTGGTGTTCGCGATGGGTGGACGTGCCGCCGAGGAGTTGGTGTTCCGCGAGCCGACGACCGGTGCGGTATCGGATATCGAGAAGGCCACCAAAATCGCGCGCTCGATGGTTACCGAATTCGGTATGAGCTCCAAACTTGGAGCGGTCAGATATGGTTCCGAGCACGGCGACCCGTTCCTCGGCCGGACCATGGGCACCCAGGCGGATTACTCTCATGAGGTCGCCCGCGACATCGATGATGAGGTTCGCAAGCTTATTGAAGCCGCGCACACCGAGGCGTGGGAGATTCTCACCGAATACCGCGACGTGCTTGACACCCTGGCCGGCGAGCTGCTGGAAAAAGAAACTCTGCACCGACCAGAGCTGGAGGGGATCTTCGCCAGCGTCGAAAAGCGACCCCGGCTCACCATGTTCGACGATTTTGGTGGGCGGATCCCGTCGGACAAGCCGCCGATCAAGACACCCGGCGAGCTGGCGATCGAGCGCGGCGAGCCCTGGCCCCAGCCAGTCCCCGAGCCGGCGTTCAAGGCAGCCATCGCCCGTGCTTCGCAGGCCGCTGAGGCCTCGCACCAAGCAGCACAATCGGATACCGATGGGCCCCCCGGCCAGGGGGCCAATGGTTCACATGCCGGGGACCGTCAGCGCCAGCACGGCCCTACTCAACCCGACTATGGCGCTCCGCCGGGTTGGCATGCGCCTGGATGGCCGCCACAACAGCCGCCGGATTACTGGTATCCGCCTGAACAGCAACCCTCACAGTCGCCCTATTGGCCGCAGCCCGCGCCCAGCTATCCGGGCCAAGCCCCCCCTCCGTATCCGTCGTACCCGCCTTGTCCTTCTTACCCGCCGCCTGGTCAATCCGCCCCGGACGCGGGTAAGCCCCCTGCACAGTTGGACGAGGGCGTGAGCCCCTCCAACCCACCGGCGCACGGCTGA

Protein Sequence 

>ML0222_FtsH_protein
MLLMNRKNVIRMVTAIAVVVLLGWSFFYFSDDTRGYKFVDTSVAMSQINGHNVKSAQIDDREQQLRLTLKKGNNDTDGSDKVITKYPTGYAVDLFNALSAKNTKVTTAVNEGSILGELLVYVLPLLLLVGLFVMFSRMQGGARMGFGFGKSRAKQLSKDMPKTTFADVAGVDEAVEELYEIKDFLQNPCRYQTLGAKIPKGVLLYGPPGTGKTLLARAVAGEAGVPFFTISGSDFVEMFVGVGASRVRDLFDQAKQNSPCIIFVDEIDAVGRQRGTGLGGGHDEREQTLNQLLVEMDGFGDRAGVILIAATNRPDILDPALLRPGRFDRQIPVSNPDLAGRRAVLRVHSKGKPIADDADLDGLAKRTVGMTGADLANVVNEAALLTARENGLVITGPALEEAVDRVIGGPRRKGRIISEQEKKITAYHEGGHTLAAWAMPDIEPIYKVTILARGRTGGHAVAVPEEDKGLRTRSEMIAQLVFAMGGRAAEELVFREPTTGAVSDIEKATKIARSMVTEFGMSSKLGAVRYGSEHGDPFLGRTMGTQADYSHEVARDIDDEVRKLIEAAHTEAWEILTEYRDVLDTLAGELLEKETLHRPELEGIFASVEKRPRLTMFDDFGGRIPSDKPPIKTPGELAIERGEPWPQPVPEPAFKAAIARASQAAEASHQAAQSDTDGPPGQGANGSHAGDRQRQHGPTQPDYGAPPGWHAPGWPPQQPPDYWYPPEQQPSQSPYWPQPAPSYPGQAPPPYPSYPPCPSYPPPGQSAPDAGKPPAQLDEGVSPSNPPAHG

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding FtsH with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

2 show intermediate predicted evidence for PPIs

78 show weak predicted evidence for PPIs

View all pooled AlphaFold results for FtsH

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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