cysS1
mL0323
Probable cysteinyl-tRNA synthase 1 CysS1 (Cysteine--tRNA ligase 1) (CysRS 1)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 412124 – 413545
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL0323_cysS1_dna
TGATCGATAGCGGCCATTTGCGGCTCCACGATACGGTAGCTGGTGCTGTGCGCGATTTCGTTCCGCTGCGAGCCGGGCACGTCTCGATCTACCTGTGTGGTGCCACCGTTCAAGGACAGCCGCACATCGGGCACGTCCGCAGCGGGGTAGCCTTCGACATTCTGCGCCGATGGCTCATGGCACGCGGCTATGACGTCGCGTTCATCCGCAACGTCACCGATATCGATGACAAGATTCTTAACAAGGCTGCCGCGGCTGGCCGGCCGTGGTGGGAATGGGCGGCCACCCACGAGCGCGCGTTTACCGCGGCCTATGACGCCTTGGACGTTTTGCCGCCGTCAGCAGAGCCGCGAGCCACCGGGCACATTACCCAGATGATCGAGCTGATCGAGCTGTTGATCGAGACAGGTCACGCCTATACGGGCGGCTCTGATGTTTATTTCGACGTGCTCAGCTACCCGGATTATGGCCAGCTATCTGGGCACAAGATGGACTATATCCACCAAGGCGAAGGTGTGACTACCGGCAAACGTGATCAACGCGACTTTACTTTGTGGAAGGGCGCCAAGTCCGGTGAACCGTCGTGGCCTACGCCGTGGGGCCGTGGCCGTCCAGGCTGGCACCTGGAATGCTCGGCAATGGCTCGTGCTTATCTTGGTTCTGAATTTGACATCCATTGCGGTGGAATGGATTTAGTTTTTCCGCACCACGAAAATGAGATCGCGCAGAGCCGCGCTGTCGGGGATGGCTTCGCCCGTTACTGGCTGCACAACGGCTGGGTAACGATGGGTGGGGAGAAGATGAGTAAGTCGCTGGGTAACGTGTTGTCCATCCCAGCCGTGCTGCAGCGGGTTCGGCCAGCCGAACTGCGTTACTATCTCGGTAGCGCCCACTACCGGTCGATGCTGGAGTTCTCCGAGGCCGCGCTACAGGATGCGGTCAAAGCTTATGTCGGAGTGGAGAATTTCCTGACTAGGGTGCGTACTCGGGTTGGTGCCGTTGGCACCGGCGAACTGACCCCACGGTTCGCTGCAGCACTCGACGACGATCTGGCGGTGCCGATCGCGCTGGCTGAGGTGCACCACGCTCGTGTGGAGGGTAACCGAGCGCTCGACATCGGCGACCACGAAGGTGCGTTGACGAACGCCGGCGCTATTCGAGCGATGATGGGCATCTTAGGTTGCGACCCGCTTGACGAACGTTGGGAATCCCGCGATGAGACGTCGGCGGCGCTAGCGGCTGTCGATGTGCTGGTGGCCGCTGAGCTAGAAAGCCGGCAGATGGCACGCGAGCAGCGTAACTGGGTACTTGCCGATCAGATCCGCGATCGACTCAAGGATGCCGGTATTGAGGTAACTGATACCGTCAACGGGCCGCAGTGGGAACTGTTGGCTGGCGATAAGCAAGTTGATGCCCGGTAAC

Protein Sequence 

>ML0323_CysS1_protein
SIAAICGSTIR_LVLCAISFRCEPGTSRSTCVVPPFKDSRTSGTSAAG_PSTFCADGSWHAAMTSRSSATSPISMTRFLTRLPRLAGRGGNGRPPTSARLPRPMTPWTFCRRQQSREPPGTLPR_SS_SSC_SRQVTPIRAALMFISTCSATRIMASYLGTRWTISTKAKV_LPANVINATLLCGRAPSPVNRRGLRRGAVAVQAGTWNARQWLVLILVLNLTSIAVEWI_FFRTTKMRSRRAALSGMASPVTGCTTAG_RWVGRR_VSRWVTCCPSQPCCSGFGQPNCVTISVAPTTGRCWSSPRPRYRMRSKLMSEWRIS_LGCVLGLVPLAPAN_PHGSLQHSTTIWRCRSRWLRCTTLVWRVTERSTSATTKVR_RTPALFER_WAS_VATRLTNVGNPAMRRRRR_RLSMCWWPLS_KAGRWHASSVTGYLPIRSAIDSRMPVLR_LIPSTGRSGNCWLAISKLMPGN

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding CysS1 with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

2 show intermediate predicted evidence for PPIs

29 show weak predicted evidence for PPIs

View all pooled AlphaFold results for CysS1

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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