alaS
mL0512
Probable alanyl-tRNA synthetase AlaS (Alanine--tRNA ligase) (Alanine translase) AlaRS)
M. leprae · TN
[TnSeq DB] [SeqHub]
TN Coordinates: 622160 – 624886
Vulnerability Index (VI):
Click the tabs above to view different types of data for this gene. The Vulnerability tab shows CRISPRi fitness data.
DNA and Protein Sequence help

DNA Sequence 

>mL0512_alaS_dna
TGCAAACACACGAGATCAGGAAGCGGTTCCTTGATCATTTTGTGAAGGCGGGCCACACCGAGGTGCCTAGCGCGTCAGTAATCCTCGATGACCCCAACCTGTTGTTCGTCAACGCTGGCATGGTCCAGTTCGTGCCGTTCTTTCTGGGGCAGTGTACGCCGCCGTACGCGACGGCCACCAGCATCCAGAAATGCATCCGCACTCCTGACATCGACGATGTGGGTATCACCACCCGGCACAACACCTTTTTCCAGATGGCGGGCAATTTCTCGTTCGGGGACTACTTCAAGCGCGGGGCTATCGAACTGGCCTGGGCGTTGCTGACTAACAGCTTTGCCGACGGGGGCTACGGGCTGGACCCAGAGAGACTCTGGGCCACGGTGTATCTCGATGACGACGAGGCTGCAGGCCTATGGCAGGAGATCGCCGGACTGCCACCTGAGCGAATCCAGCGTCGTGGTATGGCCGACAACTACTGGTCGATGGGCATCCCTGGGCCATGCGGGCCGTCGTCGGAGATTTACTACGACCGCGGGCCCGAGTTCGGCCCCGAAGGCGGTCCCATCGTCAATGAGGACCGCTACCTCGAGGTCTGGAACCTCGTGTTCATGCAAAACGAACGCGGTGAGGGGACTACCAAGGAGGACTACGAGATCCGCGGACCGCTGCCACGCAAGAACATCGACACTGGCATGGGTGTTGAGCGGATTGCGTTGGTTCTGCAGGGCGTGCACAACGTCTACGAGATCGATCTGCTGCGGCCGGTGATTGACCTAGTGGCGACCCGCGCACCGCGCCCGTATGACCCCGAAAATGAAGACACCAATCACGCCGACAACGTCCGCTACCGCATTATCGCAGACCACAGCCGCACCGCCGCCATCCTTATCGGCGACGGTGTAAGTCCCGTCAACGACGGTCGTGGTTATGTGTTGCGTCGTTTGCTACGCCGGATAATCCGTTCGGCCAAGCTGTTGGGCATCGATAGCCCGATCGTGGGCGACCTGATGGCTACCGTGTGCAATGCGATGGGGCGAGCTTATCCAGGGCTGGTCACCGACTTTGACCGGATCAACCGCATTGCCGTCGCTGAAGAGACGGCATTCAACCGCACCCTGACTTCTGGCTCGAAGCTGTTTGACGACGTCGTCGGCGCCACCGTAGCGTCGGGCTCCACCGTGGTCGCCGGTTTGGACGCCTTTACCCTGCATGATACCTACGGTTTCCCAATCGAGCTCACCTTGGAGATGGCGGCCGAAGCCGGTCTGACCGTGGATGAGAAGGGATTTCACGAGTTGATGCTGCAACAGCGTCAGCGCGCCAAGGTCGATGCCGCCGCCCGCAAGCAGGCACACGTCGACCTGACTGCGTACCGTGAGCTGGTCGACGCCGGTCCGACTGAGTTTACTGGCTTCGACGAATTGACTACCGAGGCAAGAATTCTCGGCATCTTTGTCGAAGGCAAGCGGGTCCCGGTAGTCGCGCACGCCGTTCGAGGCCAAGCTGGCATCACCAATCGGGTAGAGCTGGTGTTGGATCGCACTCCGCTTTATGCTGAGTCGGGAGGCCAGATTGCTGACGCCGGCACCATCAGCGGAATTGGTGCCGGAGCCAGCTCCCGGGCGGCGGTCACCGACGTGCAAAAGATCGCTAAAACTCTTCATGTCCACCGGGTTAACTTAGAATCCGGGGAATTCGTCGAGGGTGATACCGTTGTTGCGGTAGTCGACCCGGGTTGGCGCAGGGGCGCCGCGCAAGGGCATTCGGGTACCCACATCGTGCACGCCGCGCTGCGCCAAGTGCTGGGGCCCAACGCCGTTCAGGCTGGCTCGCTGAACCGGCCGGGCTACTTGCGTTTTGACTTCAACTGGCAGGGTTCGTTGACTGGTGAGCAGCGTACCCAAATCGAAGAAGTCACCAACGAAGCTGTGCAAGCCGACTTCGAGGTACACACCTTCACCGAAAAGCTCGACACAGCTAAAGCGATGGGCGCCATAGCCCTGTTTGGTGAGGCCTATCCCGACGAGGTGCGGGTGGTGGAGATGGGCGGACCGTTCTCGCTGGAGTTGTGCGGCGGCACGCATGTGCACAACACGGCGCAGATTGGCCCGGTCACGATCCTGGGTGAATCGTCGATCGGCTCCGGGGTGCGCCGGGTGGAAGCATACGTCGGACTGGATTCGTTTCGCCACCTGGCCAAAGAGCGTGCGCTGATGGCAGGGCTGGCATCATCACTGCAGGTGCCTTCCGAGGAGGTACACGCTCGGGTAGCCACGCTGGTGGAGCGGCTGAAGGCCGCCGAGAAGGAACTCGAGCGCGCTCGGCAGGCAAACGTCCAGGCGGCGGCGACCAAAGCCGCGGCGGGTGCTGAGTGGATCGGTAATGTGCGGGTTGTGGTGCAACGGATGTCCGGCCCGATAGCACCAGACGACTTACGCTTCCTGGTCGGCGATATCCGCGGCAAACTGGGCAGTGATCCGGCGGTGGTCGCGCTGATCGCGGTGACTTCGGATGGGCCGACCGCAACTGTGCCGTACGCGGTCGCTGCCAATCCCGCCGCCCAGGATCTGGGAATTCGCGCCAACGATCTGGTGGAACAGCTCGCTATGGTCGTAGACGGGCGCGGCGGCGGTAAGGCCGACCTGGCGCAAGGTTCAGGAAAGGACCCGACTGGCATCGACGCTGCGCTTGACACGGTACGTGCACAGATAGCGCAGGTCGGTTGAG

Protein Sequence 

>ML0512_AlaS_protein
CKHTRSGSGSLIIL_RRATPRCLARQ_SSMTPTCCSSTLAWSSSCRSFWGSVRRRTRRPPASRNASALLTSTMWVSPPGTTPFSRWRAISRSGTTSSAGLSNWPGRC_LTALPTGATGWTQRDSGPRCISMTTRLQAYGRRSPDCHLSESSVVVWPTTTGRWASLGHAGRRRRFTTTAGPSSAPKAVPSSMRTATSRSGTSCSCKTNAVRGLPRRTTRSADRCHARTSTLAWVLSGLRWFCRACTTSTRSICCGR_LT_WRPAHRARMTPKMKTPITPTTSATALSQTTAAPPPSLSATV_VPSTTVVVMCCVVCYAG_SVRPSCWASIARSWAT_WLPCAMRWGELIQGWSPTLTGSTALPSLKRRHSTAP_LLARSCLTTSSAPP_RRAPPWSPVWTPLPCMIPTVSQSSSPWRWRPKPV_PWMRRDFTS_CCNSVSAPRSMPPPASRHTST_LRTVSWSTPVRLSLLASTN_LPRQEFSASLSKASGSR_SRTPFEAKLASPIG_SWCWIALRFMLSREARLLTPAPSAELVPEPAPGRRSPTCKRSLKLFMSTGLT_NPGNSSRVIPLLR_STRVGAGAPRKGIRVPTSCTPRCAKCWGPTPFRLAR_TGRATCVLTSTGRVR_LVSSVPKSKKSPTKLCKPTSRYTPSPKSSTQLKRWAP_PCLVRPIPTRCGWWRWADRSRWSCAAARMCTTRRRLARSRSWVNRRSAPGCAGWKHTSDWIRFATWPKSVR_WQGWHHHCRCLPRRYTLG_PRWWSG_RPPRRNSSALGRQTSRRRRPKPRRVLSGSVMCGLWCNGCPAR_HQTTYASWSAISAANWAVIRRWSR_SR_LRMGRPQLCRTRSLPIPPPRIWEFAPTIWWNSSLWS_TGAAAVRPTWRKVQERTRLASTLRLTRYVHR_RRSVE

No essentiality data available for this gene.

AlphaFold Protein Interactions

Protein–protein interactions (PPIs) were predicted by co-folding AlaS with every other protein in the M. leprae proteome using a pooled-AlphaFold3 based approach (Horia et al.). The size-corrected interface predicted template modeling (sciPTM) score indicates confidence in the predicted interaction: weak evidence (sciPTM > 0.05), intermediate evidence (sciPTM > 0.2), or strong evidence (sciPTM > 0.4).

1 protein shows strong predicted evidence for PPIs

3 show intermediate predicted evidence for PPIs

25 show weak predicted evidence for PPIs

View all pooled AlphaFold results for AlaS

Use of these data is subject to the AlphaFold Server Output Terms of Use.

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