purA
mL0280c
Probable adenylosuccinate synthase PurA (IMP--aspartate ligase) (AdSS) (AMPSase)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 361950 – 363248
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL0280c_purA_dna
ATGCCGGCAGTCGTCCTCATCGGCGCTCAGTGGGGCGACGAGGGCAAAGGTAAGGTCACAGACCTGCTCGGCGGACGTGCCCAGTGGGTGGTGCGCTATCAGGGTGGCAATAACGCTGGGCATACCGTTGTCTTGCCTACTGGCGAGAACTTCACACTGCATCTGATCCCGTCGGGGGTGCTGACGCCGGGTGTTACCAACGTCATCGGTAACGGTGTGGTGGTGGATCCCGGAGTGCTGCTCAGCGAACTGCAAGGCCTGGAAGATCGTGGTGTCGACACCTCCCAGCTGCTGATCTCAGCCGATGCGCACCTGCTGATGCCCTACCACGTGGCCATCGACAAGGTCACCGAGCGTTACATGGGCAACAAGAAGATCGGCACTACCGGCCGCGGTATCGGGCCCTGTTACCAGGACAAGATCGCCCGCATGGGGATACGGGTCGCCGATGTCTTAGAACCTGGTGAGTTGACCCACAAGATCGAGGCTGCGCTCGAGTTCAAAAACCAGGTGTTGGTCAAGATCTACAACCGCAAGGCGTTGGACCTGGCTCAGGTTGTCGAAACGCTGCTGGAGCAGGCGCAGCAATTTCGACATCGCATCACCGACACTCGTCTGTTGCTCAACGACGCCCTCGAGGCCGGTGAGACGGTGCTGCTTGAAGGCGCACAAGGCACCCTGCTCGACGTTGATCACGGCACCTACCCGTATGTGACATCGTCGAATCCGACGGCGGGCGGTGCGGCGTTGGGCTCCGGTATCGGACCGACCCGGATCCACACTGTGCTAGGCATTCTCAAGGCCTACACTACTCGGGTGGGTTCTGGTCCTTTCCCTACCGAACTGTTCGACGAGAACGGCGAGTACTTGGCCAAGACTGGTAGCGAGATCGGCGTGACGACAGGACGACGGCGGCGTTGCGGGTGGTTCGACGCCGTGATAGCCCGCTACGCCACCCGGGTCAACGGGATCACCGACTATTTCCTGACCAAGCTTGACGTGCTGTCCAGCTTGGAAACGGTGCCGGTCTGCGTCGGCTATCAGATCGCCGGTGTGCGCACCCACGATATGCCGATAACCCAAAGCGATCTCGCCCGTGCCGAGCCGATCTATGAGGAGCTGCCGGGTTGGTGGGAAGACATCTCCGGAGCGCGGGAATTCGAGGACCTGCCCGCCAAAGCGCGTGACTACGTATTGAGACTGGAAGAACTTGCTGGAGCACAGGTTGCGTGCATAGGTGTCGGTCCGGGACGGGATCAGACCATCGTGCGATGCGATGTATTGAGGAGCCGTCGGTGA

Protein Sequence 

>ML0280c_PurA_protein
MPAVVLIGAQWGDEGKGKVTDLLGGRAQWVVRYQGGNNAGHTVVLPTGENFTLHLIPSGVLTPGVTNVIGNGVVVDPGVLLSELQGLEDRGVDTSQLLISADAHLLMPYHVAIDKVTERYMGNKKIGTTGRGIGPCYQDKIARMGIRVADVLEPGELTHKIEAALEFKNQVLVKIYNRKALDLAQVVETLLEQAQQFRHRITDTRLLLNDALEAGETVLLEGAQGTLLDVDHGTYPYVTSSNPTAGGAALGSGIGPTRIHTVLGILKAYTTRVGSGPFPTELFDENGEYLAKTGSEIGVTTGRRRRCGWFDAVIARYATRVNGITDYFLTKLDVLSSLETVPVCVGYQIAGVRTHDMPITQSDLARAEPIYEELPGWWEDISGAREFEDLPAKARDYVLRLEELAGAQVACIGVGPGRDQTIVRCDVLRSRR

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding PurA with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

2 show intermediate predicted evidence for PPIs

27 show weak predicted evidence for PPIs

View all pooled AlphaFold results for PurA

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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