hisS
mL0494
Probable histidyl-tRNA synthase HisS (Histidine--tRNA ligase) (HisRS) (Histidine--Translase)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 599741 – 601024
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL0494_hisS_dna
TGACGGAGTCATGCACTGTGTTTTCGTTTTCTGGGCCCAAGGGGATACCGGATTATTTTCCTCCGGACTCGGCGCAATTTGTCGCGGTACGTGATGGTTTGCTCACTGCCGCCCGCAGGGCCGGTTACGGCGATATCGAGTTACCTGTTTTCGAGGACACCGCGTTGTTCGCTCGCGGCGTTGGTGAGTCCACTGACGTGGTAGCCAAGGAGATGTATACGTTTGCTGACCGTGGTGATCGCTCGGTTACGCTGCGTCCCGAGGGCACCGCTGGGGTGGTGCGTGCGGTGATTGAACACGGTCTGGACCGTGGAGCGTTGCCGGTGAAGCTGTGCTACGCGGGCCCGTTTTTCCGATACGAGCGTCCCCAGGCCGGCCGATGTCGCCAACTGCAGCAGGTCGGCGTTGAAGCAATCGGTGTCGACGACCCGGCCCTAGACGCCGAGGTGATCACCATCGCCGACGCTGGCTTCCGCTCCCTGGGTCTGGACGGGTTCCAGTTGGAAATCACTTCGCTGGGCGATGGTACTTGTCGCCCGCAATATCGAAAACTGTTGCAGGAGTTTCTCTTGCAGCTCGACCTTGACGAAGATACCCGCCGACGCGCCGAGCTTAATCCGCTGCGGGTGCTTGATGACAAACGACCCCAGGTGCAAGCGATGACAGCCGCAGCTCCGGTGTTGCTAGACCATTTGTCCGATGGCGCCAAGCAGCACTTCGATACGGTGCTGGCTCACCTGGACGCTCTGCGGGTGCCATATGTCATCAACCCGCGGATGGTGCGAGGGCTGGATTACTACACAAAAACAACCTTCGAGTTCGTCCACCCCGGCTTAGGTGCGCAATCCGGCATCGGCGGCGGTGGACGTTATGATGGTCTAATGCGTCAGCTCGGCGGGCAGGACTTGTCGGGCATCGGATTCGGACTCGGGGTGGACCGGACCTTGCTGGCCCTACATGCCGAAGGCAAGACCGTGGGGGAAACCACACGCTGCGACGTATTCGGTGTGTCGCTGGGTGAAGCTGCTAAACTCAAGGTGGCGATGTTGGCCGGGCAACTGCGTGCTGCCGGCGTCCGCGTCGACCTGATCTACGGGGATCGCGGGATCAGGGGAGCGATGCGTGCGGCGGGCCGTTCCGGTGCTCGCATCGCGTTGATAGTAGATGATTGCGCCATTAAGGCCGACGGTGTCGGTGTGAGGGATCTAGCCACCGGTGAACAGATTTCGGTAGCTGTAGATTCTGTTGTCGCCGAAGTAATTTCGAGAATAGCTCCGAGTTAGC

Protein Sequence 

>ML0494_HisS_protein
RSHALCFRFLGPRGYRIIFLRTRRNLSRYVMVCSLPPAGPVTAISSYLFSRTPRCSLAALVSPLTW_PRRCIRLLTVVIARLRCVPRAPLGWCVR_LNTVWTVERCR_SCATRARFSDTSVPRPADVANCSRSALKQSVSTTRP_TPR_SPSPTLASAPWVWTGSSWKSLRWAMVLVARNIENCCRSFSCSSTLTKIPADAPSLIRCGCLMTNDPRCKR_QPQLRCC_TICPMAPSSTSIRCWLTWTLCGCHMSSTRGWCEGWITTQKQPSSSSTPA_VRNPASAAVDVMMV_CVSSAGRTCRASDSDSGWTGPCWPYMPKARPWGKPHAATYSVCRWVKLLNSRWRCWPGNCVLPASAST_STGIAGSGERCVRRAVPVLASR___MIAPLRPTVSV_GI_PPVNRFR_L_ILLSPK_FRE_LRVS

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding HisS with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

0 proteins show strong predicted evidence for PPIs

0 show intermediate predicted evidence for PPIs

2 show weak predicted evidence for PPIs

View all pooled AlphaFold results for HisS

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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