mfd
mL0252
Probable transcription-repair coupling factor Mfd (trcF)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 328067 – 331741
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL0252_mfd_dna
ATGACCGCACCGGGGCCTGCTTGCCTAGACACCCCAATCGCGGGGCTCGTTGAATTGGCACTCACTGCGCCGACCTTCGGCCAGCTCATGGAGCGCGCGGGCACTAGACCAGCTGAATTGATCCTGGCTGGCCCTGCCTGTGCGCGGTTGTTCGTCGCCAGTGCGCTGGCTAGGCTGGGTCCCTTGCTGGTGGTTACCGCCACCGGTCGTGAAGCGAGCAATCTTACCGCAGAGCTGCGCGGTGTCTTCGGCGCCGCGGTGGCGATGTTCCCGTCCTGGGAGACGCTGCCGCACGAACGACTTTCACCTGGTGTAGACACCGTCGGTGCCCGGCTGATGGTGCTGCGCCGACTAGCCCATCCCGACGATGCCCGGTTGGGTCCACCCTTGCAGGTGGTGGTGACCGCGGTGCGTTCGCTGCTGCAGCCGATGACAGCGCAGCTGGGTTTGGTGGAACCTGTTACCTTGAGCGTTGGCGATGAGATCGGTTTTGAACGGGTTATCGCGCGCCTGGTCGAGCTGGCATATACCCGGGTAGATATGGTCGGCCGGCGCGGCGAGTTCGCCGTCCGCGGTGGGATTCTCGATATTTTCGGCCCGACTGCCGAACATCCGGTGCGTGTCGAATTCTGGGGTGACGAGATTACCGAGATGCGGATGTTTTCGGTGGTCGATCAGCGCTCTATTCCCGAGATCGGTGTTGACACGTTGGTTGCGATAGCCTGCCGGGAACTGCTGCTCAGCGACGACGTGCGAGCTCGGGCTGTCGAGTTGGCCGCGCAGGCGGCTGCACGGCGACCGACAGAGGAACCTGCCATCTCCGGCAGCGTCACTGACGTGTTGGCCAAGCTAGCCGAAGGGATACCAGTCGACGGGATGGAGGCTCTACTCCCGGTACTTTGTCCTGACGATTATGCGCTGCTGACTGACCAGTTCGCTGCTGACACGCCGGTGTTGCTGTGTGACCCGGAAAAGGTCCGCATTCAGGCCGCCGATTTGATCAAGACCGATCGAGCATTCCTCGAGGCGTCGTGGTCGGTTGCCGCCATAGGTGCAGACAACGCGGCACCCGTCGATGTCGAGCAGCTGTACGGGTCGGGGTTCGTAGAATTAGGCGACGTGCAGGCCGCCGCCATCCGGTCCGGTCATCCGTGGTGGACCTTGAGCCAACTGTCCGACGAGTCGGCTTTGGAGCTCGACATCCGGGCGGCACCGTCGACGCGTGGGCATCAGCATGCCATCGACGGCATTTTTGCGATGCTGCGTGCGCATGTTGCCACCGGTGGATATGCGGCGATCGTCACGCCTGGGACCGGAACCGCCCATCGAGTGGTGGAGCGACTTGCCGAGTCTGACATTCCGGGTGCGATGCTGGAACCGGCTGCCGCCCCCGGACTTGGCCTGCGACCAGGCCTGGTCGGGGTGCTCAAAGGTCCGCTGCTTGATGGTGTGGTTATACCGGGCGCCAACCTGGTGATCATCACCGAAGCCGATCTGACCGGCAGCCGAGCGACGCCTGTCGAGGGCAAGCGGCTGGCGGCCAAGCGGCGCAGCGCCGCCGATCCGTTGGCACTTACCGCTGGTGACTTGGTGGTGCATGATCAGCACGGCATCGGACGGTTCGTGGAAATGGTTGAGCGCACCGTTGGCGGTGCTCGTCGCGAGTACCTGGTGCTGGAATATGCCTCGAATAAGAAAAGTAAGCAGGCCGACAAGCTGTATGTTCCGATGGATTCGCTGGATCAGTTGTCACGGTATGTAGGCGGGCAAGCGCCGGCGCTTAGCCGGCTCGGCGGCAGCGACTGGGCTAATACCAAGACCAAGGCCCGCTGCGCGGTGCGAGAAATTGCGGGTGAATTGGTGTCGCTATACGCCAAACGCCAGGCCAGCCCCGGACACGCATTCGGGCCGGACACGCCCTGGCAGGCCGAGATGGAGGACGCGTTTGGCTTCACCGAGACCGTCGACCAGCTCACCGCGATCACCGAGGTCAAGGGCGATATGGAAAAGTCGGTGCCGATGGACCGAGTGATCTGCGGTGACGTTGGTTACGGCAAGGCCGAGATCGCGGTGCGTGCGGCGTTCAAGGCAGTGCAGGACGGCAAGCAGGTTGCCGTATTGGTACCGACCACATTGCTGGCCGACCAGCATCTGCGGACGTTCACCGAACGGATGGCCGGATTTCCGGTGACTGTCAAGGGGTTGTCACGGTTCACCGACGCCGCCGAGTCTCGCGCGGTGATCGACGGCCTTGCCGAGGGGTCGGTGGACATCGTGATCGGCACGCATCGGCTGCTGCAGACCGGGGTGTGCTGGAAGGATCTGGGTCTAGTCGTGGTTGACGAGGAACAGTGGTTCGGCGTCGAGCACAAGGAGCACATCAAGTCGCTGCGCACCCACGTCGACGTGCTGACCATGAGCGCCACCCCGATCCCGCGCACCCTAGAGATGAGCTTGGCTGGGATTCGCGAGATGTCGACGATCCTGACGCCGCCCGAAGAGCGCTACCCGGTTTTGACTTATGTAGGGCCGCACGATGACAAGCAGGTCGCGGCTGCGCTGCGGCGCGAACTTCTGCGCGATGGGCAGGCGTTTTATGTGCATAACCGGGTCAGCTCCATCTATCAGGCCGCTGCCCGGGTGTGTGGCTTGGTGCCCGAAGCGCGCGTGGTGGTCGCGCATGGGCAGATGCCCGAGGATCTGCTGGAAACCACCATGCGGGGGTTCTGGAACCGCGAATACGACATCTTAGTGTGCACCACGATCGTGGAGACCGGCTTGGACATCCCCAACGCCAACACGCTCGTCGTCGAGCGCGCCGATACCTTCGGTCTGTCTCAGCTGCACCAGCTGCGGGGTCGGGTCGGCCGTAGCCACGAGCGTGGTTACGCCTACTTCCTCTACCCGCCGCAGGCGCCGCTGACGGAGATCGCCTACGACCGGTTGGTGACCATCGCACAGAACAATGAGCTGGGAGCGGGCATGGCGGTCGCGCTCAAGGACCTAGAGATCCGCGGCGCCGGCAACGTGCTAGGTGTCGAGCAGTCCGGGCACGTAGCAGGGGTCGGATTCGACCTTTATGTGCGGCTGGTGGGTGAGGCCGTCGAGGCGTACCGAGCCGTTGCCGACGGCAAAACCGCCATTACTCCGGAGGAGCCGAAGGATGTACGGATCGACTTGCCGGTGGATGCACACCTGCCGCCAGATTACATCGCCAGTGATCGGCTCCGACTTGAAGGCTACCGGCGGTTGGCCGCGGCGTCTTCTGACACAGAGGTAGCGGCCGTTGTGGACGAGCTCATTGATCGCTACGGGGCACTGCCAGAGCCGGCCCAGCGGTTGGTGGCGGTGGCTCAGTTGCGGCTGCTGTGTCGAGGCTCGGGCATCATCGAAGTGACCGCCCCGTCGGCCTCTACCATGCGGTTGTCCCCAATTAGGCTGATAGATTCCGCCCAAGTGAGGTTAAAGCGGATGTATCCCGGAGCGCAGTACCGTGCTACCGCGGCCACGGTCCAGGTTCCTATACCGCGAGCCGGCAGCTCCGGGGGAACCTTAGGTGTCCCGTGTATCCGCGATGTGGAATTGGTTCAGGCGGTGGCTGACTTGATCACGGCGCTGCAGGGCCTACCGAGGAAGGTTATTGGCATAACGGGACCGGAACCGACATCGAAGTGA

Protein Sequence 

>ML0252_Mfd_protein
MTAPGPACLDTPIAGLVELALTAPTFGQLMERAGTRPAELILAGPACARLFVASALARLGPLLVVTATGREASNLTAELRGVFGAAVAMFPSWETLPHERLSPGVDTVGARLMVLRRLAHPDDARLGPPLQVVVTAVRSLLQPMTAQLGLVEPVTLSVGDEIGFERVIARLVELAYTRVDMVGRRGEFAVRGGILDIFGPTAEHPVRVEFWGDEITEMRMFSVVDQRSIPEIGVDTLVAIACRELLLSDDVRARAVELAAQAAARRPTEEPAISGSVTDVLAKLAEGIPVDGMEALLPVLCPDDYALLTDQFAADTPVLLCDPEKVRIQAADLIKTDRAFLEASWSVAAIGADNAAPVDVEQLYGSGFVELGDVQAAAIRSGHPWWTLSQLSDESALELDIRAAPSTRGHQHAIDGIFAMLRAHVATGGYAAIVTPGTGTAHRVVERLAESDIPGAMLEPAAAPGLGLRPGLVGVLKGPLLDGVVIPGANLVIITEADLTGSRATPVEGKRLAAKRRSAADPLALTAGDLVVHDQHGIGRFVEMVERTVGGARREYLVLEYASNKKSKQADKLYVPMDSLDQLSRYVGGQAPALSRLGGSDWANTKTKARCAVREIAGELVSLYAKRQASPGHAFGPDTPWQAEMEDAFGFTETVDQLTAITEVKGDMEKSVPMDRVICGDVGYGKAEIAVRAAFKAVQDGKQVAVLVPTTLLADQHLRTFTERMAGFPVTVKGLSRFTDAAESRAVIDGLAEGSVDIVIGTHRLLQTGVCWKDLGLVVVDEEQWFGVEHKEHIKSLRTHVDVLTMSATPIPRTLEMSLAGIREMSTILTPPEERYPVLTYVGPHDDKQVAAALRRELLRDGQAFYVHNRVSSIYQAAARVCGLVPEARVVVAHGQMPEDLLETTMRGFWNREYDILVCTTIVETGLDIPNANTLVVERADTFGLSQLHQLRGRVGRSHERGYAYFLYPPQAPLTEIAYDRLVTIAQNNELGAGMAVALKDLEIRGAGNVLGVEQSGHVAGVGFDLYVRLVGEAVEAYRAVADGKTAITPEEPKDVRIDLPVDAHLPPDYIASDRLRLEGYRRLAAASSDTEVAAVVDELIDRYGALPEPAQRLVAVAQLRLLCRGSGIIEVTAPSASTMRLSPIRLIDSAQVRLKRMYPGAQYRATAATVQVPIPRAGSSGGTLGVPCIRDVELVQAVADLITALQGLPRKVIGITGPEPTSK

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding Mfd with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

1 protein shows strong predicted evidence for PPIs

6 show intermediate predicted evidence for PPIs

55 show weak predicted evidence for PPIs

View all pooled AlphaFold results for Mfd

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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