ispD
mL0321
Probable 4-diphosphocytidyl-2C-methyl-D-erythritol synthase IspD (2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase) (MEP cytidylyltransferase) (MCT)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 410871 – 411596
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL0321_ispD_dna
TGGCTGTGGCAACGGGCACTGTAGTTGCAGTGGTCCCGGCCGCCGGGGCGGGGAAGCGGCTAGCGGCCGGCATTCCGAAGGCATTCTGTGAACTTGACGGGCGTACGCTTGTCGAACGTGCTGTCGTTGGCTTGCTGGAATCTGGCGTTGTTGACCATGTTGTGGTGGCGGTGCCTGCTGATCGCATTGCCCAGACCCAGTGGGTGCTATCCCAACGGCTAGCCAATTCGGCGGGTCAACACGCCACAGTTGTGGCCGGCGGGGCCGACCGCACCAAATCGGTGTGTCAGGCTCTTGCGACCCTTCCCGCCCCGTCAAGGGTGGGCGCACCCGAGTTTATATTGGTGCATGATGCCGCGCGGGCGCTGACACCAGCACGGTTAATCGTGCGGGTGGTTGATGCTTTGCGTGCTGGTCATACCGCGGTCGTTCCAGCGCTGCCACTGTCTGACACCATTAAAGCCGTGGACGCCAACGGAATGGTTCTTGGCACTCCGGCGCGGGTCGGCTTGCGGGCGGTGCAGACCCCGCAGGGGTTTGCTACCGAGCTGCTATGGTGCGCTTATCAGCGTGGCCCCCATCTTGATGCCGTCGATTTCACCGACGATGCTTCCCTTGTCGAACATCTCGGTGGCCAGGTTCAGGTGGTCGCCGGCGATCCACTGGCGTTCAAGATCACCACTCAGTTGGATCTGCTGCTGGCGAAGAAGATTCTGCGCCGGTGAG

Protein Sequence 

>ML0321_IspD_protein
WLWQRAL_LQWSRPPGRGSG_RPAFRRHSVNLTGVRLSNVLSLACWNLALLTMLWWRCLLIALPRPSGCYPNG_PIRRVNTPQLWPAGPTAPNRCVRLLRPFPPRQGWAHPSLYWCMMPRGR_HQHG_SCGWLMLCVLVIPRSFQRCHCLTPLKPWTPTEWFLALRRGSACGRCRPRRGLLPSCYGALISVAPILMPSISPTMLPLSNISVARFRWSPAIHWRSRSPLSWICCWRRRFCAGE

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding IspD with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

1 shows intermediate predicted evidence for PPIs

24 show weak predicted evidence for PPIs

View all pooled AlphaFold results for IspD

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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