guaA
mL0395
Probable GMP synthase [glutamine-hydrolyzing] GuaA (Glutamine amidotransferase) (GMP synthetase)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 491044 – 492633
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL0395_guaA_dna
TGGCTGACTCTGCTGGCCTCGACCAGCCCGAACCCTCGCCCCGCCCCGTGTTGGTGGTCGACTTCGGTGCGCAGTATGCACAGCTTATTGCCCGCCGGGTTCGAGAAGCACGGGTTTTTTCCGAGGTAATTCCGCACACCACCTCGATCGAGGAGATCACCGCCCGTGATCCGCTGGCGATTGTGCTTTCTGGTGGACCGGCCAGTGTCTATACGGAAGGTGCTCCGCAGCTCGATCCAGCGCTGTTTGACCTCGGTTTGCCGGTGTTCGGGATCTGCTACGGGTTTCAGGCCATGGCTCAGGTGCTCGGCGGGACTGTCGCCCGAACCAAGACCAGTGAATACGGCCGGACGGAACTGAAAGTCCTTGGCGGTGATCTGCATTCGGGTCTTCCTGGTGTCCAGCCGGTCTGGATGAGTCACGGTGACGCGGTCACCGCCGCGCCCGATGGATTCGACGTGGCTGCCAGCAGCTCGGGTGCCCCAGTGGCCGCCTTCGAGAACCGGGACCGGCGTCTGGCCGGGGTGCAGTATCACCCGGAGGTGATGCACACCCCGCACGGGCAACAAGTACTCAGCCGGTTCTTGCACGATTTCGCTGGGCTTGACGCGGATTGGACGGCTGCCAACATCGCTGGTGTGCTGGTCGAGCAGGTGCGTGCCCAGATCGGCAACGGCCATGCGATCTGCGGACTGTCTGGAGGTGTGGATTCCGCAGTGGCCGCAGCACTGGTGCAACGCGCCATCGGAGACCGATTGACCTGTATCTTTGTCGATCATGGTCTGCTGCGTGACGGTGAGCGCGGACAGGTGCAGCGTGATTTTGTCGCCGCTACTGGCGCTAAGCTGGTTACCGTCGACGCGGCCGAGACTTTCCTTCAGGCGCTGTCGGGTGTGACCAACCCCGAAGGCAAGCGTAAGATTATCGGACGCCAGTTCATCCGGGCATTTGAAGGTGCAGTACGGGATTTGTTGGGTGACAGCACTTTTGATTCCGGGATCGAGTTCTTGGTTCAGGGCACACTGTATCCGGATGTGGTGGAGTCCGGTGGGGGCAGTGGCACTGCGAACATCAAGAGCCACCACAATGTTGGTGGTCTTCCCGACAACCTAAGGTTCAAGCTCGTTGAGCCGCTGCGGCTGCTATTCAAAGACGAGGTGCGTGCGGTCGGTCGACAGTTGGACCTGCCGGAGGAAATTGTTGCTCGCCAACCATTTCCGGGTCCTGGCCTGGGCATCCGGATCGTTGGTGAGGTGACTGCCGAACGGCTGGACACGCTGCGGCGGGCCGACTCGATAGCGCGTGAGGAGCTGACCACGGCGGGTCTGGACTACCAGATTTGGCAGTGCCCGGTAGTGCTGCTGGCCGACGTACGTTCGGTCGGTGTGCAGGGGGATAATCGCAGTTACGGACACCCGATCGTGCTGCGGCCAGTGTCTAGCGAGGATGCCATGACAGCCGATTGGACCTGGGTTCCTTATGAGGTGTTGGAGTGCATCTCGACGCGTATCACCAACGAGGTTGCTGAGGTTAACCGCGTGGTGTTGGACATCACCAACAAACCGCCCGGCACCATCGAGTGGGAATAGC

Protein Sequence 

>ML0395_GuaA_protein
WLTLLASTSPNPRPAPCWWSTSVRSMHSLLPAGFEKHGFFPR_FRTPPRSRRSPPVIRWRLCFLVDRPVSIRKVLRSSIQRCLTSVCRCSGSATGFRPWLRCSAGLSPEPRPVNTAGRN_KSLAVICIRVFLVSSRSG_VTVTRSPPRPMDSTWLPAARVPQWPPSRTGTGVWPGCSITRR_CTPRTGNKYSAGSCTISLGLTRIGRLPTSLVCWSSRCVPRSATAMRSADCLEVWIPQWPQHWCNAPSETD_PVSLSIMVCCVTVSADRCSVILSPLLALSWLPSTRPRLSFRRCRV_PTPKASVRLSDASSSGHLKVQYGICWVTALLIPGSSSWFRAHCIRMWWSPVGAVALRTSRATTMLVVFPTT_GSSSLSRCGCYSKTRCVRSVDSWTCRRKLLLANHFRVLAWASGSLVR_LPNGWTRCGGPTR_RVRS_PRRVWTTRFGSAR_CCWPTYVRSVCRGIIAVTDTRSCCGQCLARMP_QPIGPGFLMRCWSASRRVSPTRLLRLTAWCWTSPTNRPAPSSGNS

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding GuaA with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

0 show intermediate predicted evidence for PPIs

12 show weak predicted evidence for PPIs

View all pooled AlphaFold results for GuaA

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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