ksgA
mL0241
Probable dimethyladenosine transferase KsgA (S-adenosylmethionine-6-N'%2C N'-adenosyl(rRNA) dimethyltransferase) (16S rRNA dimethylase) (High level kasugamycin resistance protein ksgA) (Kasugamycin dimethyltransferase)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 316048 – 316968
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL0241_ksgA_dna
GTGCAGCGGAAGAGTGGGTGCACACTGACCATCCGGCTACTCGAGCGTACCGAGATCAGGTGGCTGGTAAAAGAACTTGAATGTCGGCCACGGAAATCTCTCGGCCAAAATTTCGTGCACGACGCCAACACGGTGCGACGTGTGGTTTCGACTTCCAGAGTGAACCGGTCTGACTTCGTCTTGGAGGTTGGTCCTGGCTTCGGATCGCTCACGCTGGCATTGCTGGACTGCGGCGCTGCCGTCAGTGCCATAGAAATTGACCCAGTGTTAGCGGGTCGGTTGCCGCAGACGGTTGCTGAGCATTCAAATAATGAGATCCACCGGCTCACGGTGTGCAACCGCGACGTTTTATCCTTTCGCCGTGGCGATCTGGCTACCGAGCCGACGGCGCTAGTTGCCAACCTGCCGTACAACGTTGCGGTTCCGGCGTTATTGCATCTGCTCGCCGAGTTCCCGTCCATCAGGACTGTTACGGTGATGGTGCAGGCTGAGGTCGCCGAACGGCTTGCCGCCGAGCCGGGTGGCAAGGATTACGGCGTGCCCAGCGTCAAGTTGAGTTTCTTTGGACGGGTCCGTCGCTGTGGCATGGTGTCTCCGACTGTTTTCTGGCCGATTCCTCGTGTCTACTCCGGTTTGGTACGCGTCGACCGCTATGCGACTTCGCCATGGCCGACTGATGACGCCTTCCGTCGGCAGGTATTCGAACTGGTAGACATTGCATTCACTCAGCGGCGCAAGACATCTCGCAACGCGTTTGTGAAGTGGGCGGGTTCGAGTAACGAATCAGCGAATCGATTGCTTGCCGCTAGCATCGATCCTGCCCGTCGCGGCGAGACGCTGTCCATCGACGACTTCGTTCGACTGCTGCGACGTTCTGATGGTCGAGACGACGCGGCGGTGCGGTCTGCTTCGGCGAGCTGA

Protein Sequence 

>ML0241_KsgA_protein
VQRKSGCTLTIRLLERTEIRWLVKELECRPRKSLGQNFVHDANTVRRVVSTSRVNRSDFVLEVGPGFGSLTLALLDCGAAVSAIEIDPVLAGRLPQTVAEHSNNEIHRLTVCNRDVLSFRRGDLATEPTALVANLPYNVAVPALLHLLAEFPSIRTVTVMVQAEVAERLAAEPGGKDYGVPSVKLSFFGRVRRCGMVSPTVFWPIPRVYSGLVRVDRYATSPWPTDDAFRRQVFELVDIAFTQRRKTSRNAFVKWAGSSNESANRLLAASIDPARRGETLSIDDFVRLLRRSDGRDDAAVRSASAS

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding KsgA with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

2 show intermediate predicted evidence for PPIs

25 show weak predicted evidence for PPIs

View all pooled AlphaFold results for KsgA

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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