folK
mL0226
Probable2-amino-4-hydroxy-6-hydroxymethyldihydropterine pyrophosphokinase FolK (7%2C8-dihydro-6-hydroxymethylpterin-pyrophosphokinase) (HPPK) (6-hydroxymethyl-7%2C8-dihydropterin pyrophosphokinase) (PPPK) (2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase) (7%2C8-dihydro-6-hydroxymethylpterin-diphosphokinase) (6-hydroxymethyl-7%2C8-dihydropterin diphosphokinase)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 297941 – 298516
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL0226_folK_dna
ATGACTCGCGTCGTACTGTCTATAGGATCCAATCTGGGTGACCGGCTGGCGTGGCTGCAGTCAGCCGTCGATGGGCTGGGTGATGCGGTTGTCGCGGTCTCTCCGGTGTATGACACCGTCCCGTGGGGAGCCGTGGAGCAGAGATCGTTCCTCAACGCGGTAGTGATCGCCGACGGCCCGGCGTATGACACGAAGGCCTGGCTGTGTCGGGCTCAGGAGCTCGAGCGGAACGCGGGTCGGGTGCGGGGACAGCGCTGGGGCGCACGCACACTCGACGTCGATCTGATCTCCTGCTATCAGACTTCGGGTGCTACGACCGGTGCGGTCGAGGTGATTACGTGCGAAAGCAACTTGACGTTGCCGCATCCGCGGGCTCATCTGCGGGCTTTCGTGCTGGTTCCGTGGTTGGCTGTCGACTCGGATGCTGAGCTGACCGTCGCTGGGCGGGCGCAACGGGTCGATCGGCTGTTGGCAGAGATGGAGCCGACCGAGCGGGAAGGTGTGCGGTTGACCAATCTGACGCTCAAGCTGAAACGTAGTTCGCCGGCGCGGCCAGTCAGTCCGAAATCAGACTGA

Protein Sequence 

>ML0226_FolK_protein
MTRVVLSIGSNLGDRLAWLQSAVDGLGDAVVAVSPVYDTVPWGAVEQRSFLNAVVIADGPAYDTKAWLCRAQELERNAGRVRGQRWGARTLDVDLISCYQTSGATTGAVEVITCESNLTLPHPRAHLRAFVLVPWLAVDSDAELTVAGRAQRVDRLLAEMEPTEREGVRLTNLTLKLKRSSPARPVSPKSD

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding FolK with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

0 show intermediate predicted evidence for PPIs

15 show weak predicted evidence for PPIs

View all pooled AlphaFold results for FolK

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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