relA
mL0491
PROBABLE GTP PYROPHOSPHOKINASE RELA (ATP:GTP 3'- PYROPHOSPHOTRANSFERASE) (PPGPP SYNTHETASE I) ((P)PPGPP SYNTHETASE) (GTP DIPHOSPHOKINASE)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 595608 – 597971
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL0491_relA_dna
TGGCGGACGACCAAGGTACGGCGCAAGCTTTGCAACCAGTTCAGGTGGTCCCCGGCCCTGCTGTTGAGGCACCGGAGACGCCGGTCGAAACCCTGAAGACTTCTAGCAGTGCGTCTCGTCGGGTCCGGGCTCGGTTGGCCCGTCGGATGACCGCTCAACGCAGCACCATCAGTCCCGTGCTCGAGCCGCTGGTGGCTGTGCATAAAGAGTTTTATCCCAAGGCAAACCTTTCGATAGTGCAGCGAGCCTTTGAAGTCGCCGACCAACGGCACGCCAGTCAACTGCGGCGTTCCGGTGATCCGTACATCACCCATCCGCTGGCCGTTGCCAACATTTTGGCTGAGTTGGGCATGGATATCACTACCCTGGTGGCTGCGCTACTGCACGACACGGTCGAGGACACCGGTTACACGCTCGAGGCACTGTCCGAAGAATTTGGCGACGAGGTAGGCCATCTCGTCGACGGGGTGACCAAGCTGGATCGGGTGGTGCTGGGCAGTGCTGCCGAGGGCGAGACCATCCGCAAGATGATTACCGCAATGGCCCGTGATCCACGGGTGTTGGTTATCAAGGTGGCCGACCGGTTGCATAACATGCGCACCATGCGCTTCCTGCCTCCGGAAAAGCAGGCGCGCAAGGCCCGTGAGACATTGGAAGTCATTGCACCACTAGCGCATAGGCTAGGTATGGCCAGTGTTAAGTGGGAGTTGGAAGACCTGTCTTTCGCGATCTTGCATCCCAAAAAATACGAGGAGATCGTACGGCTGGTAGCGGGCCGTGCACCGTCCCGCGATACCTACCTGGCCAAGGTCCGTGCCGAGATCATAAGTACCCTGGGTGCGTCGAAAATCAAGGCGACGGTGGAGGGCCGGCCCAAGCATTACTGGTCGATTTATCAGAAAATGATCGTCAAGGGGCGAGACTTCGACGATATTCACGACTTGGTCGGCATCCGTATCCTGTGCGACGAGATCCGCGACTGCTATGCCGCTGTCGGCGTGGTGCATTCGTTGTGGCAGCCGATGGCGGGACGGTTTAAAGACTACATTGCTCAGCCGAGGTATGGTGTGTACCAGTCGTTGCACACCACGGTCGTTGGGCCCGAGGGCAAGCCTTTGGAAGTACAGATTCGTACCCGCGATATGCACCGTACCGCCGAATACGGCATAGCAGCGCACTGGCGCTATAAAGAAGCCAAGGGCCGCAACGGTGTTCTGCATCCACATGCAGCCGCAGAGATCGACGATATGGCCTGGATGCGGCAGCTTCTCGACTGGCAACGAGAGGCCGCCGAACCAGGTGAGTTCTTGGAGTCGTTGCGTTACGACCTTGCAGTGCAAGAGATTTTTGTGTTCACTCCTAAAGGGGACGTCATCACGTTGCCGACTGGGTCAACGCCGGTGGACTTTGCCTATGCGGTGCACACCGAGGTCGGGCACCGATGCATTGGTGCCAGAGTCAACGGACGACTGGTGGCGCTGGAGCGCAAGCTGGAAAACGGGGAATTCGTAGAGATTTTCACATCCAAAGCTCCCAATGCCGGGCCTTCGCGGGATTGGCAGCAGTTCGTGGTGTCGCCGCGCGCTAAGACGAAGATCCGTCAATGGTTCGCCAAGGAGCGGCGTGAGGAAGCACTGGAGGCTGGTAAGGATGCGATGGCCCGCGAGGTACGTCGCGGTGGACTTCCTTTGCAGCGCTTGGTGAATGGTGAGTCCATGGCGGCAGTGGCCCGTGAGCTACATTACATTGACGTGTCCGCACTGTATACCGCAATTGGTGAAGGACACGTGTCTGCCCGGCACGTCGTGCAGCGGCTGTTGGCCGAGTTGGGCGGTATCGATCAGGCTGAAGAGGAACTGGCCGAACGGTCCACACCGACGACCATGCTGCGCCGTCAACGCAGCACCGATGATGTCGGGGTTTCGGTCCCCGGCGCCCCAGGTGTGCTGACTAAGCTAGCCAAATGCTGCACGCCGGTACCTGGCGATGCGATCATGGGGTTCGTTACCCGCGGCGGCGGGGTTAGTGTGCACCGCACCGACTGCACCAACACGGCATCGCTGCAGCAGCAGGCCGAGCGCATCATCGAGGTGTTGTGGGCGCCGTCGTCGTCGTCGGTGTTTCTGGTGGCGATTCAGGTGGAGGCGCTCGACCGGCATCGGCTGCTGTTGGACATAACACGCGCGTTAGCCGACGAAAGGGTGGACATTCTATCGGCGTCGGTCACCACGTCGGGTGACCGGGTGGCGATCAGCCGGTTTACCTTCGAGATGGGTGACCCCAAGCACCTCGGACATCTGCTCAATGTGGTCCGCAATGTCGAAGGCGTTTACGATGTCTATCGGGTGATGTCTGCGTCTTGAC

Protein Sequence 

>ML0491_RelA_protein
WRTTKVRRKLCNQFRWSPALLLRHRRRRSKP_RLLAVRLVGSGLGWPVG_PLNAAPSVPCSSRWWLCIKSFIPRQTFR_CSEPLKSPTNGTPVNCGVPVIRTSPIRWPLPTFWLSWAWISLPWWLRYCTTRSRTPVTRSRHCPKNLATR_AISSTG_PSWIGWCWAVLPRARPSAR_LPQWPVIHGCWLSRWPTGCITCAPCASCLRKSRRARPVRHWKSLHH_RIG_VWPVLSGSWKTCLSRSCIPKNTRRSYGW_RAVHRPAIPTWPRSVPRS_VPWVRRKSRRRWRAGPSITGRFIRK_SSRGETSTIFTTWSASVSCATRSATAMPLSAWCIRCGSRWRDGLKTTLLSRGMVCTSRCTPRSLGPRASLWKYRFVPAICTVPPNTA_QRTGAIKKPRAATVFCIHMQPQRSTIWPGCGSFSTGNERPPNQVSSWSRCVTTLQCKRFLCSLLKGTSSRCRLGQRRWTLPMRCTPRSGTDALVPESTDDWWRWSASWKTGNS_RFSHPKLPMPGLRGIGSSSWCRRALRRRSVNGSPRSGVRKHWRLVRMRWPARYVAVDFLCSAW_MVSPWRQWPVSYITLTCPHCIPQLVKDTCLPGTSCSGCWPSWAVSIRLKRNWPNGPHRRPCCAVNAAPMMSGFRSPAPQVC_LS_PNAARRYLAMRSWGSLPAAAGLVCTAPTAPTRHRCSSRPSASSRCCGRRRRRRCFWWRFRWRRSTGIGCCWT_HAR_PTKGWTFYRRRSPRRVTGWRSAGLPSRWVTPSTSDICSMWSAMSKAFTMSIG_CLRLD

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding RelA with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

3 proteins show strong predicted evidence for PPIs

4 show intermediate predicted evidence for PPIs

52 show weak predicted evidence for PPIs

View all pooled AlphaFold results for RelA

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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